Peking University First Hospital

This trial tests whether sirolimus (rapamycin), an immune-suppressing drug, can safely raise platelet counts in people with antiphospholipid antibodies and persistent low platelets. Participants are randomly assigned to receive sirolimus or a placebo for six months, and those who…

This study tests whether carefully managing body temperature during major cancer surgery can lower the risk of postoperative delirium (sudden confusion) and improve long-term survival in patients aged 65 and older. About 4,000 participants will be randomly assigned to either rout…

This study is testing a 14-day treatment for Helicobacter pylori, a stomach infection that can cause ulcers and cancer. The treatment uses two drugs, vonoprazan and clarithromycin, and is guided by a stool test to check if the bacteria are resistant to clarithromycin. The goal is…

This study tests whether combining a special PET scan (CAIX PET/CT) with standard therapy can better control advanced kidney cancer. About 70 adults with recurrent or metastatic clear cell renal cell carcinoma will receive targeted therapy and immunotherapy, plus precise radiatio…

This study looks at whether adding a precise type of radiation (SABR) to standard drug therapy (targeted therapy plus immunotherapy) can help people with recurrent or metastatic kidney cancer live longer without their disease getting worse. About 300 participants will be enrolled…

This study looks at whether a combination of radiation and immunotherapy works better than standard chemotherapy after surgery for a rare type of kidney cancer called upper tract urothelial carcinoma. About 178 patients with high-risk features will be followed to see which treatm…

This phase 2 trial is testing whether a targeted drug called disitamab vedotin, given together with radiation therapy, can prevent cancer recurrence in people with HER2-positive upper tract urothelial cancer who are at high risk after surgery. About 60 participants will either re…

This phase 2 trial is testing whether a combination of rezvilutamide (a hormone-blocking pill) and standard hormone therapy can prevent high-risk salivary duct cancer from returning after surgery and radiation. About 37 participants with androgen receptor-positive cancer will rec…

This study tests a small, AI-powered ECG device that looks like a stick of gum to help people with moderate-to-advanced chronic kidney disease monitor their potassium levels at home. Participants will use the device at least twice a week and receive alerts if levels are abnormal.…

This study will test a new type of PET/CT scan that uses a special tracer to find BCMA, a protein on myeloma cells. The goal is to see if this scan can more accurately detect active myeloma throughout the body compared to standard methods. About 300 people with suspected or known…

This study is testing a new radioactive probe called PFD3, used with a PET/CT scan, to see if it can better find and assess small cell lung cancer (SCLC) by targeting a protein called DLL3 found on cancer cells. About 30 adults with SCLC will receive both a standard FDG scan and …

This study tests whether a newer biopsy method (perilesional biopsy) can find aggressive prostate cancers as well as the standard combination of targeted and systematic biopsies. About 640 men with a single suspicious MRI lesion will be randomly assigned to one of two biopsy appr…

This study compares two biopsy methods in 572 men who have multiple suspicious spots on MRI but have never had a prostate biopsy. One method combines targeted biopsy with a wider sampling around each spot (perilesional biopsy), while the other combines targeted biopsy with standa…

This study tests whether a new type of PET scan (68Ga-Pentixafor) can accurately identify which adrenal gland is overproducing hormones in patients with both aldosterone and cortisol excess. About 130 adults will receive the scan and standard vein sampling, then researchers compa…

This study is testing a new imaging agent called 18F-T2, which is designed to highlight tumors that produce a protein called CAIX. About 200 adults with various cancers (like kidney, lung, or breast cancer) will receive an injection of 18F-T2 and then undergo a PET/CT scan. The g…

This study tests a new imaging agent called 68Ga-NB381 to see if it can find multiple myeloma tumors more accurately than current scans. The probe targets a protein (CD38) found on cancer cells. About 30 adults with suspected or confirmed multiple myeloma will receive the probe a…

This study compares two prostate biopsy techniques to see which one better detects clinically significant prostate cancer. About 592 men with a suspicious MRI lesion will be randomly assigned to receive either targeted plus perilesional biopsy or targeted plus systematic biopsy. …

This study tests a new radioactive probe called 68Ga-PFA2 for PET scans. It targets a protein called annexin A2, which is found at high levels in many cancers and helps them spread. Researchers want to see if this probe can find metastases in lung cancer patients better than curr…

