OBESITY & OVERWEIGHT

This trial tests whether gummies containing polydextrose, a type of dietary fiber, can help adults with overweight or obesity lose weight. Participants will take the gummies before meals for 24 weeks, alongside standard diet and exercise advice. The study compares weight loss, ap…

This phase 2 trial is testing whether adding an experimental oral drug called LUM-201 to the weight-loss medication semaglutide can improve physical function in older adults with obesity. The study enrolls people aged 60 to 85 with a body mass index (BMI) between 30 and 45 who ha…

This trial tests whether taking a GLP-1 medication (semaglutide) for at least six months before hip or knee replacement surgery can improve recovery and reduce complications in patients with obesity. Participants will be randomly assigned to receive either the medication plus beh…

This study tests whether eating one avocado daily for 12 weeks can improve blood flow to the brain and support heart and blood vessel health in adults with prediabetes and overweight or obesity. Researchers will measure brain blood flow using MRI, along with markers of blood vess…

This pilot trial tests whether tirzepatide, a once-weekly injection used for diabetes and weight loss, can improve lung function and muscle health in overweight adults with COPD. About 30 participants will receive either tirzepatide or standard care for 12 months, with tests meas…

This trial tests whether tirzepatide, a weekly injection used for diabetes and weight loss, can improve physical function in adults with heart failure and obesity. Participants will receive either tirzepatide or a placebo for six months, while continuing their usual heart failure…

This study tests different weight-loss strategies for adults aged 50 to 75 with obesity. Participants will follow either a high-protein or standard-protein diet for 16 weeks. Those who don't respond well may then receive extra protein supplements or resistance exercise training. …

This trial tests whether converting a prior sleeve gastrectomy to a procedure called intestinal transit bipartition can improve stomach emptying, reduce acid reflux, and help with weight control. Forty adults who had sleeve gastrectomy and now have weight regain or reflux will un…

This study investigates whether eating two servings of Greek yogurt daily—either whole milk or skimmed—can improve muscle protein synthesis, blood sugar control, and thinking skills in post-menopausal women who are overweight or have obesity. Participants will follow a standardiz…

This trial tests whether a simple saliva test, called MyPhenome, can guide doctors in choosing the most effective anti-obesity medication for each individual. The test sorts people into biological subtypes—like 'hungry brain' or 'hungry gut'—to personalize treatment. About 424 ad…

This trial tests whether adding tirzepatide (Mounjaro) to a structured lifestyle program reduces the return of atrial fibrillation within a year after catheter ablation in obese patients. About 710 participants with symptomatic AF and a BMI of 28 or higher (or 24 with other risk …

This study tests four nutrition programs—meal kits, ready-to-eat meals, cooking classes, and motivational texts—in 400 adults with overweight or obesity who use food pantries. The goal is to see which approach best improves diet quality and food security, with the aim of reducing…

This study looks at whether taking macaúba oil supplements while doing outdoor exercise can improve how the body burns fat and handles mental stress. Researchers will enroll 60 physically active adults aged 35 to 59 who are overweight but not obese. Participants will take either …

This study tests whether giving teens with obesity and prediabetes a continuous glucose monitor (CGM) — along with nutritional counseling — helps them eat better and keep blood sugar in check. For three months, participants see their glucose levels in real time and learn how diff…

This trial tests whether two specific diet plans can help people with obesity or overweight maintain weight loss after stopping semaglutide (Wegovy). Many patients regain weight quickly when they stop the drug. The study compares a special dietary pattern called NutriAct plus wit…

This trial tests whether changing the order of exercise (aerobic before anaerobic, or vice versa) and the order of eating (vegetables and protein first, carbohydrates last) helps overweight children and teens lose weight and improve health. Over 28 days at a weight loss camp, par…

This trial compares adapted taekwondo training with conventional exercise (moderate continuous training and stretching) in women aged 60–65 with abdominal obesity. The goal is to see which approach better reduces belly fat and improves physical function, strength, balance, and fl…

This study tests whether a daily 4-gram dose of ajwa seed powder, made from date seeds, can improve blood sugar control (HbA1c) and body composition in overweight and obese adults aged 30–50 with type 2 diabetes. Over 12 weeks, researchers will measure changes in HbA1c, weight, w…

This study tests whether the drug lumateperone can improve mood and reduce inflammation in adults with bipolar depression who also have obesity. Over about six weeks, participants take lumateperone daily and undergo mood assessments and an MRI to estimate brain age. The goal is t…

