Can a pill keep weight off after bariatric surgery? new trial investigates
NCT ID NCT04605081
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether the medication naltrexone/bupropion (Contrave) can help people who had bariatric surgery maintain control over eating and avoid weight regain. About 100 adults who previously responded to treatment for loss-of-control eating will receive either the medication or a placebo daily. The goal is to see if the medication reduces relapse of binge-like eating and helps keep weight off longer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
naltrexone and bupropion (Contrave)
What this could lead to
If successful, this could provide a medication option to help people maintain control over eating and weight after bariatric surgery.
What could go wrong
This is a mid-stage trial with only 100 participants, so results may not apply to everyone. The medication may cause side effects like nausea or headache, and it may not prevent relapse for all.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Yale School of Medicine
New Haven, Connecticut, 06510, United States