HYPERLIPIDEMIA

This study investigates whether taking spermidine, a natural compound found in wheat germ, can improve blood fat levels and body weight in overweight or obese adults with high cholesterol. Participants take either spermidine capsules or a placebo daily for one month. The goal is …

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This study is testing a community-based program that uses exercise training and lifestyle changes to help people with high blood pressure, high blood sugar, or high cholesterol. The goal is to improve heart and lung function and overall disease control. The program will enroll 10…

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This phase 3 trial tests whether the experimental drug SHR-1918 can safely lower LDL cholesterol and triglycerides in 900 adults with hyperlipidemia who are already on statins. Participants are randomly assigned to receive SHR-1918 or a placebo. The study aims to see if the drug …

This study is testing a mini-program (like a smartphone app) that gives personalized exercise advice to people with high blood pressure, high blood sugar, high cholesterol, and high uric acid. Over six months, 100 participants will use the app to increase their daily steps and ph…

This early-phase study tests a new injectable drug, COR-1004, for safety and proper dosing in people with high LDL (bad) cholesterol. About 60 healthy volunteers who are not on cholesterol meds will receive a single shot of the drug or a placebo. Researchers will monitor side eff…

This study tests whether a team of healthcare professionals using a special algorithm can lower 'bad' cholesterol (LDL-C) more effectively than standard care in people with heart or blood vessel disease. About 100 adults with high cholesterol and known vascular disease will be ra…

This study tests whether rapidly adjusting cholesterol-lowering medications, based on frequent blood tests, helps heart disease patients reach their LDL cholesterol targets faster. Researchers will enroll 1000 adults with coronary artery disease and monitor their cholesterol leve…

This study tests a program called MINDSET for veterans with chronic conditions like heart disease or diabetes who smoke or drink too much. Participants receive a mailed packet with personalized health information and a brief motivational phone call. The goal is to see if this app…

This study tests a 24-week community-based lifestyle program called Inspire HER for Black women aged 30-79 with heart, kidney, or metabolic conditions. The program provides health education, physical activity, and social support to improve heart health. Researchers will also comp…

This study tests an experimental drug called HRS-1301 in people with high cholesterol (dyslipidemia). About 189 participants will receive one of four doses of HRS-1301 or a placebo daily for 12 weeks. The main goal is to see how much the drug lowers 'bad' LDL cholesterol and to f…

This study tests whether an AI-powered smartphone app, called 'Smart family doctor,' can help people who have had heart bypass surgery or stents better control their blood pressure, diabetes, and cholesterol. About 536 adults who already have these conditions will use the app to …

This study tests whether adding a structured self-management program (DECIDE) to standard community health worker support helps 500 Philadelphia residents aged 35-75 better manage heart disease risks and meet their social needs. Participants will either receive the enhanced progr…

This study is testing whether wearing a smartwatch and getting personalized health coaching through a mobile app can help people with high blood pressure, diabetes, obesity, or related conditions improve their lifestyle. About 1,700 adults aged 21-75 will wear a smartwatch for at…

This study tests whether ursodeoxycholic acid (UDCA), a drug used for bile duct problems, can stop statins from raising blood sugar. 128 adults with high cholesterol but normal blood sugar will take either UDCA or a placebo alongside atorvastatin for 6 months. Researchers will tr…

This study looks at whether different exercise programs can improve blood flow in the legs of older adults with poor circulation. About 425 participants will be split into groups doing either mixed exercise, high-intensity rowing, or vibration exercise for 12 weeks. The goal is t…

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart arteries of people with mild heart disease. Researchers will use advanced CT scans to measure changes in plaque size and type over 3 months, and then check if those changes las…

This study tests whether wearing noise-canceling earplugs can lower stress and reduce heart disease risk in people annoyed by traffic noise. Researchers will use brain and blood vessel scans to measure changes over 6 months in 26 adults with heart risk factors. The goal is to see…

This study looks at how taking multiple medications (polypharmacy) affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older over two years to understand their medicati…