Weight-Loss drug may also protect heart arteries
NCT ID NCT07657676
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and doctors will use CT scans to measure changes in plaque and inflammation. The goal is to see if this drug can do more than just help with weight—it might also protect the heart.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Mazdutide (a weekly injection that targets gut hormones to help with weight and metabolism)
- What this could lead to
- If it works, this could point toward a treatment that slows heart disease progression in people who are overweight.
- What could go wrong
- This is a small, early-phase trial with only 116 participants, so results may not apply widely. The drug may not reduce plaque or could cause side effects like nausea or injection-site reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, Beijing Municipality, 100037, China
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