OBESITY & OVERWEIGHT

This study aims to see if adding back a specific protein building block (isoleucine) to a healthy, low-isoleucine diet changes how well the body uses insulin in people with obesity and prediabetes. Researchers will enroll 40 adults with obesity and metabolic syndrome. Participant…

This study aims to see if combining Ramadan daytime fasting with a supervised aerobic exercise program leads to better improvements in body fat, blood sugar, and cholesterol levels compared to fasting alone. Researchers will enroll 30 overweight or obese adults who plan to fast f…

This early-stage study is testing a small, under-the-skin implant that slowly releases the weight-management medication semaglutide. It will compare the safety and drug levels of this single 4-week implant against four weekly injections of the same drug. The goal is to see if the…

This study is observing a pre-surgery program designed for obese women with early-stage endometrial cancer or pre-cancer. The program combines weight-loss medication, a hormone-releasing device, diet, and exercise. Researchers want to see if this approach improves patients' overa…

This study is testing if using a weight loss medication before a heart procedure can lead to better long-term results. It focuses on overweight adults with atrial fibrillation (a common irregular heartbeat) who are scheduled for their first procedure to correct it. Half the parti…

This study is testing a nutritional supplement called Redefine to see if it is safe and can help people keep their muscle while they lose weight. The trial will involve 80 adults who are already taking a prescription weight-loss medication (semaglutide) and are on a reduced-calor…

This study aims to find the most effective way to give weekly feedback to people in a weight loss program. About 127 adults with obesity or overweight will track their diet, activity, and weight, and receive weekly messages from a coach. Researchers will test if the tone and cont…

This study aims to find the best personalized approach to help adults aged 50-75 with obesity lose weight while keeping their muscle. Researchers will test different diet plans (high vs. standard protein) and add extra support like protein shakes or guided exercise if someone isn…

This study is testing a new program that combines AI-guided community exercise with continuous glucose monitoring for adults who have both knee osteoarthritis and obesity. The main goal is to see if this approach helps control blood sugar levels. Researchers will also track chang…

This study is testing whether adding a digital health app called Nutu™ to a standard primary care weight management program helps people lose more weight. It will involve 300 people already enrolled in a year-long behavioral program for obesity. Researchers will compare weight ch…

This study is testing whether short bursts of activity spread throughout the day—called 'exercise snacks'—can help overweight adults aged 65 and older improve their health. Instead of one long workout, participants try several brief activity sessions that may be easier to fit int…

This study is testing whether a 4-month Zumba dance exercise program can improve health in overweight women, both before and after menopause. Researchers will compare women who do Zumba four times a week to a group that does not exercise. They will measure changes in weight, body…

This study aims to see if a structured 12-week program can help people build healthier long-term habits. It will enroll 120 overweight, inactive adults to test a combination of supervised exercise, Mediterranean diet education, and stress-resilience workshops. Researchers will tr…

This study is testing two different 2-month programs to help 60 adults with overweight or obesity reduce their intake of ultra-processed 'junk' foods. One program uses standard diet change tips, while the other tries a new approach: teaching people about the harms of the food ind…

This is the first human study testing a new injection called SGB-7342 for weight management. Researchers will give single doses to 45 adults with obesity or overweight to check if it's safe and how the body processes it. The study will also track early signs of weight changes to …

This study aims to see if combining regular exercise with a weight loss medication (tirzepatide) works better for weight loss and improving health than taking the medication alone. It will involve 24 adults aged 30-65 who have overweight or obesity. Participants will take the med…

This study aims to see if eating peanuts daily for 12 weeks helps people who are already taking prescription weight-loss medications like Ozempic or Mounjaro. Researchers want to find out if adding peanuts improves feelings of fullness, energy levels, mood, and overall diet quali…

This study aims to see if adding a structured exercise and nutrition program to a new weight-loss medication helps people with obesity keep more muscle and stay stronger, compared to just taking the medication alone. It will involve 120 adults and last one year. The goal is to fi…

This study aims to find out if using a weight loss app together with a wearable fitness tracker is more effective for managing weight than using the app by itself. Researchers will enroll 300 adults who are overweight or have obesity and assign them to use either the app alone, t…

