OVERWEIGHT OR OBESITY

This study tested whether an investigational drug called retatrutide could improve kidney function in people who are overweight or obese and have chronic kidney disease, with or without type 2 diabetes. The 31-week trial involved 146 participants and compared the drug's effects t…

This early-stage study tested how an experimental drug called AMG 133 affects how quickly the stomach empties in people with overweight or obesity. Researchers gave 57 participants either the drug or a placebo and measured its effects using a common painkiller (acetaminophen) as …

This was an early-stage study to check the safety and drug levels of a new injection called ZT002 in people with overweight or obesity. Twenty-eight adults received either the drug or a placebo (dummy injection) in increasing doses. The main goal was to see how well the body hand…

This study tested whether a new oral medication called TERN-601 helps adults with overweight or obesity lose weight. Researchers compared the drug to a placebo (inactive pill) in 167 participants over 12 weeks. The main goal was to see how much body weight changed and to check th…

This study tested whether a new injectable medication called ZT002 helps people with overweight or obesity lose weight. Over 300 adults received either the medication or a placebo (dummy injection) for 24 weeks. The main goal was to see how much their body weight changed from the…

This was the first study in humans to test the safety and basic effects of an experimental drug called CT-996. It involved 94 overweight or obese adults, some with type 2 diabetes, to see how their bodies handled the drug and if it caused any side effects. The main goal was to de…

This study tested whether a specific probiotic bacteria, taken as a food supplement, could help regulate body metabolism and improve gut health in overweight or obese adults. It involved 110 participants who were randomly assigned to receive either the probiotic or a placebo pill…

This study tested whether providing Native American families with weekly boxes of fresh fruits and vegetables, along with cooking education, could improve their health. About 580 participants from the Osage Nation received the produce for 16 weeks while researchers measured chang…

This study tested whether a special phone app could help new mothers. The app provided coaching to support breastfeeding and healthy habits, aiming to help moms lose pregnancy weight and breastfeed longer. Researchers wanted to see if using the app was practical and if it helped …

This small pilot study explored whether improving sleep could lower the risk of developing diabetes and obesity. Researchers worked with 18 overweight Black adults who were short sleepers, having them either extend their nightly sleep by about 2 hours or stick to a very regular s…

This Yale University study tested whether online cognitive behavioral therapy is a practical and acceptable treatment for teenagers with bulimia nervosa who have higher weight. Twenty-five teens participated in 4 months of weekly video therapy sessions aimed at reducing binge eat…

This small, completed pilot study tested whether a cooling pillow pad could improve sleep quality and related metabolic health in African American adults with overweight or obesity. Researchers wanted to see if this non-drug approach could help people fall asleep faster, sleep be…

This small pilot study tested whether an online guided self-help program is practical and acceptable for teenagers struggling with binge eating and higher weight. Eight teens aged 12-17 tried a four-month program with weekly online sessions. The main goal was to see if teens woul…