Binge eating disorder

This early-stage study tests whether MDMA (the active ingredient in ecstasy) combined with talk therapy can help people with bulimia nervosa. Forty adults will be assigned to one of three groups: MDMA with general therapy, MDMA with bulimia-specific therapy, or standard treatment…

This study tests whether a non-invasive brain stimulation technique called TMS can help people with mental illness quit smoking. Forty daily smokers with psychiatric conditions will receive either TMS or standard care. The goal is to see if TMS is practical and effective in real-…

This Phase 3 trial is testing whether solriamfetol, a drug already approved for sleep disorders, can reduce binge eating episodes in adults with binge eating disorder. About 450 participants will receive either solriamfetol or a placebo daily for 12 weeks. The main goal is to see…

This phase 2 trial tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce binge-eating episodes and help with weight loss in adults with obesity and binge-eating disorder. About 105 participants will receive tirzepatide, a placebo, or the existing drug li…

This study looks at whether adding GLP-1 weight-loss drugs to cognitive behavioral therapy helps adults with severe obesity and binge eating disorder. About 80 participants will either take a GLP-1 drug or not, while both groups attend therapy sessions. Researchers will track cha…

This study is testing whether two questionnaires (SCOFF-F and EDE-Q) can accurately detect eating disorders in pregnant women, separating them from normal pregnancy-related eating concerns. Researchers will compare answers from 50 pregnant women with and without diagnosed eating …

This study tests whether adding a mobile app and digital monitoring to standard group therapy can better prevent suicide risk in women with eating disorders. Researchers will compare two groups of 150 women aged 18-65 who have recently had suicidal thoughts or attempts. One group…

This study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…

This study tests whether a text message program that helps people reduce 'safety behaviors' (like checking mirrors or seeking reassurance) can lessen appearance anxiety, body dysmorphic symptoms, and related eating or social anxiety issues. About 300 adults with high appearance c…

This study tests whether a nasal spray containing oxytocin (a natural hormone) can help adults with binge-eating disorder eat less often in binges. About 60 adults will receive either the oxytocin spray or a placebo for 8 weeks. Researchers will track changes in binge frequency a…

This study tests a mobile app designed to help adults with eating disorders stay motivated and ready for treatment while they are on a waitlist. Participants will either use the app for four weeks or continue with standard waitlist care. The goal is to see if the app can prevent …

This study tests a brief online program called COR for adults who struggle with binge eating. The program includes eight weekly sessions that teach skills to manage emotions and reconnect with eating in a healthy way. Researchers want to see if people find the program helpful and…

This study tests a virtual reality (VR) headset that uses circadian reset technology to improve sleep and reduce binge eating in 40 adults with binge eating disorder. Participants use the headset for 10 minutes twice daily for one month. Researchers will compare changes in binge …

This study is testing an AI-powered chatbot called Exp-ED that guides teens and young adults through exposure therapy exercises to reduce anxiety about weight gain. Twenty participants in a partial hospitalization program for eating disorders will use the app for six weeks. Resea…

This study is testing whether a virtual reality version of a therapy exercise is practical and helpful for adults (ages 18-65) with psychiatric disorders. Participants will try one VR session and answer questions about their experience. The goal is to see if this approach is acce…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered over video for people in New York who struggle with worry, overthinking, or being hard on themselves. The goal is to see if the therapy helps people better manage their emotions and fee…

This study tests a 6-week virtual program called the Diabetes Body Project 2, designed to prevent eating disorders in women aged 18-40 with type 2 diabetes. The program includes weekly group sessions and home exercises to improve body image and reduce disordered eating. Researche…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help people with type 1 diabetes who also have eating disorders. Participants will be randomly assigned to ACT, supportive diabetes counseling, or a waitlist. The goal is to see if …

This study looks at how well and how safely a new sleep medication, lemborexant, works for people who have both a mental health condition and trouble sleeping. About 121 adults will take the drug for 8 weeks, and researchers will track changes in their sleep quality and any side …

This study tests two smartphone-based programs for adults with binge eating disorders. One program uses heart rate feedback and breathing exercises, while the other uses guided body scans to help people connect with internal sensations like hunger. The goal is to reduce binge eat…

This study tests whether sailing can help people with psychiatric disorders feel better. Forty adults in France will either take sailing lessons or continue their usual care. Researchers will measure changes in quality of life, mental well-being, and self-esteem to see if sailing…

This study tests a mobile app called BEST-U that helps university students reduce binge eating. About 74 students with binge-eating disorder or bulimia will use the app or a comparison therapy. The goal is to see if the app makes it easier for students to get effective help witho…

This study tests a mobile app called FoodTraining that trains people to resist food cues. About 113 adults with obesity, bulimia, or binge-eating disorder will use the app for 4 weeks alongside their usual treatment. Researchers will measure changes in emotional eating and uncont…

This study compares two types of talk therapy for teenagers with eating disorders: enhanced cognitive-behavior therapy and family-based treatment. About 200 adolescents will be randomly assigned to one of the two therapies. The goal is to see if cognitive-behavior therapy works a…