This study aims to see if adding a new oral medication called enobosarm to the injectable weight loss drug semaglutide helps people lose more weight than semaglutide alone. It will enroll 200 adults aged 65 and older with obesity. The main goal is to measure total body weight cha…

This study is testing if a medication called tirzepatide, which is approved for weight loss, can improve heart function and metabolic health in obese adults who were born with heart defects. About 30 participants will receive either the drug or a placebo for 24 weeks to see if it…

This study is testing whether a 'food is medicine' program can help adults with high blood pressure and obesity. For 24 weeks, half the participants will receive weekly deliveries of heart-healthy meals and cooking lessons, while the other half receives usual care. Researchers wa…

This study is testing if a medication called tirzepatide, which helps with weight loss, can also help control a persistent irregular heartbeat (atrial fibrillation) after a corrective heart procedure. It will involve 200 overweight adults who are scheduled for this procedure. Res…

This study is testing if wearing a continuous glucose monitor (CGM) can help people with prediabetes and obesity change their lifestyle to prevent type 2 diabetes. It will compare whether seeing real-time glucose data on the monitor helps people eat better and be more active comp…

This study is testing a new support program called PINPOINT to help women with diabetes or obesity get screened for cervical cancer. It will work with 20 women who are overdue for screening to see if the program is practical and well-liked. Participants will either receive the ne…

This study is testing a new program called HEMI, designed to prevent obesity in babies from low-income families. It will be delivered through home visits and focuses on supporting mothers' mental health and providing realistic feeding guidance. Researchers will check if the progr…

This study aims to see if a special breathing muscle training program can help improve lung function and reduce body-wide inflammation in people living with obesity. Researchers will enroll 40 adults with obesity to test this non-drug approach. They will measure breathing strengt…

This study is testing whether a drug called BIO101 can help prevent muscle strength loss in overweight and obese adults who are taking the weight loss medication semaglutide while dieting. Researchers want to see if taking BIO101 pills twice daily for 21 weeks helps maintain leg …

This study aims to understand how a specific type of high-intensity interval training (HIIT) that mixes cardio and strength exercises affects the body over six months. Researchers will enroll 30 overweight or obese adults to see how this 'hybrid training' changes their muscle cel…

This is a small pilot study to see if it's practical to run a larger trial comparing two diets. Six adults with overweight or obesity will eat a diet high in ultra-processed foods and a standard American diet for two weeks each. Researchers will measure body weight and other heal…

This study aims to see if popular weight loss medications (semaglutide or tirzepatide), when combined with lifestyle coaching, can slow down a person's biological aging. Researchers will follow 440 adults in Singapore who are overweight or obese for six months in a real-world wei…

This study aims to understand how weight loss (using a medication called tirzepatide) and an arthritis drug (ixekizumab) change the body's tissues in people with psoriatic arthritis and obesity. Researchers will take small samples of skin, joint, and fat tissue from 45 participan…

This study aims to understand how a mother's weight, diet, and metabolic health might change the composition of her breastmilk. Researchers will follow 150 mother-infant pairs for 5 months to see if these changes in breastmilk are linked to the baby's growth and future risk of ob…

This study aims to understand how weight loss affects the body's calorie-burning process after eating (called dietary thermogenesis) in obese adolescents. Researchers will compare 30 obese teens before and after weight loss to normal-weight teens, measuring energy expenditure and…

This study aims to understand what happens to people's weight over time after they stop or change their treatment with the obesity medication semaglutide (Wegovy). Researchers will follow 3,000 patients in France with severe obesity to see how their weight changes and identify wh…

This study aims to understand if popular weight-loss medications (like Ozempic and Mounjaro) change how people perceive taste and their eating habits. Researchers will look back at the medical records of 150 adults in Italy who took these drugs for at least 12 weeks. The goal is …

This study aims to understand how the medication semaglutide (a drug for diabetes and weight loss) affects fat stored around vital organs like the heart, liver, and kidneys in people who have both type 2 diabetes and chronic kidney disease. Researchers will use MRI scans to measu…

This study aims to understand how common fatty liver disease is in adults who are overweight or have conditions like high blood pressure or diabetes. Researchers will screen up to 10,000 participants using questionnaires, blood tests, and liver ultrasounds to collect health data …