ENDOTHELIAL DYSFUNCTION

This study tests whether a drug called galantamine can improve blood vessel function and reduce harmful stress in the blood vessels of African Americans. Researchers will measure changes in blood flow and markers of cell damage over three months. The goal is to find a new way to …

This study tests whether a custom mouthpiece (mandibular advancement device) can help people with obstructive sleep apnea when they temporarily stop using their CPAP machine. Forty adults who normally use CPAP will either use the mouthpiece or nothing during a two-week CPAP break…

This early-stage trial is testing an experimental drug called TB-500 in 80 adults with stable atherosclerotic cardiovascular disease. The main goal is to see if the drug is safe and tolerable. Researchers will also measure changes in blood vessel function and inflammation as earl…

This study looks at whether two common statins (pitavastatin and rosuvastatin) affect male sex hormones and erectile function in men aged 40-65 with high heart risk. Researchers will monitor 150 men for 6 months, checking hormone levels, erectile function, and blood vessel health…

This study tests whether taking atorvastatin (a cholesterol-lowering drug) before and after a brain stent procedure can prevent strokes and other serious events. About 354 adults with brain aneurysms will be randomly assigned to receive either atorvastatin or a placebo. The goal …

This study compares a 5-minute daily breathing exercise (IMST) to brisk walking for lowering blood pressure in postmenopausal women aged 50 and older with above-normal blood pressure. Researchers will measure changes in blood pressure and blood vessel function after 3 months of t…

This early-stage trial tests the safety of injecting special human cells (EO2002) into the eye to treat corneal swelling. Twelve adults with corneal edema from Fuchs' dystrophy or after cataract surgery will receive multiple injections, with or without Ripasudil eye drops. The ma…

This study tests a prescription wrist device called NightWare that detects when a veteran with PTSD is having a nightmare and gently disrupts it without waking them. Researchers want to see if better sleep from fewer nightmares can also improve blood vessel and heart health. 125 …

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to study genes, proteins, and other substances in the lab. The goal is to support basic and translational research that co…

This study looks at how a type of fat in the blood called lipoprotein(a), or Lp(a), affects the stiffness of arteries, the health of blood vessel linings, and the heart's ability to pump. Researchers will follow 300 adults for one year, measuring these factors and tracking heart …

This study looks at how chemotherapy or radiation before colorectal cancer surgery affects tiny blood vessels and scarring in skin tissue, and whether this leads to more complications. Researchers will compare 34 patients who had pre-surgery therapy with 34 who went straight to s…

This study is testing whether a simple finger device called EndoPAT can measure blood vessel function in men aged 30–50 with erectile dysfunction or low testosterone. About 120 men will use the device before and after taking daily low-dose ED medication or testosterone therapy. T…

This study looks at whether inflammation caused by e-cigarette use harms blood vessel function in young adults aged 18-24. Researchers will compare chronic vapers to non-users, measuring blood vessel responses after giving an anti-inflammatory drug or placebo. The goal is to unde…

This study looks at why women who had gestational diabetes (diabetes during pregnancy) often have higher heart disease risk years later. Researchers will test how a natural chemical called endothelin-1 affects small blood vessels in 40 women who had a baby within the last 5 years…

This study looks at how exercise improves blood vessel function in people with obesity. Researchers will measure oxidative stress and blood flow in the muscle before and after an 8-week interval training program. The goal is to understand the role of a specific enzyme (NADPH oxid…

This study looks at how difficult childhood experiences and poor sleep might harm blood vessel function in young adults aged 18-29. Researchers will monitor sleep at home and test blood vessel health. Some participants will receive a 6-week sleep therapy program (CBT-i) to see if…

This study looks at why men with spinal cord injury often have low testosterone and how that might damage blood vessels, raising the risk of heart attacks and strokes. Researchers will test blood vessel function in 48 men with recent spinal cord injury and low testosterone. They …

This study looks at why blood vessels may not work as well after a spinal cord injury, which can raise the risk of heart attacks and strokes. Researchers will measure blood flow and study tiny particles from blood vessel cells in 40 adults with and without spinal cord injuries. T…

This study tests whether a simple, at-home procedure called ischemic conditioning can protect small blood vessels in frail adults aged 65-85. Participants use a blood pressure cuff to briefly restrict blood flow to one arm, then release it, repeating this for two weeks. Researche…