New combo treatment targets Post-Surgery binge eating
NCT ID NCT04599478
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a combination of medication (naltrexone/bupropion, also known as Contrave) and behavioral weight-loss counseling can help people who experience loss-of-control eating after bariatric surgery. About 160 adults who had gastric bypass or sleeve gastrectomy about six months ago will receive either the medication, counseling, both, or a placebo. The goal is to reduce binge-eating episodes and improve weight loss.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Naltrexone and Bupropion (Contrave) pills
What this could lead to
If successful, this could provide an effective treatment option for people who struggle with loss-of-control eating after bariatric surgery, helping them achieve better weight loss.
What could go wrong
This is an early-stage study (Phase 2/3) with only 160 participants, so results may not apply to everyone. The medication can cause side effects like nausea, headache, and insomnia.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Yale Department of Psychiatry
New Haven, Connecticut, 06510, United States