Could a simple mouthguard replace CPAP in a pinch?

NCT ID NCT05939934

Recruiting now Disease control Sponsor: University Hospital, Angers Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a custom mouthpiece (mandibular advancement device) can help people with obstructive sleep apnea when they temporarily stop using their CPAP machine. Forty adults who normally use CPAP will either use the mouthpiece or nothing during a two-week CPAP break. Researchers will measure changes in sleepiness, blood pressure, and heart function to see if the mouthpiece reduces the negative effects of stopping CPAP.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mandibular advancement device (MAD)
What this could lead to: If it works, this could offer a temporary backup option for sleep apnea patients who need to stop CPAP for a short time.
What could go wrong: This is a small, early-stage trial with only 40 participants. The MAD may not fully prevent symptom return or heart issues during CPAP withdrawal.

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOTHELIAL DYSFUNCTION SLEEP APNEA, OBSTRUCTIVE

Contacts and locations

Locations

Angers University Hospital
RECRUITING

Angers, 49100, France

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