New drug may beat standard therapy in aggressive leukemia
NCT ID NCT03589326
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial tests whether ponatinib (Iclusig) works better than imatinib (Gleevec) for adults newly diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Both drugs are taken as pills alongside reduced-intensity chemotherapy for up to 20 months, then continued alone. The main goal is to see if more patients achieve a deep remission (no detectable cancer cells) with ponatinib. About 245 participants are enrolled across multiple centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ponatinib (Iclusig) or Imatinib (Gleevec) tablets, plus reduced-intensity chemotherapy
What this could lead to
If ponatinib works better, it could become a new standard first-line treatment for Ph+ ALL, helping more patients achieve deep remission without needing lifelong medication.
What could go wrong
This is a phase 3 trial, but results are not yet final. Ponatinib may not prove superior to imatinib, and it carries risks like blood clots or heart problems. The study only includes newly diagnosed patients, so findings may not apply to others.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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855 West 12th Avenue
Vancouver, British Columbia, V5Z 1M9, Canada
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Aiiku Hospital
Sapporo, Hokkaido, 064-0804, Japan
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Almazov Federal North-West Medical Research Centre of Department of Health of Russian Federation
Saint Petersburg, 197341, Russia
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Ankara Universitesi Tp Fakultesi
Ankara, 06590, Turkey (Türkiye)
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Arcispedale Santa Maria Nuova
Reggio Emilia, Reggio Nella Emilia, 42123, Italy
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Augusta University Georgia Cancer Center
Augusta, Georgia, 30912, United States
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Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello
Palermo, 90146, Italy
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Azienda Ospedaliera San Gerardo di Monza
Monza, Monza E Brianza, 20090, Italy
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Azienda Ospedaliera Vito Fazzi
Lecce, 73100, Italy
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Azienda Ospedaliero Universitaria di Bologna Policlinico Sant'Orsola-Malpighi
Bologna, 40138, Italy
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Azienda Ospedaliero-Universitaria di Modena Policlinico
Modena, 41124, Italy
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Azienda Policlinico San Martino
Genoa, Liguria, 16132, Italy
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Azienda USL della Romagna
Ravenna, 48121, Italy
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Box Hill Hospital
Box Hill, Victoria, 3128, Australia
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Center Hospitalier Universitaire d'Angers
Angers, Pays de la Loire Region, 49933, France
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Centre Hospitalier Lyon Sud
Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France
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Centre Hospitalier de Versailles Hopital Andre Mignot
Le Chesnay, Île-de-France Region, 78157, France
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Centro di Ematologia Policlinico Umberto I Universita Sapienza di Roma
Roma, 00161, Italy
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Chiba Aoba Municipal Hospital
Chiba, Chiba, 260-0852, Japan
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China Medical University Hospital
Taichung, Taichung CITY, 40447, Taiwan
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Chonbuk National University Hospital
Jeonju, Jeollabuk-do, 54907, South Korea
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City Clinical Hospital named after Vikentiy Vikentyevich Veresaev
Moscow, Moscow CITY, 127644, Russia
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City of Hope - Duarte
Duarte, California, 91010, United States
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Evaggelismos General Hospital
Athens, Ipsiladou 45-47, 10676, Greece
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Fondazione Policlinico Universitario Agostino Gemelli
Roma, 00168, Italy
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Fukushima Medical University Hospital
Fukushima, Fukushima, 960-1295, Japan
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Fundacao Antonio Prudente - A.C.Camargo Cancer Center
São Paulo, 01509-900, Brazil
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Fundacao Doutor Amaral Carvalho
Jaú, São Paulo, 17210-120, Brazil
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General University Hospital of Patras Panagia I Voithia
Pátrai, Rio, 26504, Greece
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HEMORIO Instituto Estadual de Hematologia Arthur Siqueira de Cavalcanti
Rio de Janeiro, 20211-030, Brazil
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Hanusch Krankenhaus Wiener Gebietskrankenkasse
Vienna, State of Vienna, 1140, Austria
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Helsingin ja Uudenmaan sairaanhoitopiiri
Helsinki, 00029 HUS, Finland
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Hemocentro Campinas Unicamp
Campinas, São Paulo, 130383-878, Brazil
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Henan Cancer Hospital
Zhengzhou, Henan, 450008, China
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Hopital Charles-LeMoyne
Greenfield Park, Quebec, J4V 2H1, Canada
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Hopital Maisonneuve-Rosemont
Montreal, Quebec, H1T 2M4, Canada
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Hospital Erasto Gaertner
Curitiba, Paraná, 81520-060, Brazil
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Hospital Privado Centro Medico de Cordoba
Córdoba, X5014KEH, Argentina
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Hospital Sao Rafael-Monte Tabor
Salvador, Estado de Bahia, 41253-190, Brazil
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitari i Politecnic La Fe de Valencia
