OVERWEIGHT OR OBESITY

This study tests a new medicine called MET097, given as a weekly shot for 12 weeks and then monthly, to see if it helps people with obesity or overweight lose weight safely. About 268 adults who do not have type 2 diabetes will take part. The main goal is to measure weight change…

This study tests a new drug called MET097, given as a weekly shot, to help people with obesity or overweight lose weight. About 225 adults will receive either the drug or a placebo for 28 weeks. The main goal is to see how much weight they lose compared to those on placebo.

This phase 3 trial tests a once-daily medication called orforglipron in 600 adults with moderate-to-severe obstructive sleep apnea (OSA) who are also overweight or have obesity. The study has two parts: one for people who cannot or will not use a CPAP machine, and another for tho…

This early-stage study tests the safety of a new drug called IBI3032 in 79 healthy adults who are overweight or obese. Participants receive multiple doses over 4 weeks to see how the drug behaves in the body and if it causes side effects. The goal is to gather initial safety data…

This study tests a once-daily oral medication called orforglipron for weight loss in adults with obesity or overweight who also have weight-related conditions like high blood pressure or sleep apnea. About 3,100 participants will take either the drug or a placebo for 72 weeks, wi…

This study tests whether a Mediterranean diet combined with intermittent fasting can reduce liver scarring better than the weight-loss medication naltrexone/bupropion. About 70 adults with overweight, type 2 diabetes, or other heart-related risks and moderate liver fibrosis will …

This study looks at whether adding CPAP (a machine that helps you breathe during sleep) to a lifestyle program can improve blood sugar and blood pressure more than lifestyle changes alone. Researchers are studying 174 overweight or obese adults with prediabetes and sleep apnea. T…

This study looks at how compounds in strawberries and raspberries (polyphenols) interact with gut bacteria to reduce inflammation. Overweight adults with mild inflammation will eat berries or a fiber supplement for 4 weeks. Researchers will measure changes in blood and stool mark…

This observational study collects blood, urine, and tissue samples from 500 obese adults to learn more about obesity, weight loss, and why some people regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up to …

This study looks at ways to help people in rural Pennsylvania become more physically active. It includes 880 adults who are overweight, have type 2 diabetes, or are not active. Researchers will track activity levels using questionnaires and wearable devices to see what works best…

This study looks at how the liver burns fat and produces sugar in people with NASH (a serious fatty liver disease) who are planning to have weight-loss surgery. Researchers will use special scans to measure these liver functions before and after surgery. The goal is to understand…

This study aimed to see how gut bacteria and blood chemicals change in overweight or obese adults following a special low-carb diet. Participants would provide stool and blood samples as they lost weight. The goal was to understand how diet affects gut health during weight loss.