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Jaw muscle signals may predict unwanted tooth shifts from sleep apnea devices

NCT ID NCT06576310

Symptom relief Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study investigates whether measuring jaw muscle activity can predict dental changes caused by mandibular advancement devices (MADs) used for obstructive sleep apnea. About half of people stop using MADs due to unwanted tooth movements. Researchers will track 118 adults over six months, using surface electromyography and digital bite analysis to see if muscle patterns correlate with dental shifts. The goal is to identify who is at risk and tailor treatment to reduce side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a mandibular advancement device (MAD) — a custom oral appliance that moves the lower jaw forward to keep the airway open during sleep
What this could lead to
If successful, this could help dentists predict which sleep apnea patients will experience unwanted dental shifts from a mandibular advancement device, allowing for personalized adjustments and fewer treatment dropouts.
What could go wrong
This is an observational study, not a test of a new treatment. It focuses on predicting side effects, not on curing or controlling sleep apnea itself. Results may not apply to all patients or devices.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 118 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

patients with sleep apnea treated with a mandibular advancement device

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient with complete dentition (up to second molars) * Polysomnography or polygraphy * Diagnosis of OSA * Patient receiving OAM treatment at the Odontology Department of Toulouse University Hospital * Patient with contemporary panoramic and lateral cephalometric X-rays (common practice) taken at the time of orthotic treatment * Individual affiliated with or covered by a social security scheme * Voluntary, informed, written consent, signed by both participant and investigator (prior to inclusion and any necessary research-related examinations). Exclusion Criteria: * Inability to provide informed consent * Pregnant or breastfeeding patient * Patient with curators, guardians, or legal protection

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Conditions

The condition(s) this trial relates to.

Bites and Stings obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obstructive sleep apnea syndrome

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

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Contacts and locations

Locations

  • University Hospital of Toulouse

    RECRUITING

    Toulouse, France

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