This pilot study tests a 12-week digital lifestyle program created specifically for gay men and lesbian women with obesity. Participants receive an online, self-paced intervention and provide feedback on how well it meets their needs. The goal is to see if a tailored approach imp…

This study evaluates the safety and effectiveness of the Allurion Gastric Balloon System, a swallowable balloon placed in the stomach to help with weight loss. It involves 250 adults aged 22–65 with a BMI between 30 and 40. The balloon is swallowed and later passes naturally, avo…

This study looks at whether playing active video games can help children and young adults (ages 5-21) with obesity and type 2 diabetes lose weight and lower their blood sugar levels. Participants will play active video games at home, and researchers will track changes in weight a…

This early-stage study tests a small implant placed under the skin that releases semaglutide (the drug in Wegovy) over 4 weeks. It involves 20 otherwise healthy overweight or obese adults. The goal is to see if the implant is safe and how it compares to weekly injections.

This pilot study tests whether a 10-week behavioral program can help people maintain weight loss after stopping GLP-1 or other anti-obesity medications. The program includes medically tailored meals, a YMCA membership, and a meditation component. Researchers will follow 64 partic…

This study looks at whether adding the Nutu digital health platform to a standard weight loss program helps people with obesity lose more weight and improve heart health. About 300 adults in the FLOW program will be offered Nutu, which includes AI coaching and tracking tools. The…

This study will test whether replacing breakfast and a snack with a diabetes-specific nutritional drink (Glucerna) helps people with type 2 diabetes and obesity keep their blood sugar in a healthy range more often. About 198 adults will be randomly assigned to either the drink-ba…

This pilot study will test whether supplements made from bilberries and olives can reduce inflammation and oxidative stress in people with prediabetes who are overweight. Researchers will collect blood, urine, and stool samples from 60 participants to measure changes in key healt…

This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and d…

This phase 3 study tests whether a weekly injection called UBT251 can help overweight or obese adults lose weight. Participants receive either the drug or a placebo for 52 weeks. The main goal is to measure the percentage change in body weight, with additional checks on waist siz…

This trial tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce the return of atrial fibrillation (AFib) after a heart procedure called catheter ablation. Overweight or obese adults with persistent AFib will receive either tirzepatide injections plus st…

This study tests whether a 28- to 54-week program of weight-loss medication (semaglutide), a hormone-releasing IUD, diet, and exercise is safe and feasible before surgery in women with early endometrial cancer and a BMI of 40 or higher. Eighty participants will be randomly assign…

This European trial tests a 24-week lifestyle program for 400 night-shift workers. The program, delivered via a mobile app and workshops, focuses on sleep, stress, diet, and exercise. The goal is to see if it helps workers sleep longer and improve their health.

This study tests a new drug called bofanglutide (GZR18) against the existing drug semaglutide for weight loss in 352 Latin American adults with overweight or obesity. Participants receive injections every two weeks (bofanglutide) or weekly (semaglutide) for 36 weeks, along with d…

This study tests whether taking inulin, a type of dietary fiber, can improve cholesterol and other heart-related risk factors in 600 overweight or obese adults who are already using GLP-1 medications (like semaglutide) for weight loss. Participants will take either 10 grams of in…

This study reviews medical records of 500 adults with obesity or overweight who took a combination of sibutramine and topiramate for at least three months. The goal is to see how much weight they lost and if the treatment was safe and tolerable. This is a low-cost option that may…

This study compares two blood-thinning injections (tinzaparin and enoxaparin) to prevent dangerous blood clots after weight loss surgery. About 180 adults having laparoscopic sleeve gastrectomy or gastric bypass will be randomly assigned to one of the two drugs for 21 days after …

This study looks at whether combining GLP-1 medications (like semaglutide and tirzepatide) with Noom's app-based behavioral program helps people lose weight and improve heart health markers. Over 2,300 adults will be followed for 24 months, tracking weight, blood sugar, cholester…

This study will test whether adding whole-body electrical muscle stimulation (EMS) to a reduced-calorie diet helps people with obesity lose weight and improve metabolic health. Forty adults will be randomly assigned to either diet alone or diet plus EMS for 8 weeks. Researchers w…

This study looks at whether adding exercise to the weight-loss medication tirzepatide helps people lose more weight and improve health markers like blood sugar and cholesterol. Researchers will enroll 24 adults aged 30–65 with overweight or obesity. Participants will take tirzepa…

