OBESITY; OVERWEIGHT

This study reviews medical records of 500 adults with obesity or overweight to see if a combination of two affordable drugs, sibutramine and topiramate, helps with weight loss in real-world clinics. Participants must have taken the drugs for at least 3 months. The goal is to meas…

This study will follow 3000 people in France with severe obesity who are taking the weight-loss drug semaglutide (Wegovy). Researchers want to see how much weight people lose, who keeps taking the drug, and what factors predict success. The goal is to understand how well the trea…

This pilot study tests whether home-based high-intensity interval training (HIIT) can help people who have reversed their type 2 diabetes keep it from returning. Researchers will recruit 20 adults who completed the NHS Path to Remission programme and achieved diabetes remission. …

This study looks at whether playing active video games can help children, teenagers, and young adults (ages 5-21) with obesity and type 2 diabetes lose weight and improve their blood sugar levels. Participants will play active video games at home, and researchers will track chang…

This study tests a custom mouthpiece called Fuzzle that you wear during the day to help with weight loss. About 78 adults with obesity will use the device along with diet and behavior advice, and their weight loss will be compared to those who only get advice. The goal is to see …

This study looks at whether adding the Nutu™ digital health platform to standard weight-loss care helps people lose more weight and improve heart health. About 300 adults in a primary care program will be randomly offered the app or usual care alone. The main goal is to see if th…

This study looks at whether teaching healthy habits like exercise, better nutrition, and stress management can improve health in 120 adults who are overweight, inactive, or have metabolic syndrome. Participants will take part in programs and be followed for 12 months to see if th…

This study tests tirzepatide (Munjaro), a drug already used for weight loss and diabetes, in 30 obese adults with congenital heart disease. Over 6 months, researchers will measure changes in exercise ability, heart function, and cholesterol. The goal is to see if this drug can im…

This early-stage study tests a new drug called SGB-7342 in 45 adults who are overweight or have obesity. The main goal is to check if the drug is safe and tolerable when given as a single injection under the skin. Researchers will also measure how the drug moves in the body and h…

This study tests a supplement called Redefine in 80 overweight adults who are already taking a weight-loss drug (semaglutide) and following a low-calorie diet. The goal is to see if Redefine is safe and helps preserve muscle mass while losing weight. Participants will take Redefi…

This study compares two blood-thinning injections, tinzaparin and enoxaparin, to see which better prevents dangerous blood clots after weight loss surgery. About 180 adults having laparoscopic sleeve gastrectomy or gastric bypass will be randomly assigned to one of the two drugs.…

This study gives children with high blood pressure, high cholesterol, or obesity a free debit card to buy fruits and vegetables, plus virtual nutrition classes. Researchers want to see if this program helps kids eat more produce and improves their heart health over 6 to 12 months…

This study looks at whether adding regular exercise to the weight-loss medication tirzepatide helps people lose more weight and body fat than the medication alone. Researchers will also check if exercise improves blood sugar, cholesterol, fitness, and quality of life. The study w…

This study looks at whether adding whole-body electrical muscle stimulation to a low-calorie diet can help people with obesity lose weight and control their appetite better than diet alone. Forty adults will be split into two groups for 8 weeks. Researchers will measure changes i…

This study looks at whether a 12-week program of exercise and personalized diet advice can help prevent muscle loss in obese adults who are taking GLP-1 medications (like semaglutide) for weight loss. The researchers will measure changes in muscle mass, strength, and fitness in 2…

This study looks at whether tirzepatide, a drug used for weight loss, can help reduce the amount of time people with atrial fibrillation (an irregular heartbeat) spend in that rhythm after a procedure called catheter ablation. The trial will include 200 overweight or obese adults…

This study looks at whether adding a structured exercise and nutrition program to standard weight-loss medication helps adults with obesity keep their muscle and stay physically strong. About 120 people aged 18-70 will either get medication alone or medication plus a six-month li…

This study looks at a program to help women with severe obesity (BMI 40 or higher) and early-stage endometrial cancer get healthier before surgery. The program includes weight-loss medication, a hormone-releasing IUD, diet changes, and exercise. The goal is to see if this approac…

This study tests a program called PINPOINT that helps women with diabetes or obesity get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests whether providing healthy food and cooking lessons can help adults with high blood pressure and obesity lower their blood pressure and weight. About 150 adults will either receive the food and lessons or continue their usual care for 24 weeks. The goal is to see …

This study tests whether taking semaglutide (Wegovy) before a standard heart procedure for atrial fibrillation (AF) can help prevent the abnormal heart rhythm from coming back. About 200 overweight or obese adults scheduled for their first AF ablation will either receive semaglut…

This study looks at whether using a mobile wellness app alone or together with a wearable fitness tracker helps adults with overweight (BMI 25 or higher) lose weight and become more active. About 300 people will be split into three groups: app plus tracker, app only, or standard …

This study tests an experimental oral drug called ERX1000 in 80 adults with obesity (BMI 30-50). Participants will take the drug or a placebo daily for 24 weeks to see if it helps with weight loss and is safe. The goal is to find a new treatment option for obesity.

