Could a transplant drug tame stubborn low platelets in antiphospholipid syndrome?
NCT ID NCT06722586
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This trial tests whether sirolimus (rapamycin), an immune-suppressing drug, can safely raise platelet counts in people with antiphospholipid antibodies and persistent low platelets. Participants are randomly assigned to receive sirolimus or a placebo for six months, and those who do not respond may receive sirolimus for an additional three months. The main goal is to see if sirolimus leads to a meaningful increase in platelet levels compared to placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Sirolimus (rapamycin)
- What this could lead to
- If it works, sirolimus could offer a new, steroid-sparing option to manage low platelet counts in people with antiphospholipid antibodies.
- What could go wrong
- This is a Phase 4 trial with 84 participants. Sirolimus may not improve platelet counts more than placebo, and side effects like mouth sores, infections, or high cholesterol are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beijing Chao-Yang Hospital
RECRUITINGBeijing, 100020, China
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Beijing Shijitan Hospital
RECRUITINGBeijing, China
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Peking University First Hospital
RECRUITINGBeijing, 100034, China
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Peking University Third Hospital
RECRUITINGBeijing, 100083, China
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People's Hospital of Xinjiang Uygur Autonomous Region
RECRUITINGÜrümqi, Xinjiang, 830001, China
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Qilu Hospital of Shandong University
RECRUITINGJinan, Shangdong, 250012, China
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Shanghai Renji Hospital
RECRUITINGShanghai, 200001, China
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The 1st Affiliated Hospital of Wenzhou Medical University
RECRUITINGWenzhou, Zhejiang, 325015, China
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West China Hospital, Sichuan University
RECRUITINGChengdu, Sichuan, 610041, China
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Xiangya Hospital of Central South University
RECRUITINGChangsha, Hunan, 410013, China
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