OBESITY & OVERWEIGHT

This study tests whether offering personalized financial incentives can help 80 adults with obesity stick to a weight-loss program. Participants attend virtual group classes, log their calories, and weigh themselves regularly. The goal is to see if tailored rewards improve diet t…

This study investigates whether tirzepatide, a drug used for diabetes and weight loss, can reverse biological aging in people with HIV who are virally suppressed and have obesity. Participants receive tirzepatide for 25 weeks after a diet program. Researchers measure epigenetic a…

This study tests whether a 12-week telephone health coaching program, called Support Your Heart, is practical and helpful for young adults aged 18-39 who have at least two heart disease risk factors (like poor sleep, inactivity, or high blood pressure). Twenty participants in the…

This study tests two experimental drugs, AZD6234 and AZD9550, given as weekly injections to Chinese adults with obesity or overweight. About 871 participants will receive the drugs alone, together, or a placebo. The main goal is to check safety and how well the drugs work for wei…

This study looks at whether adding Traditional Chinese Medicine (TCM) to standard weight-loss drugs helps people lose more weight. About 296 adults with obesity (BMI 27 or higher) in Taiwan are being followed for 6 to 12 months. Researchers are measuring weight loss, body fat, an…

This study tests whether a structured high-protein diet with meal replacements helps adults with overweight or obesity lose more weight than a standard low-calorie diet. About 60 participants will follow a calorie-restricted plan and attend visits for body measurements and blood …

This study is testing a new digital weight management program for adults with obesity who are referred to NHS Tier 3 services. The program uses a smartphone app to help people manage their weight. Researchers want to see if it improves health, saves money, and works well for pati…

This study tests whether group nutrition education based on Brazil's dietary guidelines can help overweight adults eat better and lose weight. Sixty participants will attend monthly group sessions or receive individual counseling. Researchers will compare diet quality, BMI, and w…

This study tests whether a combination of medication (naltrexone/bupropion, also known as Contrave) and behavioral weight-loss counseling can help people who experience loss-of-control eating after bariatric surgery. About 160 adults who had gastric bypass or sleeve gastrectomy a…

This study will offer shared medical appointments (group visits) for obesity treatment to over 140,000 patients across 56 Cleveland Clinic primary care practices. About 3,600 adults aged 20-75 with a BMI of 30 or higher will take part. The goal is to see if offering these group v…

This study tests whether personalized nutrition coaching, delivered online, can help overweight or obese nurses at an Indonesian hospital lose weight, eat better, and become more active. Over 8 weeks, 44 nurses will receive individual guidance to make lasting lifestyle changes. T…

This study tests whether taking Urolithin A daily for 6 months helps adults with obesity lose weight while keeping muscle mass and improving metabolism. About 100 participants aged 30-60 with a BMI over 30 will follow a structured diet and sleep program, with half receiving the s…

This study tests a supplement called Cornfit™, made from corn silk, to see if it helps reduce body fat and manage weight in adults who are overweight or obese. One hundred participants will take either Cornfit™ or a placebo for 12 weeks. Researchers will measure changes in body f…

This study tests whether the medication naltrexone/bupropion (Contrave) can help people who had bariatric surgery maintain control over eating and avoid weight regain. About 100 adults who previously responded to treatment for loss-of-control eating will receive either the medica…

This study looks at whether high-intensity interval training (HIIT) can improve heart health and physical fitness in young adults with obesity. Forty participants will do HIIT three times a week for 12 weeks. Researchers will measure changes in fitness, body composition, and bloo…

This Phase 3 study tests an injection called GZR18 for weight loss in 630 adults who are obese or overweight with related health issues. Participants receive either the drug or a placebo, and researchers measure weight change over time. The goal is to see if GZR18 is safe and eff…

This pilot study will test whether providing Mediterranean diet groceries plus virtual nutrition classes helps overweight adults at risk for type 2 diabetes improve their diet and lose weight. Forty participants in the US South will be randomly assigned to receive either weekly g…

This study tests a program for children ages 3 to 6 that includes monthly health lessons and extra physical activity at school. The goal is to see if these activities help children maintain a healthy weight. About 1,500 children in Suzhou, China, are taking part.

