Could a common drug fix sleep apnea and curb opioid cravings?

NCT ID NCT06521476

Recruiting now Symptom relief Sponsor: Sanjay R Patel Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether acetazolamide, a drug used for other types of sleep apnea, can help people on methadone or buprenorphine who develop central sleep apnea. Forty participants will take either the drug or a placebo for 7 days, then have an overnight sleep study. Researchers will also check if better sleep reduces drug cravings and anxiety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: acetazolamide
What this could lead to: If it works, this could point toward a way to treat sleep apnea in people on opioid addiction medication, possibly reducing drug cravings.
What could go wrong: This is a small, early-phase trial with only 40 participants and a short 7-day treatment. Results may not apply to everyone, and acetazolamide may cause side effects like tingling or kidney issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

central sleep apnea syndrome drug induced central sleep apnea opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CENTRAL SLEEP APNEA COMORBID WITH OPIOID USE

Contacts and locations

Locations

University of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

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