This pilot study tests whether a home-based high-intensity interval training (HIIT) program can help people who have reversed their type 2 diabetes keep it from returning. Twenty adults who completed the NHS Path to Remission programme will either do HIIT three times a week or co…

This study tests whether a 12-week program of exercise and personalized diet counseling can help preserve muscle mass in obese adults taking GLP-1 medications like Wegovy. Twenty participants aged 40-55 will be followed to see if these lifestyle changes prevent the muscle loss of…

This study will give 150 children and teens with high blood pressure, high cholesterol, or obesity a free debit card to buy fruits and vegetables, plus virtual nutrition classes. The goal is to see if this program helps improve their heart health over 6 to 12 months. Participants…

This study tests a custom mouthpiece called Fuzzle that you wear during the day to help with weight loss. About 78 adults with obesity will use the device plus get diet advice, and their weight loss will be compared to those who only get advice. The goal is to see if the device h…

This study looks at whether using a mobile wellness app alone or with a wearable fitness tracker helps adults with overweight (BMI 25 or higher) manage their weight and get more active. About 300 people will be split into three groups: app plus tracker, app only, or standard heal…

This study tests a nutritional supplement called Redefine in 80 overweight adults who are already taking a weight-loss medication (semaglutide) and following a low-calorie diet. The goal is to see if Redefine is safe and helps preserve muscle mass while losing fat. Participants t…

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

This study tests the drug tirzepatide (Munjaro) in 30 obese adults with congenital heart disease. Over 6 months, half get the drug and half get a placebo. Researchers will check if it improves exercise ability, heart function, and cholesterol. It is one of the first studies to lo…

This early-stage study tests a single dose of an investigational drug called SGB-7342 in 45 adults who have obesity or are overweight. The main goal is to check if the drug is safe and tolerable. Researchers will also measure how the drug moves in the body and any weight changes.…

This study will test whether a 4-month Zumba program can improve heart health, hormone levels, and body composition in overweight and obese women, both before and after menopause. About 73 women will be randomly assigned to either Zumba classes or no exercise. Researchers will me…

This study tests two 2-month programs to help adults with overweight or obesity cut down on ultra-processed foods. One program uses standard diet tips like meal planning, while the other uses a 'dissonance' approach where participants take part in activism against the food indust…

This study investigates whether specific proteins found in tiny particles in the blood (called small extracellular vesicles) can help identify obese individuals who are at risk for developing type 2 diabetes. Researchers will measure levels of two proteins, integrin-β2 and ECM1, …

This study tests whether two types of fish oil, EPA and DHA, can improve metabolic health in people at high risk for type 2 diabetes. Over 12 weeks, 84 participants will take daily capsules of EPA, DHA, or a placebo (corn oil) and undergo specialized tests to measure insulin func…

This trial tests whether two non-drug programs—targeted physiotherapy or supervised exercise—can reduce bladder and bowel symptoms in adolescents aged 13–18 with obesity. Participants will be randomly assigned to one of the two interventions or to standard obesity care for 12 wee…

This trial compares using a lower gas pressure (8 mmHg) with the AirSeal device versus standard pressure (15 mmHg) during robotic weight-loss surgery. The goal is to see if lower pressure helps patients feel less pain and leave the recovery room sooner. Adults aged 18 and older h…

This study tests whether a 16-week online mindfulness-based nutrition program is feasible and acceptable for adults with obesity who are taking GLP-1 receptor agonist medications. Participants in the intervention group attend nine live video sessions on mindful eating, practice d…

This study tests whether a 6-month digital education program—with short videos on exercise, healthy eating, and stress management—can improve exercise capacity and quality of life in adults with heart failure and overweight or obesity. Fifty-two participants will be randomly assi…

This study compares two ways to align the knee during total knee replacement in 80 obese adults (BMI 35+). One method uses robotic or computer assistance, the other uses traditional manual tools. The goal is to see which leads to better knee motion and recovery after surgery.

