Veterans study aims to crack the code on Hard-to-Treat sleep apnea
NCT ID NCT04118387
First seen Mar 31, 2026 · Last updated Jun 23, 2026 · Updated 17 times
Summary
This study looks at why central sleep apnea happens and how to treat it better. Researchers will test a combination of a drug (acetazolamide), extra oxygen, and a breathing machine (PAP therapy) in 200 veterans with this condition. The goal is to understand the body's breathing control systems so future treatments can be more effective.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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John D. Dingell VA Medical Center, Detroit, MI
RECRUITINGDetroit, Michigan, 48201-1916, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Acetazolamide plus supplemental oxygen plus positive airway pressure (PAP) therapy
What this could lead to
If successful, this study could point toward more effective combination treatments for central sleep apnea, especially in people with heart failure or those taking opioids.
What could go wrong
This is a small, early-phase mechanistic study focused on measuring breathing responses, not on proving long-term benefit. The treatments may not translate into better outcomes in larger trials.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.