Could a pill replace the CPAP machine for sleep apnea?

NCT ID NCT07635563

Recruiting now Disease control Sponsor: Incannex Healthcare Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 4 times

Summary

This Phase 2 trial tests IHL-42X, a combination of two drugs (dronabinol and acetazolamide), in people with obstructive sleep apnea. The study aims to see if the drug can reduce the number of breathing pauses during sleep and improve daytime symptoms. Participants will receive different doses of IHL-42X or a placebo over several four-week periods. The goal is to find a safe and effective dose that could offer an alternative to current treatments like CPAP machines.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: IHL-42X (dronabinol and acetazolamide combination)
What this could lead to: If successful, this could offer a new medication option for people with obstructive sleep apnea, potentially reducing the need for CPAP machines.
What could go wrong: This is a Phase 2 trial with a small number of participants, so results may not apply to everyone. The drug may cause side effects or prove no better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSTRUCTIVE SLEEP APNEA (OSA)

Contacts and locations

Locations

CNS Healthcare - Jacksonville
NOT_YET_RECRUITING

Jacksonville, Florida, 32256, United States
CNS Healthcare - Memphis
NOT_YET_RECRUITING

Memphis, Tennessee, 38119, United States
CNS Healthcare Orlando
NOT_YET_RECRUITING

Orlando, Florida, 32801, United States
CTI Clinical Research Center
RECRUITING

Cincinnati, Ohio, 45212, United States
Conquest Research/Neurotrials
NOT_YET_RECRUITING

Winter Park, Florida, 32789, United States
Exalt Clinical Research
NOT_YET_RECRUITING

Chula Vista, California, 91910, United States
FutureSearch Trials of Dallas
NOT_YET_RECRUITING

Dallas, Texas, 75251, United States
Intrepid Research
NOT_YET_RECRUITING

Cincinnati, Ohio, 45245, United States
Palm Beach Research Center
RECRUITING

West Palm Beach, Florida, 33409, United States
Sleep Therapy & Research Center
RECRUITING

San Antonio, Texas, 78229, United States
Tandem Clinical Research
NOT_YET_RECRUITING

Marrero, Louisiana, 70072, United States
Teradan Clinical Trials LLC
RECRUITING

Brandon, Florida, 33511, United States
Velocity Clinical Research, Anderson
RECRUITING

Anderson, South Carolina, 29621, United States
Velocity Clinical Research, Rockville
NOT_YET_RECRUITING

Rockville, Maryland, 20854, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.