Can fixing sleep heal blood vessels after childhood trauma?

NCT ID NCT06454344

Recruiting now Knowledge-focused Sponsor: Nathaniel Jenkins Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how difficult childhood experiences and poor sleep might harm blood vessel function in young adults aged 18-29. Researchers will monitor sleep at home and test blood vessel health. Some participants will receive a 6-week sleep therapy program (CBT-i) to see if improving sleep can help blood vessels work better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cognitive Behavioral Therapy for Insomnia (CBT-i)
What this could lead to: If it works, this could point toward a way to improve blood vessel health in young adults with a history of childhood trauma by treating their sleep problems.
What could go wrong: This is a small, early-stage study with only 70 participants. The sleep therapy may not improve blood vessel function, and results may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

Aneurysm Inflammation inflammatory disease Parasomnias Psychological Trauma sleep disorder vascular ectasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVERSE CHILDHOOD EXPERIENCES ENDOTHELIAL DYSFUNCTION INFLAMMATION OXIDATIVE STRESS PSYCHOLOGICAL TRAUMA PSYCHOSOCIAL STRESSOR SLEEP SLEEP DISTURBANCE VASCULAR DILATATION

Contacts and locations

Locations

Integrative Laboratory of Applied Physiology and Lifestyle Medicine
RECRUITING

Iowa City, Iowa, 52242, United States

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