Can a pill keep weight off after bariatric surgery? new trial investigates

NCT ID NCT04605081

Ongoing Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the medication naltrexone/bupropion (Contrave) can help people who had bariatric surgery maintain control over eating and avoid weight regain. About 100 adults who previously responded to treatment for loss-of-control eating will receive either the medication or a placebo daily. The goal is to see if the medication reduces relapse of binge-like eating and helps keep weight off longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: naltrexone and bupropion (Contrave)
What this could lead to: If successful, this could provide a medication option to help people maintain control over eating and weight after bariatric surgery.
What could go wrong: This is a mid-stage trial with only 100 participants, so results may not apply to everyone. The medication may cause side effects like nausea or headache, and it may not prevent relapse for all.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

binge eating disorder Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOSS-OF-CONTROL EATING OBESITY & OVERWEIGHT

Contacts and locations

Locations

Yale School of Medicine

New Haven, Connecticut, 06510, United States

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