ENDOTHELIAL DYSFUNCTION

This study tests whether taking atorvastatin (a cholesterol-lowering drug) before a brain stent procedure can prevent strokes and other serious events. About 354 adults with brain aneurysms will receive either the drug or a placebo before and after stent placement. Researchers wi…

This study tests a daily oral supplement made from natural ingredients and L-citrulline to see if it can improve blood vessel function and reduce markers of aging and heart disease risk. Healthy adults aged 18 and older will take the supplement for 6 weeks. Researchers will measu…

This study tests a prescription wrist device called NightWare in 125 veterans with PTSD who have frequent nightmares. The device aims to improve sleep quality, which may also reduce the risk of heart disease. Researchers will measure sleep, blood vessel health, and nervous system…

This study tests whether galantamine, a drug that boosts the body's calming nervous system, can improve blood vessel function and reduce harmful oxidative stress in African Americans. Researchers will measure changes in blood vessel dilation and markers of cell damage over three …

This study tests a new drug called TB-500 in 80 adults with stable heart disease to see if it is safe and tolerable. Participants will receive either TB-500 or a placebo, and researchers will monitor side effects and measure markers of blood vessel health and inflammation. The go…

This study tests whether a custom mouthpiece (mandibular advancement device) can help control sleep apnea symptoms and protect heart health when people temporarily stop using their CPAP machine. About 40 adults who have used CPAP for over a year will be enrolled. The goal is to f…

This study tests whether a simple, 5-minute daily breathing exercise (inspiratory muscle strength training) can lower blood pressure and improve blood vessel health in postmenopausal women aged 50 and older with high blood pressure. It compares this breathing exercise to standard…

This study looks at whether cholesterol-lowering statins affect male hormone levels and erectile function in men aged 40-65 who are at high risk for heart problems. Researchers will give 150 men either pitavastatin or rosuvastatin and monitor their erections, hormone levels, and …

This early-stage study tests the safety of an experimental drug called EO2002, given as an injection into the eye, for people with corneal edema (swelling of the clear front part of the eye). The study involves 12 adults with corneal swelling caused by Fuchs' dystrophy or after c…

This study looks at how a specific blood fat called lipoprotein(a) might affect the stiffness of arteries, the health of blood vessel linings, and the heart's ability to pump. Researchers will follow 300 adults aged 18-75 for one year, measuring these factors and tracking any hea…

This study looks at why obesity damages small blood vessels in muscle, leading to health problems like heart disease. Researchers will measure harmful molecules and blood flow in the muscles of 25 obese adults before and after an 8-week exercise program. The goal is to understand…

This study looks at whether inflammation from e-cigarette use harms blood vessel function in young adults aged 18-24. Researchers will compare vapers and non-vapers by measuring skin blood flow after a mild heat test, with and without an anti-inflammatory drug. The goal is to und…

This study looks at how difficult childhood experiences and sleep problems may harm blood vessel function in young adults aged 18-29. Researchers will measure sleep quality and blood vessel health in 70 participants. Some will then join a 6-week sleep improvement program to see i…

This study looks at why men with spinal cord injury have a higher risk of heart attacks and strokes. Researchers will test blood vessel function in 48 men with recent spinal cord injury and low testosterone. They aim to understand if low testosterone damages the cells lining bloo…

This study looks at why women who had gestational diabetes (diabetes during pregnancy) may have higher heart disease risk years later. Researchers will test how a natural chemical called endothelin-1 affects small blood vessel function, and whether physical activity or sitting to…

This study looks at how chemotherapy or radiation given before surgery for colorectal cancer affects small blood vessels and scar tissue. Researchers will compare 34 patients who had pre-surgery treatment with 34 who went straight to surgery. The goal is to understand if these ch…

This study looks at how spinal cord injury (SCI) may damage the cells lining blood vessels, increasing the risk of heart attacks and strokes. Researchers will measure blood vessel function in 40 adults with and without SCI. The goal is to understand the underlying causes so bette…

This study looks at blood vessel health in men aged 30–50 with erectile dysfunction or low testosterone. Researchers use a device called EndoPAT to measure how well blood vessels respond to changes in blood flow. They will check again 3 to 6 months after starting daily low-dose E…

This study collects blood and urine samples from 1,000 healthy volunteers and patients with heart or lung conditions. Researchers will analyze genes, proteins, and other substances to develop new lab tests and better understand diseases. Participants must be 18 or older and can p…

This study looks at whether a simple technique called ischemic conditioning can protect small blood vessels in frail older adults during intense exercise. Sixty people aged 65 to 85 will use a blood pressure cuff at home for two weeks. Researchers will measure blood vessel functi…

This study looks at how changes in blood flow to the brain affect breathing during sleep in healthy adults. Researchers will measure breathing responses to low oxygen and high carbon dioxide levels under normal and low-oxygen sleep conditions. The goal is to better understand bre…