Bile acid pill may shield against statin blood sugar side effect

NCT ID NCT06684106

Recruiting now Prevention Sponsor: First Affiliated Hospital Xi'an Jiaotong University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study tests whether ursodeoxycholic acid (UDCA), a drug used for bile duct problems, can stop statins from raising blood sugar. 128 adults with high cholesterol but normal blood sugar will take either UDCA or a placebo alongside atorvastatin for 6 months. Researchers will track changes in blood sugar and safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ursodeoxycholic acid (UDCA)
What this could lead to: If it works, this could offer a way to prevent statin-related blood sugar increases, making statins safer for long-term use.
What could go wrong: This is a small, early-stage trial. The effect may be modest or not appear at all, and UDCA may cause its own side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hyperlipidemia glucose intolerance prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLUCOSE INTOLERANCE HYPERLIPIDEMIA STATIN THERAPY URSODEOXYCHOLIC ACID

Contacts and locations

Locations

Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi'an, Shaanxi, 710061, China
The First Affiliated Hospital of Xi 'an Jiaotong University
RECRUITING

Xi'an, China

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