OBESITY & OVERWEIGHT

This study looks at whether group food and nutrition education, based on Brazil's dietary guidelines, can help adults with overweight or obesity eat better and lose weight. About 60 participants will attend four monthly group sessions or receive individual counseling. Researchers…

This study tests whether personalized nutrition coaching helps overweight or obese nurses at an Indonesian hospital lose weight, eat better, and be more active. Over 8 weeks, 44 nurses will receive online coaching tailored to their needs. The goal is to see if this program leads …

This study tests whether taking a daily supplement called Urolithin A (500 mg) for 6 months helps adults with obesity lose weight while keeping muscle mass and improving metabolism. About 100 adults aged 30-60 with a BMI over 30 and high belly fat will follow a structured diet an…

This study tests whether the medication lisdexamfetamine can help people who struggle with loss-of-control eating after bariatric surgery and didn't improve with earlier treatments. About 60 adults who had gastric bypass or sleeve gastrectomy will receive either the drug or a pla…

This study looks at whether a new digital weight management program, approved by NICE, can help people with obesity in NHS services. About 580 adults will use the program, and researchers will track weight changes, quality of life, and costs over 12 months. The goal is to see if …

This study tests whether a structured high-protein diet with meal replacements helps adults with overweight or obesity lose more weight than a standard low-calorie diet. About 60 participants will follow a calorie-restricted plan and attend visits for body measurements and blood …

This study tests whether behavioral therapy, a combination medication (naltrexone/bupropion), or both can help people who experience loss-of-control eating after bariatric surgery. About 160 adults who had gastric bypass or sleeve gastrectomy about six months ago will participate…

This study tests an investigational injection called GZR18 to help adults with obesity or overweight lose weight. About 630 participants in China will receive either the drug or a placebo, along with diet and exercise guidance. The main goal is to see how much weight they lose ov…

This study tests a supplement called cornfit™, made from corn silk, to see if it helps reduce body fat and manage weight. About 100 adults with a BMI between 25 and 32 will take either the supplement or a placebo for 12 weeks. Researchers will measure changes in body fat using a …

This study will offer group medical appointments for weight loss to 3,600 adults with obesity (BMI 30 or higher) at Cleveland Clinic primary care offices. The goal is to see if these shared visits help people lose weight and improve heart health. Participants will attend group se…

This study tests whether a combination medication (naltrexone/bupropion) can help people who had weight-loss surgery avoid relapsing into loss-of-control eating and regain weight. About 100 adults who responded well to an earlier treatment will receive either the medication or a …

This study tests a program to help children ages 3 to 6 in Suzhou maintain a healthy weight. It includes diet, physical activity, and education for families and schools. About 1,486 children are taking part. The goal is to see if the program lowers body fat and keeps kids at a he…

This study looks at whether a carefully controlled low-fat diet can increase reproductive hormones in women with obesity who have trouble getting pregnant. Researchers will measure hormone levels in urine before and after the diet. The goal is to see if diet alone can improve hor…

This study looks at whether 8 weeks of resistance training with blood flow restriction (using cuffs on the arms or legs) can improve muscle strength, body measurements, blood markers, and how hard exercise feels in adults with obesity. About 30 people aged 18-40 with a BMI betwee…

This study compares two types of exercise training to see which one better improves heart health and physical fitness in young adults with obesity. Forty participants will follow a 12-week program, and researchers will measure changes in weight, body fat, blood pressure, choleste…

This study uses advanced heart imaging to learn how early heart failure develops in people with diabetes, high blood pressure, or obesity. Researchers will scan the hearts of 3,000 participants and track their health over time. The goal is to improve diagnosis and risk prediction…

This study follows 14 adults who had a second weight-loss surgery because they regained weight after their first one. Researchers measure changes in weight, body fat, muscle, and blood tests before surgery and one year later. The goal is to learn how well the second surgery works…

This study looks at 49 adults who had bariatric surgery at least 5 years ago and either didn't lose enough weight or regained weight. Researchers are checking their eating habits, emotional eating, and nutrition to find patterns. The goal is to help doctors create better support …

This study follows 500 adults with obesity to learn why some people lose weight more easily than others. Participants complete surveys, blood tests, and physical measurements at their first visit to a weight loss clinic. The goal is to use this information to create personalized …

This study looks at why children and teens choose to be physically active. Researchers measured fitness, motor skills, thinking abilities, and body composition in 325 third-graders. The goal is to understand what motivates kids to stay active, which can help create better program…

This study compares two ways of connecting the intestine during a type of weight-loss surgery called SADI-S. About 82 adults will be randomly assigned to either a hand-sewn or stapled connection. The goal is to see which method leads to fewer early complications like leaks, bleed…

This study was designed to see if adding the amino acid isoleucine to a healthy, low-isoleucine diet would change how the body responds to insulin in people with obesity and prediabetes. It planned to enroll adults with a BMI of 30 or higher who also had metabolic syndrome. Howev…

This study follows 50 obese patients (BMI over 32) aged 16-60 who are having weight-loss surgery. Researchers use MRI scans and blood tests before surgery and at 1, 3, and 6 months after to measure fat in the pancreas and check how well the pancreas is working. The goal is to see…

This study looks at how GLP-1 medications (like Ozempic) affect what and how people eat. Researchers will use a special device to measure every sip of sugary and fatty drinks taken by 140 adults—some on the drug, some not. The goal is to understand exactly how these drugs reduce …

This study re-examines 317 adults with type 2 diabetes who were first checked between 2019 and 2023. Researchers use advanced scans and blood tests to see how many have fatty liver disease (MASLD) and whether it has gotten better or worse over time. The goal is to learn what fact…

This study follows 20 adults who had sleeve gastrectomy surgery about 8 years ago to see how their weight, body composition, and health markers have changed. Researchers compare current measurements to data from before surgery and 6 months after. The goal is to understand how wel…