OVERWEIGHT OR OBESITY

This study is testing whether a new drug called MET097, given as a monthly injection after initial weekly doses, helps people with obesity or overweight lose weight. About 250 adults will receive either the drug or a placebo (inactive shot) for over a year to see which is more ef…

This early-stage study is testing the safety and side effects of a new weight management drug called IBI3032 in people who are overweight or have obesity. The trial involves 79 participants who will receive either the drug or a placebo over 4 weeks. Researchers are primarily chec…

This study is testing a once-daily pill called orforglipron to see if it can reduce breathing pauses during sleep (sleep apnea) and help with weight loss in adults who are overweight or have obesity. It will involve about 600 people, including those who do and do not use a standa…

This study is testing whether a new weekly injection called MET097 helps people with obesity or overweight lose weight compared to a placebo shot. About 225 adults will receive either the drug or a placebo for 28 weeks to see which group loses more weight and has fewer side effec…

This large, late-stage study is testing whether a once-daily oral medication called orforglipron can help adults with obesity or overweight lose weight and improve related health conditions like high blood pressure or cholesterol. Over 3,100 participants will take the drug or a p…

This large, late-stage study is testing whether a new once-daily pill called orforglipron is as safe and effective as standard insulin injections for adults with type 2 diabetes who also have obesity or are overweight and are at higher risk for heart problems. It will involve abo…

This study aims to see if a specific eating plan is better than a prescription medication for reducing liver fat and scarring. Researchers will compare a Mediterranean diet combined with intermittent fasting against the weight-loss drug naltrexone/bupropion (Mysimba®). The goal i…

This study is testing whether adding a CPAP breathing machine to a standard diet and exercise program can better prevent diabetes in overweight adults with prediabetes and sleep apnea. Researchers want to see if treating sleep apnea improves blood sugar and heart health more than…

This study aims to understand how the liver's energy production changes in people with fatty liver disease (NASH) who are undergoing weight loss surgery. Researchers will measure how the liver burns fat and makes sugar in 30 participants before their surgery. The goal is to see i…

This study aims to collect and store biological samples from 500 people with obesity. The goal is to build a repository of blood, urine, and tissue to help researchers understand why weight loss treatments sometimes work or fail, and why weight is often regained. This is an obser…

This study aimed to see how gut bacteria and blood chemicals change in overweight or obese adults following a special low-carb diet. Participants would provide stool and blood samples as they lost weight. The goal was to understand how diet affects gut health during weight loss.