This study tests a 10-week behavioral program to help people maintain weight loss after stopping GLP-1 or other anti-obesity medications. 64 adults who lost at least 15% of their body weight on these drugs will be followed for 6 months. The program includes meal plans, gym member…

This study looks at whether a 4-month Zumba program can improve heart health, hormone levels, and body measurements in overweight and obese women. About 73 women, both before and after menopause, will be randomly assigned to either take Zumba classes or continue their normal rout…

This study tests a program that combines AI-guided exercise with continuous glucose monitoring for people who have both knee osteoarthritis and obesity. The goal is to see if it improves blood sugar control, reduces pain, and lowers the need for knee replacement surgery. About 31…

This study tests different combinations of diet, extra protein, and resistance exercise to help 250 adults aged 50-75 with obesity lose weight while keeping muscle. Participants will follow a personalized plan over 52 weeks. The goal is to find the best approach for healthy weigh…

This study will test if a 1-3 minute facial scan using artificial intelligence can accurately measure health indicators like heart rate, blood pressure, and blood sugar. 1,000 adults in urban areas will have their scan results compared to standard medical tests. The goal is to de…

This study tests a program called Healthy Eating for My Infant (HEMI) designed to prevent obesity in babies from low-income families. The program addresses unique challenges like maternal mental health and food insecurity through home visits. Researchers will enroll 60 mothers an…

This pilot study tests whether providing Mediterranean diet groceries along with virtual nutrition classes helps adults at risk for type 2 diabetes improve their eating habits and lose weight. Forty overweight adults from the US South will be randomly assigned to receive either w…

This study looks at whether providing free center-based childcare during the summer can prevent unhealthy weight gain in preschoolers from low-income families. Researchers will enroll 300 children who already attend a needs-based pre-K program during the school year. The goal is …

This study tests whether two types of fish oil, EPA and DHA, can improve metabolic health in people with obesity who are at high risk for type 2 diabetes. Over 12 weeks, 84 participants will take daily capsules of EPA, DHA, or a placebo (corn oil) and undergo specialized tests to…

This study tests if an experimental drug called BIO101 can help prevent muscle weakness in people taking the weight-loss drug semaglutide. About 164 overweight or obese adults will take either BIO101 or a placebo pill twice daily for 21 weeks, along with semaglutide and a reduced…

This study looks at whether adding a digital app to cognitive-behavioral therapy (CBT) helps teens aged 12-17 who have both depression and overweight or obesity. Sixty teens will be randomly assigned to either CBT alone or CBT plus the app. The goal is to see if the app makes the…

This early study tests a small implant placed under the skin that releases semaglutide (the drug in Wegovy) over 4 weeks. It compares the implant to weekly injections in 20 healthy overweight or obese adults. The goal is to see if the implant is safe and how it affects drug level…

This study tests two 2-month programs to help 60 adults with overweight or obesity eat fewer ultra-processed foods. One program uses standard diet tips, the other uses cognitive dissonance—getting people to take action against the food industry. Participants attend weekly virtual…

This study tests a new approach called 'exercise snacking' for adults aged 65 and older who are overweight. Instead of one long workout, participants do several short, 2-5 minute activity bursts throughout the day. The goal is to see if this easier routine helps improve strength,…

This early-stage study tests whether a new drug called DWRX5003 is safe in healthy adults aged 19 to 65. It also measures how the drug moves through the body compared to two other versions. The goal is to gather safety and processing data, not to treat any disease.

This study will check if common weight loss medications (semaglutide or tirzepatide), combined with diet and exercise coaching, can slow or reverse biological aging in adults aged 40 to 89 who are overweight or obese. Researchers will use a special blood test called the LinAge2 c…

This study looks at how a special type of exercise called hybrid high-intensity interval training (HIIT) affects muscle cells in 30 overweight or obese adults over time. Researchers will measure changes in mitochondria (the energy powerhouses of cells), muscle size, and fitness l…

This study compares two types of front-of-package labels to see which one better helps Indonesian adults spot and avoid foods high in sugar, salt, or fat. About 1,000 participants will view different labels and answer survey questions. The goal is to find the most effective label…

This study is testing a smartphone app called NutriTrack that uses artificial intelligence to help people with obesity or overweight track what they eat and their eating behaviors. About 20 to 50 adults will use the app for 4 weeks alongside their regular clinic visits. The main …

This study looks at whether certain autoantibodies (proteins that attack the body's own cells) are present in people with obesity and if they are linked to how severe the obesity is. Researchers will also check if these antibodies are connected to obesity-related health problems …

This study looks at how posture habits and body awareness relate to physical performance in women with different body mass indexes (BMI). Researchers will group 80 women by BMI (normal weight, overweight, and obese) and use questionnaires and physical tests to measure posture, bo…

This study looks at how much energy obese teenagers burn after eating, called dietary thermogenesis, and whether losing weight improves it. Researchers will compare 30 obese teens before and after weight loss to normal-weight teens. The goal is to understand if a lower post-meal …

This study will screen up to 10,000 adults who are overweight or have metabolic issues like high blood pressure or diabetes to find out how common fatty liver disease (MASLD) is and what factors contribute to it. Participants will fill out health questionnaires, have body measure…

This pilot study looks at how eating ultra-processed foods compares to a typical American diet in overweight or obese adults. Six participants will try both diets for two weeks each. The goal is to see if this type of study is possible and to gather data for larger future trials.

This study follows 165 mothers and their babies for 6 months after birth to see if a mother's weight and diet affect her breastmilk and her baby's growth. Researchers will measure mom's body fat, diet, and health markers, and analyze breastmilk composition. They will also track t…

This online study with 2,800 Hong Kong adults tests whether front-of-package warning labels about added sugar reduce people's intention to buy sugary drinks. Participants will choose beverages in a simulated shopping task. The goal is to see if simple labels can nudge consumers t…

This study explores whether daytime fasting during Ramadan, alone or with moderate aerobic exercise, can help overweight adults lose body fat and improve heart health. About 30 participants will be randomly assigned to fasting only or fasting plus supervised exercise. Measurement…