ENDOTHELIAL DYSFUNCTION

This study is testing if a short, daily breathing exercise is as good as a standard walking program for lowering high blood pressure in postmenopausal women. Researchers will compare a 5-minute breathing training routine against 150 minutes per week of brisk walking over 3 months…

This study is testing whether a simple, at-home arm cuff exercise can protect the tiny blood vessels of frail older adults from damage caused by physical stress. Researchers want to see if repeatedly inflating a blood pressure cuff on the arm for two weeks makes these vessels mor…

This early-stage study is testing whether repeated injections of an experimental drug called EO2002 directly into the eye are safe for people with corneal swelling. The trial will enroll 12 adults whose vision is cloudy due to conditions like Fuchs' dystrophy or swelling after ca…

This study is testing whether a daily natural supplement can improve the health of blood vessels and reduce markers in the blood linked to aging and future heart disease. Healthy adults will take the supplement for six weeks while researchers measure changes in specific blood mar…

This study is testing if taking the cholesterol-lowering drug atorvastatin before a brain aneurysm procedure can prevent strokes and artery narrowing. It will involve 354 patients in China who are getting a special stent called a flow diverter. Patients will be randomly assigned …

This study is testing whether two common cholesterol-lowering medications (statins) affect testosterone levels and erectile function in men aged 40-65 who are at high risk for heart disease. Researchers will compare two different statins over six months, measuring hormone levels …

This study is testing whether a prescription smartwatch app called NightWare can improve sleep and heart health in Veterans with PTSD. The app detects when a nightmare is happening using heart rate and movement, and gently interrupts it. Researchers will enroll 125 Veterans to se…

This study aims to understand how chemotherapy or radiation given before colorectal cancer surgery affects patients' blood vessels and healing. Researchers will compare 68 patients—half who received pre-surgery treatment and half who went straight to surgery—by examining tissue s…

This study aims to understand how poor sleep might connect difficult childhood experiences to early signs of blood vessel problems in young adults. Researchers will first observe 70 young adults, measuring their sleep and blood vessel health. Then, some participants with poor sle…

This study aims to better understand how high levels of a specific blood fat called Lipoprotein(a), or Lp(a), affect the stiffness of arteries and the function of the heart over time. Researchers will observe 300 adults for one year, measuring artery health, heart function, and t…

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to develop new laboratory tests and study genes, proteins, and other substances in the body. The goal is to build a resour…

This study aims to understand why people with spinal cord injuries have a higher risk of heart attacks and strokes. Researchers will compare blood vessel function in men with recent spinal injuries who have low versus normal testosterone levels. By measuring how well blood vessel…

This study aims to understand how blood vessel health is connected to erectile dysfunction (ED) and heart disease risk. Researchers will measure blood vessel function in men with ED before and after they start standard treatments like ED pills or testosterone therapy. The goal is…

This study aims to understand why women who had diabetes during pregnancy (gestational diabetes) remain at higher risk for future heart problems, even after their blood sugar returns to normal. Researchers will study 40 women to see if a specific protein in blood vessels and thei…

This study aims to understand how using e-cigarettes (vaping) affects blood vessel health and causes inflammation in young adults. Researchers will compare young people who vape regularly with those who don't, measuring blood vessel function before and after taking an anti-inflam…

This study aims to understand why people with spinal cord injuries have a higher risk of heart attacks and strokes. Researchers will measure how well blood vessels relax and increase blood flow in 40 adults, comparing those with and without spinal cord injuries. They will also te…

This study aims to understand exactly how exercise training improves the function of tiny blood vessels in the muscles of people with obesity and metabolic syndrome. Researchers will study 25 sedentary adults, using specialized techniques to measure chemical signals and blood flo…