This study tests whether virtual cognitive behavioral therapy (CBT) can help reduce binge eating and bulimia symptoms in veterans and other underrepresented groups. About 144 adults with binge eating disorder or bulimia will receive therapist-led or self-help CBT via telehealth. …

This study tests whether a 16-session digital program that combines mindfulness with cognitive-behavioral therapy (CBT) is acceptable and practical for adults with binge eating disorder. Forty participants will be randomly assigned to the combined program or a simpler self-monito…

This early study tests a new therapy called PRIDE for sexual minority individuals (lesbian, gay, bisexual, etc.) who have an eating disorder. The therapy aims to reduce internalized stigma and improve coping with stress related to their identity. Thirty participants will attend u…

This study tests a new way to treat eating disorders by personalizing therapy based on each person's most troubling symptoms. Researchers use smartphone surveys to map individual symptom patterns, then match participants to specific therapy modules. The goal is to see if this tai…

This study tests whether adding a peer coach or parent coach to standard eating disorder therapy helps teens aged 12-18 recover faster. 70 participants will receive 12 weeks of therapy plus either a parent coach with patient education materials or patient coaching with parent edu…

This study follows 1,500 children ages 8 to 17 over several years to learn how genes, sleep, mood, and environment affect eating behavior and overall health. Participants wear wrist monitors, answer smartphone surveys, and provide samples like blood and stool. The goal is to iden…

This study is testing a smartphone app that uses brief surveys and phone sensor data to detect when someone with an eating disorder might be at higher risk for behaviors like binge eating, restricting food, or purging. The app then delivers short video lessons on coping skills. T…

This study compares two ways to help adults with mental health issues get follow-up care. One group gets usual care after an emergency room visit, while the other uses a new system that books a psychiatrist appointment within 48 hours through their general doctor. Researchers wil…

This study looks at the mental health of 200 teenagers aged 12 to 16 who attend special educational institutes (ITEPs) in France. Researchers will use psychiatric interviews to find out how many have conditions like depression or anxiety. The goal is to better understand their ne…

This study aims to improve suicide prevention for people who move between healthcare and the criminal-legal system. Researchers will link health records, Medicaid data, and jail booking information to identify individuals at risk and coordinate care. Over 1,000 adults with past p…

This study looks at 100 adults with severe obesity to see if the type of weight-loss surgery—sleeve gastrectomy or gastric bypass—changes binge eating, depression, and anxiety differently. Participants fill out questionnaires before surgery and for 12 months after. The goal is to…

This study looks at how certain thinking patterns, called metacognitive beliefs, relate to eating disorders in teenagers. Researchers will compare 72 girls aged 12-17 who have an eating disorder with a similar group of girls without one. The goal is to understand if these thought…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This study looks at how different front-of-pack nutrition labels—warning labels versus traffic light labels—affect food choices and negative emotions in people with eating disorders. Around 246 UK adults with a current or past eating disorder will make hypothetical food choices o…

This pilot study aims to see how common Barrett's esophagus is in people with eating disorders who have been purging (vomiting or ruminating) for at least 5 years. Researchers will use a simple, non-endoscopic device called EsoGuard to collect cell samples from the esophagus. The…

This study aims to identify subgroups of people with diabetes who share similar patterns between their blood sugar levels and mental health. By using smartphone surveys and continuous glucose monitors, researchers will create 'digital twins'—virtual models that can predict how me…

This study tests whether functional MRI (fMRI) brain scans can detect changes caused by a single dose of naltrexone in adolescents aged 13-21 with eating disorders involving binge eating or purging. Participants receive both naltrexone and a placebo in random order, two weeks apa…

This study looks at whether people with obesity who also have binge eating or food addiction experience tastes differently than those without these behaviors. Researchers will measure sweet and salty taste thresholds in 300 participants and compare groups. The goal is to understa…

This study takes gut bacteria from women with eating disorders (like anorexia or bulimia) and gives them to mice to see if the mice gain or lose weight differently. The goal is to understand if an unhealthy gut microbiome can influence body weight and eating behavior. It's a basi…

This study is creating a program called START-VET to help veterans with mental illness or substance use disorders who have recently left prison. Researchers will work with 20 veterans to develop transition materials and tools. The goal is to improve quality of life and reduce cri…

This study interviews 30 competitive athletes to learn what they believe causes and triggers eating disorders in sports. Half of the participants have had an eating disorder, and half have not. The goal is to compare their experiences and gather ideas on how to better prevent the…

This pilot study is testing whether a simple saliva test can help doctors prescribe mental health medications more safely and effectively. 200 adults in Manitoba who are starting or changing psychiatric drugs will provide a DNA sample. The results will be shared with their doctor…

This study looks at whether training psychiatric care teams to talk about sexual health with young patients (ages 15 and up) increases those conversations. Researchers will survey 770 teens hospitalized for psychiatric disorders about their sexual health and any side effects from…