Vascular ectasia

This study tests an experimental drug called ATV-1601 in people with moderate to severe HHT, a condition that causes frequent nosebleeds and anemia. The trial has two parts: first, participants receive either the drug or a placebo to check safety and effectiveness; then, all elig…

This early-phase trial tests an experimental antibody called DIAG723 in 93 adults with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and frequent nosebleeds. The study will check if the drug is safe and how the body processes it, with…

This study follows 100 adults with hereditary hemorrhagic telangiectasia (HHT) who start taking blood thinners (anticoagulants or antiplatelets). Researchers compare the three months before treatment to the first three months on treatment, tracking bleeding events, iron levels, a…

This study tests a cryotherapy spray (Tru-Freeze) to treat gastric antral vascular ectasia (GAVE), a condition that causes bleeding in the stomach. Researchers will measure changes in hemoglobin levels and blood transfusion needs in 50 adults over 6 months. The goal is to see if …

This study tests a treatment called Hemoporfin photodynamic therapy for port-wine birthmarks. It involves injecting a drug that is activated by green light to target the birthmark. 84 adults aged 18 to 75 will receive up to 3 treatment cycles to see which light dose works best an…

This study tests a head-worn ultrasound device called SONAS that listens for bubble signals in the brain during a standard heart ultrasound. It aims to see if the device can accurately detect right-to-left shunts—abnormal connections between blood vessels—in adults with hereditar…

This study compares two laser treatments—Nd:YAG versus diode—both combined with injection sclerotherapy, for removing reticular veins and spider veins (telangiectasias) using the CLaCS technique. About 80 adults aged 18 to 60 with these veins will receive one of the two laser typ…

This early-phase trial tests a new nasal ointment called TOR-582, which contains sirolimus, in 27 adults with hereditary hemorrhagic telangiectasia (HHT) who have frequent nosebleeds. Participants apply the ointment inside their nostrils twice daily for 12 weeks, with different s…

This study looks at how to improve laser therapy for port-wine birthmarks in children. The goal is to reduce the number of treatments needed and make the therapy work better, especially for stubborn cases. About 200 children aged 2 months to 18 years will take part. Researchers w…

This study tests whether nintedanib, a drug already used for lung scarring, can reduce nosebleeds in people with hereditary hemorrhagic telangiectasia (HHT). About 48 adults with moderate to severe nosebleeds will take either nintedanib or a placebo twice daily for 16 weeks. The …

This study tests whether adding remimazolam to standard sedation (propofol and alfentanil) can lower the risk of low oxygen levels in high-risk patients during painless tracheoscopy. About 360 participants with serious health conditions (ASA class 3-4) will be randomly assigned t…

This study tests a CE-marked laser called ADVATx on port-wine stains, a type of birthmark. Twenty participants will receive one laser treatment per month for four months. Doctors will check how much the stain fades and ask patients about their satisfaction and any side effects li…

This study looks at how well people tolerate laser treatment for port wine birthmarks using an FDA-approved 532 nm laser. Fifteen adults with non-facial birthmarks will receive three monthly treatments, comparing the standard single high-energy pulse to multiple low-energy pulses…

This natural history study aims to collect data from 1,200 people with lymphatic anomalies—rare conditions affecting the body's lymph system—over many years. Researchers will track symptoms, perform genetic testing, and gather biospecimens to better understand why these condition…

This study creates a detailed registry of people with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and bleeding. Researchers will track participants over time to collect information on symptoms, treatments, and disease progression. T…

This study creates a large registry of people diagnosed with hereditary hemorrhagic telangiectasia (HHT), a condition causing abnormal blood vessels and bleeding. Researchers will collect medical records and annual health updates for up to 10 years to understand how the disease c…

This study looks at how abnormal blood vessel growth (angiogenesis) contributes to various skin diseases like rosacea, psoriasis, and certain tumors. Researchers will collect skin samples from 85 volunteers aged 16 and older to analyze markers of angiogenesis. The goal is to bett…

This study follows 400 pregnant women with rare blood vessel diseases (like HHT, Marfan syndrome, or lymphedema) to learn about serious pregnancy complications. Researchers will ask participants about their health during pregnancy and for 12 months after birth. The goal is to gat…

This study looks at how common stomach symptoms like pain and nausea are in people with Gastric Antral Vascular Ectasia (GAVE), a condition where stomach blood vessels enlarge and may bleed. Researchers will use a simple breath test done at home to check how well the stomach empt…

This University of California, Davis study is testing whether chocolate made from chardonnay grape leftovers (called marc) can improve blood vessel function and reduce oxidative stress. Five adults with higher body weight and slightly reduced blood vessel flexibility will eat dif…

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …

This study looks at how difficult childhood experiences and poor sleep might harm blood vessel function in young adults aged 18-29. Researchers will monitor sleep at home and test blood vessel health. Some participants will receive a 6-week sleep therapy program (CBT-i) to see if…

This study looks at how iron supplements, often given for anemia, affect the immune system in people with Hereditary Haemorrhagic Telangiectasia (HHT), a rare genetic disorder that causes frequent nosebleeds and abnormal blood vessels. About 155 adults with HHT will be divided in…