New combo aims to stop rare Cancer's return after surgery
NCT ID NCT06210490
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing whether a targeted drug called disitamab vedotin, given together with radiation therapy, can prevent cancer recurrence in people with HER2-positive upper tract urothelial cancer who are at high risk after surgery. About 60 participants will either receive the combination treatment or be closely watched. The study will track how long they remain cancer-free and monitor side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Disitamab vedotin (a targeted antibody-drug conjugate) and radiotherapy
What this could lead to
If successful, this combination could offer a new option to reduce the chance of cancer returning after surgery for patients with HER2-positive upper tract urothelial cancer.
What could go wrong
This is a small, early-phase study with only 60 participants, so results may not apply broadly. The drug can cause side effects like nerve damage or low blood counts, and it is not yet proven to improve survival.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Peking University First Hospital
RECRUITINGBeijing, Beijing Municipality, 100034, China
Contact
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••