Weight loss drugs may turn back the biological clock, study hints

NCT ID NCT07444073

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study will follow 440 adults aged 40-89 who are starting a weight management program that includes drugs like semaglutide or tirzepatide along with lifestyle coaching. Researchers will measure changes in biological age using a blood-based aging clock over 6 months. The goal is to see if these treatments are linked to slower aging, not just weight loss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

semaglutide or tirzepatide

What this could lead to

If successful, this could show that common weight loss drugs may also slow the aging process, pointing toward new ways to extend healthy lifespan.

What could go wrong

This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by other factors like lifestyle changes, and the study is not yet recruiting.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • NOVI Health (T3 Health PTE LTD)

    Singapore, 068914, Singapore

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • National University of Singapore

    Singapore, 119077, Singapore