Could probiotics stop a deadly infection from coming back in liver disease?
NCT ID NCT07686861
First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time
Summary
This study tests whether adding a probiotic (Bifidobacterium quadruple live tablets) to standard antibiotics can better control and prevent the return of spontaneous bacterial peritonitis (SBP) in people with cirrhosis. SBP is a serious infection of the abdominal fluid that often recurs. The trial enrolls 360 adults with cirrhosis and SBP, giving them either the probiotic or a placebo alongside antibiotics for 24 weeks, then following them for another 24 weeks to see if the probiotic reduces recurrence and extends survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Bifidobacterium quadruple live tablets
- What this could lead to
- If it works, this could point toward a simple probiotic supplement to prevent dangerous abdominal infections in people with cirrhosis, potentially reducing hospitalizations and improving survival.
- What could go wrong
- This is a Phase 4 trial, but probiotics may not outperform placebo in preventing recurrence. Results may not apply to all cirrhosis patients, and long-term safety data are limited.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beijing You'an Hospital,Capital Medical University
Beijing, China
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First Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
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Fuyang People's Hospital
Fuyang, Anhui, China
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Guangzhou Eighth PeoPle's Hospital,Guangzhou medical University
Guangzhou, Guangdong, China
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Guigang City People's Hospital
Guigang, Guangxi, China
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Mengchao Hepatobiliary Hospital Of Fujian Medical University
Fuzhou, Fujian, China
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Ningbo No.2 Hospital
Ningbo, Zhejiang, China
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Peking University First Hospital
Beijing, China
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Peking University Shenzhen Hospital
Shenzhen, Guangdong, China
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Shanghai Public Health Clinical Center
Shanghai, China
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Shanxi Bethune Hospital
Taiyuan, Shanxi, China
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Shenzhen Third People's Hospital
Shenzhen, Guangdong, China
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Sichuan Provincial People's Hospital
Chengdu, Sichuan, China
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The Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, China
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The Affiliated People's Hospital of Ningbo University
Ningbo, Zhejiang, China
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The First Affiliated Hospital , Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
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The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
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The First Affiliated Hospital of Xiamen University
Xiamen, Fujian, China
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The First Hospital of Lanzhou University
Lanzhou, Gansu, China
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The First People's Hospital of Yunnan Province
Kunming, Yunnan, China
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The Second Affiliated Hospital of Chongqing Medical University
Chongqing, China
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The Second Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China
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The Second Affiliated Hospital of Xi'an Jiaotong University
Xian, Shanxi, China
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The Second Hospital of Nanjing
Nanjing, Jiangsu, China
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The Sixth People's Hospital Of Shenyang
Shenyang, Liaoning, China
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The Third Hospital Of Qinhuangdao
Qinhuangdao, Hebei, China
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West China Hospital of Sichuan University
Chengdu, Sichuan, China
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Xiamen Hospital of T.C.M.
Xiamen, Fujian, China
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Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University
Yantai, Shandong, China
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Yantai Qishan Hospital
Yantai, Shandong, China
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