This study tests a program called Healthy Eating for My Infant (HEMI) designed to prevent obesity in infants from low-income families. The program includes educational sessions and peer support to help mothers with feeding and mental health. Researchers will enroll 60 mother-infa…

This study tests whether a 16-week mindfulness-based nutrition group program is feasible and acceptable for adults with obesity who are already taking GLP-1 medications. Forty participants will either join the group program plus usual care or receive usual care alone. The program…

This study looks at whether 8 weeks of resistance training with blood flow restriction can improve muscle strength, body measurements, and health markers in adults with obesity. Thirty participants aged 18 to 40 with a BMI between 30 and 40 will do leg and arm exercises using lig…

This study looks at whether a low-fat diet can increase reproductive hormones in women with obesity. Thirty women with regular cycles and no other hormone issues will follow a carefully controlled diet. The goal is to see if diet alone can improve hormone levels linked to fertili…

This trial tests whether wearable devices can measure how the body responds to everyday challenges like changes in salt intake, meals, fasting, and exercise in adults with endocrine or metabolic disorders. Participants wear home monitoring devices and follow different diet and ac…

This pilot study will compare two diets—one high in ultra-processed foods and one typical American diet—in 6 adults with overweight or obesity. Participants will try each diet for two weeks in random order. The goal is not to prove which diet is better, but to see if a larger stu…

This study directly measures how GLP-1 medications (like Ozempic) change the way people eat. Researchers use a special device to track every sip of sugary and fatty drinks in 140 adults with obesity. The goal is to understand exactly how these drugs reduce calorie intake, not jus…

This study was designed to see if adding the amino acid isoleucine to a healthy, low-isoleucine diet would change how the body responds to insulin in people with obesity and prediabetes. It planned to enroll adults with a BMI of 30 or higher who also had metabolic syndrome. The s…

This study follows 500 obese adults to see how different factors like diet, exercise, stress, and sleep affect weight loss. Researchers collect blood tests, measurements, and questionnaires at the start and during follow-up. The goal is to find patterns that could lead to more pe…

This study looks at why children and teens choose to be physically active. Researchers measured fitness, motor skills, thinking abilities, and motivation in 325 third-graders. The goal is to learn how to encourage kids to stay active for better long-term health.

This study follows 50 obese patients who are having weight-loss surgery (laparoscopic sleeve gastrectomy). Researchers use MRI scans and blood tests before surgery and at 1, 3, and 6 months after to measure changes in pancreatic fat and insulin function. The goal is to see if los…

This study looks at 49 adults who had bariatric surgery at least 5 years ago and later regained weight or didn't lose enough. Researchers want to understand how disordered eating, emotional eating, and nutrition affect weight regain. The goal is to help create better follow-up ca…

This study follows 20 people who had sleeve gastrectomy about 8 years ago to see how their weight, body measurements, and health markers have changed. Researchers compare current data with measurements taken before surgery and 6 months after. The goal is to understand long-term w…

This study follows 14 adults who had a second weight-loss surgery (conversion bariatric surgery) because they didn't lose enough weight or regained weight after their first surgery. Researchers will measure changes in weight, body fat, muscle, and blood tests over one year. The g…

This study uses advanced heart MRI scans to better understand early-stage heart failure in people with risk factors like diabetes, high blood pressure, or obesity. Researchers will follow 3,000 participants over time to see how the heart changes and who develops serious problems.…

This study compares two ways of reconnecting the intestine during a type of weight-loss surgery called SADI-S. About 82 adults aged 18-70 having this surgery will be randomly assigned to either a hand-sewn or stapled connection. The goal is to see which method leads to fewer earl…

This study follows 317 adults with type 2 diabetes who were first examined between 2019 and 2023. Researchers will repeat advanced liver scans, blood tests, and body composition measurements to see how liver fat and scarring change over time. The goal is to find out who is most a…