ELDERLY

This study compares two seasonal flu vaccines—one with an extra ingredient to boost the immune response (adjuvanted) and one without—in 200 adults aged 65 and older who also have chronic medical conditions like diabetes or heart disease. The goal is to see which vaccine triggers …

This early-stage study tests whether a combination of two experimental drugs, GI-102 and GIB-7, can improve immune function and other signs of aging in healthy adults and cancer survivors. About 15 participants will receive the treatment or a placebo for 8 weeks. The goal is to s…

This study tests whether giving fluids tailored to each patient's needs, guided by a lung water monitor, can prevent acute kidney injury in elderly people with mild-to-moderate kidney disease who undergo a heart procedure called coronary angiography. About 320 participants aged 6…

This study tests whether metformin, a common diabetes medicine, can improve memory and thinking in overweight or obese older adults with mild cognitive impairment (MCI). Researchers will give metformin or a placebo to 54 people aged 60-75 for 26 weeks. They will use brain scans a…

This study tests a friendly AI chatbot that guides people through telling their life stories to boost emotional well-being. It includes healthy adults, older adults aged 65+, and adults with mental health conditions living in care homes. The chatbot helps create a personal "life …

This study looks at whether adding local muscle vibration to standard rehabilitation can help elderly patients (75+) recover muscle strength, mobility, and reduce pain after hip fracture surgery. About 25 participants will receive vibration sessions five times a week for four wee…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea. About 668 participants will use PAP therapy and be tested on memor…

This study looks at whether it is safe to stop antibiotics early in people aged 65 and older who are hospitalized with a viral infection like the flu or RSV. Many of these patients get antibiotics even though a bacterial infection is rare, which can cause side effects and lead to…

This study looks at why some older adults improve their muscle strength with exercise while others do not. Researchers will track 900 people aged 60 and older to find biological markers that predict individual responses to different types of physical activity. The goal is to crea…

This study looks at the best way to prevent another stroke in older adults (over 60) who have a small hole in the heart called PFO and had a stroke from an unknown cause. Researchers will compare three treatments: closing the hole with a device, taking blood thinners, or taking a…

This study watches 1,200 older adults (65+) before and after surgery to learn why some get complications like confusion (delirium). Researchers collect blood samples and health info to build a risk prediction model. The goal is to better understand and eventually prevent these pr…

This study looks at whether group or solo singing is a practical activity for older adults with coronary artery disease. Researchers want to see if people will stick with it and if it could lower heart disease risk. The study involves 32 participants and focuses on attendance and…

This study looks at whether simple blood tests and brain scans can help predict which older adults with memory loss or frailty will need to visit the emergency room within six months. Researchers will follow 110 people over age 64 who have trouble with daily activities. The goal …

This study looks at how well the body digests and uses protein from peas in healthy young (18-23) and older (65-75) adults who are either vegetarian or omnivore. Researchers will measure protein breakdown and amino acid absorption after a pea-based meal. The goal is to understand…

This study looks at whether elderly men (70+) with prostate cancer who have been on hormone therapy for over 3 years can stop taking it. The idea is that their bodies may already be permanently unable to produce testosterone, so the shots may no longer be needed. Researchers will…

This study is testing whether a team of different specialists (like surgeons, cancer doctors, and geriatricians) can create better, personalized treatment plans for older adults (ages 60-90) with lung cancer. The goal is to see if this team approach helps people live longer witho…