OBESITY & OVERWEIGHT

This study is testing whether a supplement made from corn silk can help reduce body fat and support weight management. Researchers will enroll 100 overweight adults who will take either the Cornfit™ supplement or a placebo for 12 weeks while following a diet plan. The main goal i…

This study is expanding a program of group medical appointments for obesity treatment across 56 Cleveland Clinic primary care offices in Ohio. The program offers intensive lifestyle coaching in a group setting to help patients lose weight and improve health. Researchers will trac…

This early-stage study is testing a potential weight management drug called petrelintide. It aims to see if using different concentrations of the same single injection dose changes how the body absorbs and handles the drug, and if it affects safety. The study involves 48 adults w…

This study follows people who had a second weight loss surgery because they regained weight after their first one. Researchers will track their weight, body measurements, and blood test results for one year after the second surgery. The goal is to understand how this follow-up su…

This study is testing whether a behavioral weight loss program and a combination medication (naltrexone/bupropion) can help people who struggle with loss-of-control eating after bariatric surgery. It involves 160 adults who are about six months past their surgery and still experi…

This study aims to find out if high-intensity interval training (HIIT) is better than traditional moderate exercise for improving heart health and fitness in young adults with obesity. Researchers will compare the two exercise programs over 12 weeks in 40 participants. They will …

This study compares two ways surgeons connect intestines during SADI-S weight loss surgery: hand-sewn stitches versus mechanical staples. Researchers want to see which method leads to fewer leaks, complications, and shorter hospital stays for 82 patients. The goal is to find the …

This study is testing whether a daily supplement called Urolithin A can help adults with obesity lose weight while protecting their muscle mass and improving their metabolic health. All 100 participants will follow the same structured diet and sleep program, but half will receive…

This study is testing whether a medication called lisdexamfetamine can help people who continue to struggle with binge eating and weight regain after bariatric surgery. It focuses on patients who did not respond well to initial treatments. Researchers will compare the medication …

This large, late-stage study is testing whether a new injection called GZR18 helps adults with obesity or overweight lose weight. About 630 participants in China will receive either the real injection or a placebo (dummy shot) to compare results. The main goal is to see how much …

This study is testing whether 8 weeks of resistance training with blood flow restriction can improve muscle strength and health markers in adults with obesity. Researchers will work with 30 participants to see if this special exercise approach helps with strength, body measuremen…

This study is testing whether 8 weeks of personalized online nutrition coaching can help overweight and obese nurses improve their health. It involves 44 nurses at an Indonesian hospital who will receive guidance on diet and physical activity. The goal is to see if this approach …

This study is testing whether a medication called naltrexone/bupropion can help people maintain control over binge eating and keep weight off after bariatric surgery. It involves 100 adults who had surgery about 10 months ago and initially responded well to treatment for binge ea…

This study is testing a one-year program designed to help prevent obesity in preschool children. The program involves health education, dietary guidance, and increased physical activity for children, and also works with their families and schools. Researchers are measuring childr…

This study aims to understand how weight-loss surgery helps improve type 2 diabetes in obese patients. Researchers will use MRI scans and blood tests to measure fat in the pancreas and insulin function before and after surgery. The goal is to see if reducing pancreatic fat leads …

This study aims to understand what factors help people with obesity succeed at losing weight. Researchers will follow 500 adults from a weight loss clinic, collecting detailed health and lifestyle information. The goal is to use this data to build better, more personalized weight…

This study is checking back with 317 people who have type 2 diabetes to see how their liver health has changed over several years. Researchers are not testing a treatment; instead, they are using scans and blood tests to understand why some people develop serious liver disease an…

This study aims to use advanced heart scans to better understand early heart failure in people with conditions like diabetes, high blood pressure, or obesity. It will enroll 3,000 participants who have these risk factors but whose hearts still pump normally. The goal is to find p…

This university research project aims to understand what motivates children to be physically active and how activity impacts their fitness, thinking skills, and body composition. The study involves 325 third-grade students who undergo fitness tests, wear activity monitors, and co…

This study aims to understand why some people regain weight years after successful bariatric (weight loss) surgery. Researchers are looking at 49 adults who had surgery at least five years ago and have since regained weight or didn't lose enough initially. They will measure body …

This study aims to learn if following a specific low-fat diet for one month changes reproductive hormone levels in women with obesity. It involves 30 women who will track their menstrual cycles and provide urine and blood samples over about four months. The goal is to gather info…

This study follows 20 people who had sleeve gastrectomy weight loss surgery 8 years ago to see how they're doing now. Researchers will measure their weight, body composition, blood work, and nutrition to understand what factors help people keep weight off long-term. The goal is t…

Ingestion of food instigates the release of a battery of enteroendocrine peptide hormones that help control gut motility and digestive secretion. Peptide hormone products of the enteroendocrine L-cell and GLP-1 in particular, play multiple roles in relation to the regulation of p…