Could a natural compound in wheat germ help lower cholesterol and weight?

NCT ID NCT07662330

Recruiting now Disease control Sponsor: Shanghai 10th People's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates whether taking spermidine, a natural compound found in wheat germ, can improve blood fat levels and body weight in overweight or obese adults with high cholesterol. Participants take either spermidine capsules or a placebo daily for one month. The goal is to see if spermidine safely helps manage cholesterol and weight without medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: spermidine
What this could lead to: If it works, this could point toward a natural supplement to help manage cholesterol and weight in people with obesity and high lipids.
What could go wrong: This is a small, early trial with only 50 participants and a short 1-month duration. Results may not apply to everyone, and the supplement may cause side effects like digestive issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hyperlipidemia Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERLIPIDEMIA OBESITY & OVERWEIGHT

Contacts and locations

Locations

Shanghai Tenth People'S Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200072, China

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