New hope for kids with pouchitis: drug trial targets inflammation
NCT ID NCT06443502
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether vedolizumab (Entyvio) can improve symptoms and reduce inflammation in children with chronic pouchitis, a condition where an internal pouch becomes inflamed after bowel surgery. About 30 children will receive up to 12 infusions over 82 weeks. The main goal is to see if symptoms and pouch inflammation improve by week 14.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
vedolizumab (Entyvio)
What this could lead to
If successful, this could provide a new treatment option for children with chronic pouchitis, helping control inflammation and improve quality of life.
What could go wrong
This is a small, single-arm study with no placebo group, so results may be less reliable. Side effects of vedolizumab include infusion reactions and increased infection risk.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AOU dell'Universita degli Studi della Campania Luigi Vanvitelli
RECRUITINGNaples, 80138, Italy
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Azienda Ospedaliero Universitaria, Policlinico Gaetano Martino
RECRUITINGMessina, 98124, Italy
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Azienda Ospedaliero-Universitaria Policlinico Umberto I
RECRUITINGRome, 00161, Italy
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital Zagreb
RECRUITINGZagreb, 10000, Croatia
Contact
Contact Email: •••••@•••••
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Fakultni nemocnice v Motole, Pediatricka klinika 2
RECRUITINGPrague, 150 06, Czechia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Sant Joan de Deu
RECRUITINGEsplugues de Llobregat, Barcelona, 8950, Spain
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitari I Politecnic La Fe de Valencia
RECRUITINGValencia, 46026, Spain
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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IRCCS Materno Infantile Burlo Garofolo
RECRUITINGTrieste, 34137, Italy
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Instytut Pomnik-/Centrum Zdrowia dziecka
RECRUITINGWarsaw, 04-730, Poland
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Istituto G Gaslini Ospedale Pediatrico IRCCS
RECRUITINGGenova, 16147, Italy
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Schneider Children's Medical Center of Israel
RECRUITINGPetah Tikva, 4920235, Israel
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shaare Zedek Medical Center
RECRUITINGJerusalem, 9103102, Israel
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sotiria Thoracic Diseases Hospital, Dpt. of Gastroenterology, Building Z
RECRUITINGAthens, Attica, 115 27, Greece
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UZ Leuven
RECRUITINGLeuven, Vlaams-Brabant, 3000, Belgium
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••