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New drug combo tested to fight advanced cancers

NCT ID NCT04381650

Completed Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

Summary

This study tested a new drug, TAK-981, combined with an existing immunotherapy (pembrolizumab) for people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to find a safe dose and see if the combination could help shrink tumors. About 161 people with specific cancers, including lung, cervical, and melanoma, received the treatment in 21-day cycles for up to two years.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08901, United States

  • Centrum Onkologii im. Prof. Franciszka Lukaszczyka w Bydgoszczy

    Bydgoszcz, 85-796, Poland

  • Centrum Terapii Wspolczesnej

    Lodz, Łódź Voivodeship, 90-242, Poland

  • Cetus Hospital Dia Oncologia

    Belo Horizonte, 30110-140, Brazil

  • Clinical Hospital Centre Osijek

    Osijek, 31000, Croatia

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Fundacao Pio XII Hospital de Cancer de Barretos

    Barretos, São Paulo, 14784-370, Brazil

  • General Hospital Pula

    Pula, 52100, Croatia

  • Georgia Cancer Center at Augusta University

    Augusta, Georgia, 30912, United States

  • HonorHealth

    Scottsdale, Arizona, 85258, United States

  • Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS)

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Hospital de Base Da Faculdade de Medicina de Sao Jose Do Rio Preto

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Hospital de Clinicas de Porto Alegre (HCPA) - PPDS

    Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

  • Hospital of Lithuanian University of Health Sciences Kaunas Clinics

    Kaunas, Kaunas County, LT-50161, Lithuania

  • Hospital of Lithuanian University of Health Sciences Kauno klinikos

    Kaunas, Kaunas County, LT-50161, Lithuania

  • INCA Instituto Nacional de Cancer

    Rio de Janeiro, 20230-230, Brazil

  • Instituto Do Cancer Do Estado de Sao Paulo Octavio Frias de Oliveira

    Rio de Janeiro, 20941-150, Brazil

  • Instituto de Oncologia Do Parana

    Curitiba, Paraná, 80530-010, Brazil

  • Instytut Medyczny Santa Familia Sp. z o. o.

    Lodz, 90-302, Poland

  • Kantonsspital Muensterlingen

    Münsterlingen, Thurgau (de), 8596, Switzerland

  • Kantonsspital Winterthur

    Winterthur, Zurich (de), 8400, Switzerland

  • Klinicki bolnicki centar Zagreb

    Zagreb, City of Zagreb, 10000, Croatia

  • Med-Polonia Sp. z o.o.

    Poznan, 60-569, Poland

  • Montefiore Einstein Cancer Center - BRANY - PPDS

    The Bronx, New York, 10461, United States

  • Morristown Medical Center

    Morristown, New Jersey, 07960, United States

  • National Cancer Center East

    Kashiwa-Shi, Chiba, 277-0882, Japan

  • National Cancer Center Hospital

    Chuo-Ku, Tokyo, 104-0045, Japan

  • National Cancer Institute

    Vilnius, Vilnius County, LT-08660, Lithuania

  • ONCOSITE Centro de Pesquisa Clinica Em Oncologia

    Ijuí, Rio Grande do Sul, 98700-000, Brazil

  • Pauls Stradins Clinical University Hospital

    Riga, LV-1002, Latvia

  • Providence Cancer Institute, Franz Clinic

    Portland, Oregon, 97213, United States

  • Riga East Clinical University Hospital Latvian Oncology Center

    Riga, LV-1079, Latvia

  • START South Texas Accelerated Research Therapeutics

    San Antonio, Texas, 78229, United States

  • Specjalistyczna Praktyka Lekarska Slawomir Mandziuk

    Lublin, 20-362, Poland

  • Stanford Cancer Institute (SCI)

    Stanford, California, 94305, United States

  • Sun Yat-Sen University Cancer Center

    Guangzhou, Guangdong, 510060, China

  • The Cancer Institute Hospital of Japanese Foundation For Cancer Research

    Chuo-Ku, Tokyo, 104-0045, Japan

  • The Center for Cancer and Blood Disorders - PPDS

    Bethesda, Maryland, 20817, United States

  • The First Affiliated Hospital, Zhejiang University School of Medicine - PPDS

    Hangzhou, Zhejiang, 310003, China

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15213, United States

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei, China

  • Universitaetsspital Bern - Inselspital

    Bern, 3010, Switzerland

  • University Hospital Centre Split

    Split, 21000, Croatia

  • University of California Irvine Medical Center

    Orange, California, 92868, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27514, United States

  • University of Oklahoma Peggy and Charles Stephenson Cancer Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • University of Virginia Health System

    Charlottesville, Virginia, 22908, United States

  • Uniwersyteckie Centrum Kliniczne-Ul. Smoluchowskiego 17

    Gdansk, Pomeranian Voivodeship, 80-214, Poland

  • Virginia Cancer Specialists (Fairfax) - USOR

    Fairfax, Virginia, 22031, United States

  • Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie

    Olsztyn, 10-357, Poland

  • Yale Cancer Center

    New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED OR METASTATIC SOLID TUMORS