Valencia, 46026, Spain
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Hospital Universitario Dr. Jose Eleuterio Gonzalez
Monterrey, Nuevo León, 64460, Mexico
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Hospital Universitario de Salamanca
Salamanca, 37007, Spain
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Hospital da Cidade
Passo Fundo, Rio Grande do Sul, 99010-260, Brazil
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Hospital das Clinicas da Faculdade de Medicina da Riberao Preto da Universidade de Sao Paulo
Ribeirão Preto, São Paulo, 14048-900, Brazil
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Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035-003, Brazil
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Hualien Tzu Chi Hospital
Hualien City, Hualien, 970, Taiwan
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Indiana Blood & Marrow Transplantation
Indianapolis, Indiana, 46237, United States
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Indiana University
Indianapolis, Indiana, 46202, United States
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Inje University Haeundae Paik Hospital
Busan, 48108, South Korea
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Institut Catala d'Oncologia Badalona - Hospital Germans Trias i Pujol
Badalona, Catalonia, 08916, Spain
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Institut Universitaire du Cancer de Toulouse Oncopole
Toulouse, Midi-pyrenees, 31059, France
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Institute of Hematology & Blood Diseases Hospital of CAMS & PUMC
Tianjin, 300041, China
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Instituto do Cancer do Estado de Sao Paulo
São Paulo, 01246-000, Brazil
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Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
Meldola, Forli-cesena, 47014, Italy
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Istituto Scientifico Universitario San Raffaele
Milan, 20132, Italy
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Kyungpook National University Hospital
Daegu, Gyeongsangbuk-do, 41944, South Korea
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Methodist Hospital
San Antonio, Texas, 78229, United States
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Monash Medical Centre
Clayton, Victoria, 3168, Australia
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Monter Cancer Center
New Hyde Park, New York, 11042, United States
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National Cancer Center Hospital East
Kashiwa, Chiba, 277-8577, Japan
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National Cheng Kung University Hospital
Tainan, Tainan CITY, 70403, Taiwan
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National Research Center for Hematology, Dept. of Hematology/Oncology and BMT
Moscow, 125167, Russia
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Okayama University Hospital
Okayama, Okayama-ken, 700-8558, Japan
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Ordensklinikum Linz Elisabethinen
Linz, Upper Austria, 4020, Austria
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Ospedale dell'Angelo
Mestre, Venezia, 30174, Italy
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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Royal North Shore Hospital
Saint Leonards, New South Wales, 2065, Australia
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Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych z Warminsko-Mazurs
Olsztyn, Warmian-Masurian Voivodeship, 10-228, Poland
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Sanatorio Allende
Córdoba, X5000JHQ, Argentina
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Stony Brook University Medical Center
Stony Brook, New York, 11794, United States
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Sverdlovsk Regional Clinical Hospital #1
Yekaterinburg, Sverdlovsk Oblast, 620102, Russia
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Szpital Uniwersytecki w Krakowie
Krakow, Lesser Poland Voivodeship, 31-501, Poland
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The Catholic University of Korea St. Vincent's Hospital
Suwon, Gyeonggi-do, 16247, South Korea
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The First Affiliated Hospital of Soochow University/Suzhou First People's Hospital
Suzhou, Jiangsu, 215006, China
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The First Affiliated Hospital, Zhejiang University
Hangzhou, Zhejiang, 310003, China
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The First Hospital of Jilin University
Changchun, Jilin, 130021, China
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The Ottawa Hospital
Ottawa, Ontario, K1H 8L6, Canada
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The University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Tokai University Hospital
Isehara, Kanagawa, 259-1193, Japan
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Universitaetsklinik Fuer Innere Medizin I
Vienna, 1090, Austria
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University General Hospital of Athens Attikon
Chaïdári, Attica, 12462, Greece
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University Multiprofile Hospital for Active Treatment Saint Ivan Rilski
Sofia, Sofia, 1431, Bulgaria
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
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University of California Los Angeles
Los Angeles, California, 90095, United States
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University of Kansas Medical Center Research Institute
Kansas City, Kansas, 66160, United States
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University of Maryland Medical Center
Baltimore, Maryland, 21201, United States
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Uniwersytecki Szpital Kliniczny we Wroclawiu
Wroclaw, Lower Silesian Voivodeship, 50-367, Poland
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Uniwersyteckie Centrum Kliniczne
Gdansk, Pomeranian Voivodeship, 80-214, Poland
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Yeungnam University Hospital
Daegu, 42415, South Korea