Can a new sedative combo make Children's gastroscopy safer?
NCT ID NCT07748884
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This trial tests whether a combination of esketamine and remimazolam can reduce breathing problems in children aged 6 to 12 during gastroscopy, compared to the traditional propofol-based sedation. Children have smaller airways and lower oxygen reserves, making them more prone to low oxygen levels during sedation. The study will measure how often respiratory issues like low oxygen or coughing occur, and also check how well the sedation works and how quickly children recover.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Esketamine combined with remimazolam, compared with fentanyl and propofol
- What this could lead to
- If this combination works, it could offer a safer sedation option for children undergoing gastroscopy, with fewer breathing complications and faster recovery.
- What could go wrong
- This is a single-center study with 120 children, so results may not apply broadly. The new combo might not prove safer than propofol, and any sedative carries risks like low oxygen or allergic reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou, Wenzhou, Zhejiang
Zhejiang, China
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