Could a Muscle-Building drug boost weight loss? new trial tests bimagrumab with semaglutide

NCT ID NCT05616013

Completed Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This phase 2 study tests whether bimagrumab, a drug that blocks a protein involved in muscle loss, can help overweight or obese adults lose more weight when used alone or alongside semaglutide (the drug in Wegovy and Ozempic). The trial includes about 500 men and women aged 18 to 80. Researchers will measure changes in body weight and waist size over 48 weeks to see if the combination is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bimagrumab and semaglutide
What this could lead to: If successful, this could lead to a new treatment option that helps people lose more weight than current medications alone, potentially improving health outcomes for obesity.
What could go wrong: This is an early-phase trial, so the results may not confirm effectiveness or safety. Side effects from the drugs are possible, and the combination may not work better than existing treatments.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESE OBESITY OVERWEIGHT OR OBESITY

Contacts and locations

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Locations

Altus Research

Lake Worth, Florida, 33461, United States
Austin Health

Heidelberg Heights, Victoria, 3081, Australia
Clinical Neuroscience Solutions Inc

Jacksonville, Florida, 32256, United States
Cullman Clinical Trials

Cullman, Alabama, 35055, United States
Emeritus Research

Camberwell, 3124, Australia
Gold Coast University Hospital

Southport, Queensland, 4215, Australia
Indago Research & Health Center, Inc

Hialeah, Florida, 33012, United States
Lakeland Clinical Trials Waikato

Hamilton, 3200, New Zealand
Middlemore Hospital

Auckland, 2025, New Zealand
Monroe Biomedical Research

Monroe, North Carolina, 28112, United States
Mt. Olympus Medical Research

Sugar Land, Texas, 77479, United States
New Zealand Clinical Research Auckland

Auckland, 1010, New Zealand
New Zealand Clinical Research Christchurch

Christchurch, 8011, New Zealand
Northern Beaches Clinical Research

Brookvale, New South Wales, 2100, Australia
Optimal Clinical Trials

Auckland, 1010, New Zealand
P3 Research

Newtown, Wellington Region, 6242, New Zealand
Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States
Pinnacle Research Group, LLC

Anniston, Alabama, 36207, United States
Royal North Shore Hospital

Saint Leonards, New South Wales, 2065, Australia
SPICA Clinical

Columbia, South Carolina, 29322, United States
Southern Clinical Trials Ltd

Beckenham, Christchurch, Canterbury, 8013, New Zealand
Southern Clinical Trials Tasman

Nelson, 7011, New Zealand
University of The Sunshine Coast Morayfield

Morayfield, Queensland, 4506, Australia
University of The Sunshine Coast South Brisbane

South Brisbane, Queensland, 4101, Australia
University of the Sunshine Coast Clinical Trial Centre

Sippy Downs, Queensland, 04556, Australia
Weill Cornell Medical College

New York, New York, 10021, United States

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