OVERWEIGHT OR OBESITY

This study tests whether a dietary supplement called Satisens®, made from lemon verbena, hibiscus, saffron, and carob extract, can help reduce emotional eating and cravings for sweets in healthy adults who are overweight or obese. Participants take two capsules daily for a set pe…

This study tested a new drug called MET097, given as a weekly injection, to help adults with obesity or overweight lose weight. 239 participants received either MET097 or a placebo for 28 weeks. The main goal was to see how much weight people lost compared to those on placebo. Re…

This Phase 2 study tested an injectable drug called HRS9531 in 61 overweight or obese adults to see if it helps with weight loss over 36 weeks. Participants received either the drug or a placebo, and researchers measured changes in body weight. The goal is to find a new treatment…

This study looked at whether three different low-calorie diets could improve blood sugar and body composition in 120 shift workers who are overweight and have prediabetes or type 2 diabetes. Each diet had a different amount and timing of protein. The goal was to see which approac…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This completed study gave 580 Native American adults and children in Osage Nation weekly boxes of fresh fruits and vegetables along with healthy recipes and cooking classes. The goal was to see if this program could improve diet, lower blood pressure, and reduce health risks like…

This early-stage trial tested a new drug called AMG 133 (Maridebart cafraglutide) in 57 adults with overweight or obesity. The goal was to see how the drug affects stomach emptying, using acetaminophen as a marker. Participants received either the drug or a placebo, and researche…

This early-stage trial tested the safety and tolerability of ZT002, an injectable drug for weight loss, in 28 adults with overweight or obesity. Participants received multiple doses of ZT002 or a placebo to see how the body processes the drug and if any side effects occur. The st…

This study tested an experimental injection called ZT002 in 303 adults who were overweight or obese. Participants received either the drug or a placebo for 24 weeks. The main goal was to see how much weight they lost and whether they achieved 5%, 10%, or 15% weight loss. The tria…

This early-stage trial tested a new drug called CT-996 in 94 overweight or obese adults, including some with type 2 diabetes. The main goal was to check safety and how the body processes the drug. Researchers gave single or multiple doses and monitored side effects. This is a fir…

This study tested whether retatrutide, a medication being studied for weight loss, can help preserve kidney function in 146 adults who are overweight or obese and have chronic kidney disease (with or without type 2 diabetes). Participants received the drug or a placebo for about …

This study tested whether a probiotic called Akkermansia muciniphila Akk11 can help overweight or obese adults improve their metabolism and gut health. 110 participants took either the probiotic or a placebo daily. Researchers measured changes in appetite-related hormones and oth…

This study tested an experimental oral medication called TERN-601 in 167 adults with overweight or obesity. The goal was to see if it helps with weight loss over 12 weeks compared to a placebo. Participants did not have diabetes and had a stable weight before starting. The study …

This study looked at whether getting more sleep or keeping a regular bedtime could improve how the body handles sugar and insulin in overweight adults who usually sleep less than 7 hours a night. Eighteen African American men and women aged 21-50 were asked to either extend their…

This study tested a program called eMOMS that combines breastfeeding support with a diabetes prevention plan for pregnant women who were overweight or obese before pregnancy. The program was delivered by a health coach through a mobile app. Researchers wanted to see if it could h…

This early-stage study tested a new injection called HRS-4729 in 102 healthy adults who were overweight or obese. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effec…

This study tested two online treatments for teenagers who have bulimia nervosa (binge eating and purging) and are overweight. The goal was to see if these therapies are practical and helpful for reducing binge eating and purging. Twenty-five teens participated, and the study meas…

This pilot study tested an online guided self-help program for teens aged 12–17 who binge eat and have a higher weight. Eight teens completed weekly online sessions over four months. The main goal was to see if the program was practical and acceptable, not to measure effectivenes…

This study tested whether a special cooling pillow pad called Moona can help African American adults with overweight or obesity sleep better. 18 participants used either the active cooling pad or an inactive version for 22 days. Researchers measured sleep quality, timing, and blo…

This study tested whether a 6-month high-intensity functional training program is feasible and helpful for overweight or obese adults with long-term mobility disabilities. Twenty-five participants did exercise sessions three times a week. The goal was to see if the program could …

This study tested a new computer algorithm that uses data from wearable sensors and food diaries to predict a person's real-time risk of developing prediabetes. 77 overweight or obese adults wore glucose monitors and fitness trackers for 4 months. The goal was to collect data to …