This pilot study will test whether adding a digital app to group cognitive-behavioral therapy (CBT) helps teens aged 12-17 who have both depression and overweight. Sixty participants will be randomly assigned to either CBT plus the app or CBT alone. The main goal is to see if the…

This study looks at whether whole body vibration can improve muscle function, physical fitness, and breathing in people who have had bariatric surgery. Sixty adults who had surgery at least 6 weeks ago will be split into three groups: one does vibration exercises, one does resist…

This study tests whether a daily lutein supplement made from microalgae can slow cognitive decline in postmenopausal women with obesity. 300 women aged 48-60 will take either 6 mg, 14 mg, or a placebo for 180 days. Researchers will measure changes in memory, attention, and inflam…

This study tests a new approach called 'snack exercise' for adults aged 65 and older who are overweight. Instead of one long workout, participants do several short bursts of activity throughout the day. The goal is to see if this easier routine helps improve health, fitness, and …

This study tests if an experimental drug called BIO101 can help prevent muscle weakness in people taking the weight-loss drug semaglutide. About 164 obese or overweight adults will take either BIO101 or a placebo pill twice daily for 21 weeks, along with semaglutide and a reduced…

This study looks at how beta-cells (which make insulin) respond to growth hormone in people with prediabetes. Researchers will measure insulin release in 10 adults with impaired fasting glucose or impaired glucose tolerance. The goal is to better understand what raises the risk o…

This study looks at how two common medications, rosuvastatin (a cholesterol drug) and losartan (a blood pressure drug), are absorbed in people who have had weight-loss surgery. Sixty adults scheduled for either Roux-en-Y gastric bypass or sleeve gastrectomy will take a single dos…

This study explores whether increasing calorie intake after weight loss can restore normal appetite control. Adults with obesity will follow a 20-week diet and exercise plan, then some will have their calories adjusted upward. The goal is to see if this reduces hunger and helps w…

This study compares two types of food labels to see which one better helps Indonesian adults spot unhealthy products. Researchers will show 1,000 participants either a nutrient warning label or the Nutri-Level label and test their ability to identify foods high in sugar, salt, or…

This study tracks sleep quality in adults with obesity before and one year after metabolic surgery (gastric bypass or sleeve gastrectomy). Participants wear two sleep-monitoring devices for five nights at home and fill out sleep questionnaires and diaries. The goal is to see whet…

This study will follow 440 adults aged 40-89 who are starting a weight management program that includes drugs like semaglutide or tirzepatide along with lifestyle coaching. Researchers will measure changes in biological age using a blood-based aging clock over 6 months. The goal …

This study will test whether smelling a pleasant food odor (madeleine scent) before drinking a sugary solution changes how the body handles blood sugar. Twenty adults, some with obesity and mild insulin resistance and some without, will each undergo two sessions: one with the sce…

This study looks at whether a measurement called Body Roundness Index (BRI), which uses waist size and height, can predict death in adult intensive care unit (ICU) patients. Researchers will measure BRI in 550 adults when they enter the ICU and track their outcomes, including dea…

This study looks at whether simple physical tests like stair climbing, walking, and standing up from a chair are reliable and accurate for people with obesity. Researchers will test 55 adults with a BMI of 30 or higher, repeating the tests a week apart to check consistency. The g…

This study tests a smartphone app called NutriTrack that uses artificial intelligence to help people with obesity or overweight track what they eat and how they feel. About 50 adults will use the app for 4 weeks. The main goal is to see if the app is easy to use and helpful for b…

This study will follow 3,000 French patients with severe or complicated obesity who are taking semaglutide (Wegovy) as part of an early access program. Researchers will track weight changes, treatment patterns, and well-being over time using questionnaires. The goal is to underst…

This online study with 2,800 Hong Kong adults tests whether front-of-package warning labels about added sugar reduce people's intention to buy sugary drinks. Participants will choose a beverage in a simulated shopping task. The goal is to see if simple labels can guide healthier …

This study looks at whether certain autoantibodies (proteins that mistakenly attack the body) are more common in people with obesity and if they are linked to related health problems like type 2 diabetes. Researchers will study 160 adults with a BMI over 30. The goal is to better…

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This observational study will examine how posture habits and body awareness relate to physical function in 80 women aged 18-65 across different BMI categories (normal weight to obesity). Participants will fill out questionnaires and perform simple movement tests. The goal is to u…

This study will follow 150 mothers and their babies for 6 months to see how a mother's weight and diet affect her breastmilk and her baby's growth. Researchers will measure mom's body fat, diet, and health markers, and analyze breastmilk for nutrients and immune factors. The goal…

This study looks at how weight loss affects the energy the body uses to digest food (called dietary thermogenesis) in teens with obesity. Researchers will compare 30 obese adolescents before and after weight loss with normal-weight teens. The goal is to understand if losing weigh…

This study will screen up to 10,000 adults aged 18-75 who are overweight or have metabolic issues like high blood sugar or cholesterol. Researchers will use questionnaires, blood tests, and liver ultrasounds to find out how common fatty liver disease is and what factors increase …