Weight loss drugs may turn back the biological clock, study hints

NCT ID NCT07444073

Not yet recruiting Knowledge-focused Sponsor: National University of Singapore Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study will follow 440 adults aged 40-89 who are starting a weight management program that includes drugs like semaglutide or tirzepatide along with lifestyle coaching. Researchers will measure changes in biological age using a blood-based aging clock over 6 months. The goal is to see if these treatments are linked to slower aging, not just weight loss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: semaglutide or tirzepatide
What this could lead to: If successful, this could show that common weight loss drugs may also slow the aging process, pointing toward new ways to extend healthy lifespan.
What could go wrong: This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by other factors like lifestyle changes, and the study is not yet recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGING OBESITY & OVERWEIGHT

Contacts and locations

Locations

NOVI Health (T3 Health PTE LTD)

Singapore, 068914, Singapore
National University of Singapore

Singapore, 119077, Singapore

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