Could a pill replace the CPAP machine for sleep apnea?
NCT ID NCT07635563
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests IHL-42X, a combination of two drugs (dronabinol and acetazolamide), in people with obstructive sleep apnea. The study aims to see if the drug can reduce the number of breathing pauses during sleep and improve daytime symptoms. Participants will receive different doses of IHL-42X or a placebo over several four-week periods. The goal is to find a safe and effective dose that could offer an alternative to current treatments like CPAP machines.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
IHL-42X (dronabinol and acetazolamide combination)
What this could lead to
If successful, this could offer a new medication option for people with obstructive sleep apnea, potentially reducing the need for CPAP machines.
What could go wrong
This is a Phase 2 trial with a small number of participants, so results may not apply to everyone. The drug may cause side effects or prove no better than placebo.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Locations
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CNS Healthcare - Jacksonville
Jacksonville, Florida, 32256, United States
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CNS Healthcare - Memphis
Memphis, Tennessee, 38119, United States
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CNS Healthcare Orlando
Orlando, Florida, 32801, United States
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CTI Clinical Research Center
Cincinnati, Ohio, 45212, United States
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Conquest Research/Neurotrials
Winter Park, Florida, 32789, United States
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Exalt Clinical Research
Chula Vista, California, 91910, United States
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FutureSearch Trials of Dallas
Dallas, Texas, 75251, United States
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Intrepid Research
Cincinnati, Ohio, 45245, United States
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Palm Beach Research Center
West Palm Beach, Florida, 33409, United States
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Sleep Therapy & Research Center
San Antonio, Texas, 78229, United States
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Tandem Clinical Research
Marrero, Louisiana, 70072, United States
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Teradan Clinical Trials LLC
Brandon, Florida, 33511, United States
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Velocity Clinical Research, Anderson
Anderson, South Carolina, 29621, United States
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Velocity Clinical Research, Rockville
Rockville, Maryland, 20854, United States
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