This study is developing an artificial intelligence tool to automatically detect adrenal nodules in low-dose chest CT scans taken during routine physical exams. Researchers will collect 600 chest CT images, train the AI to recognize adrenal nodules, and measure its diagnostic acc…

This study is testing whether a computer program (deep learning) can accurately tell the difference between early-stage (T1-T2) and more advanced (T3) kidney cancer on CT scans. Researchers will train the AI on 1,000 patients' scans and check its accuracy. If it works, the tool c…

This study tests whether a personalized form of transcranial magnetic stimulation (TMS) can improve motor and non-motor symptoms in people with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy. Fifty participants will receive 10 days of targeted TMS…

This study tests a drug called anrikefon for treating internal pain after laparoscopic (keyhole) surgery. It is given through a pump that lets patients control their own pain relief. The trial includes 140 adults having colorectal surgery. The goal is to see if anrikefon provides…

This study tests whether giving dexmedetomidine and esketamine during and after surgery can help patients recover better. 316 adults having general anesthesia will receive one or both drugs, and their recovery quality will be measured using a 15-item questionnaire. The goal is to…

This study tests whether a nose spray containing two drugs, dexmedetomidine and esketamine, can reduce pain after tonsil and adenoid surgery in children aged 3 to 7. About 160 kids will receive either the drug combo or a placebo spray right after anesthesia. Researchers will trac…

This study tests whether a structured education program, combined with regular follow-up visits, can help adults with type 1 diabetes better control their blood sugar. Researchers at Peking University First Hospital will enroll 150 participants and provide courses on diet, exerci…

This study looks at severe allergic reactions that can happen during surgery. Researchers want to better diagnose these reactions and find out what causes them, so they can prevent future episodes. About 115 people who have had a suspected allergic reaction in the operating room …

This study follows 214 people in China with multiple system atrophy, a rare and fast-worsening brain disease that affects movement and automatic body functions. Researchers will track symptoms over time to learn how the disease progresses and what factors influence it. The goal i…

This study is testing a new ultrasound technique called super-resolution ultrasound microvascular imaging (SRUMI) to see if it can predict how peripheral artery disease (PAD) will progress. Researchers will scan the legs of 300 people with PAD and compare the images to standard t…

This study looks at whether a lower daily dose of aspirin (50 mg) is as effective and safer than the standard dose (100 mg) for preventing heart attacks and strokes in Chinese patients aged 60 and older with heart disease. Researchers will follow over 5,400 participants for up to…

This study is working to create a system that can identify people at high risk for type 1 diabetes. Researchers will follow 340 people, including patients with type 1 diabetes and their close relatives, for four years. They will collect blood, urine, and stool samples each year t…

This study aims to develop and test an AI model that analyzes prostate MRI scans to predict whether a cancer is aggressive (clinically significant). Researchers will use data from 3,000 patients who had both an MRI and a biopsy. The goal is to create a tool that helps doctors dec…

This study tests whether moving patients to the recovery room before removing their breathing tube frees up the operating room faster after robot-assisted surgery. Researchers will compare two approaches in 218 adults: removing the tube in the operating room versus in the post-an…

This study aims to build and test an AI-based early warning system to screen men aged 50 and older for prostate and bladder cancer. Researchers will enroll 3,000 male residents of Beijing, measuring PSA levels and using AI to flag high-risk individuals. No drugs or devices are gi…

Primary aldosteronism is a common but often missed cause of high blood pressure. This study will analyze blood, urine, and adrenal tissue from 400 people to find biological markers that could lead to earlier diagnosis. Researchers hope to use advanced lab techniques and machine l…

Inflammatory bowel disease (IBD) is a lifelong condition with no cure. Biologic drugs are a first-line treatment, but they fail in 30-50% of patients. This study will collect data from 200 IBD patients to build a predictive model using clinical features and machine learning. The …

This study is testing a new, minimally invasive brain stimulation technique for people with cerebellar cognitive affective syndrome (CCAS), a condition that causes problems with thinking, mood, and movement. The researchers are enrolling 200 participants with Cushing's syndrome-r…

This study is testing whether certain substances in urine and blood can predict acute kidney injury and chronic kidney disease after radical nephrectomy (complete kidney removal). Researchers will monitor 60 adults undergoing this surgery, collecting samples at several time point…