OBESITY & OVERWEIGHT

This study is testing a new device called SEGER IDEA™ that helps surgeons close openings in the bowel during keyhole surgery. It is the first time this device is being used in humans. Ten adults having certain types of bowel surgery will take part. The main goal is to see if the …

This completed Phase 2 trial tested whether a daily injection of ROSE-010, a GLP-1 analogue, can reduce appetite and food intake in 40 overweight or obese women. Participants received either a low or high dose of ROSE-010 or a placebo, and researchers measured how much they ate a…

This study looked at how well adults with obesity or complicated overweight could stick to different very low-calorie ketogenic diets (VLCKD) in a real-world clinic. Participants chose one of four diet plans, ranging from all-natural foods to all meal replacements, and followed a…

This study tested whether personalized diet advice based on a person's gut bacteria could improve food choices and gut health in 50 adults with obesity in Colombia. Participants either got tailored diet recommendations or standard advice for 12 weeks. Researchers measured changes…

This study looked at whether weight-loss surgery (sleeve gastrectomy) is better than diet and medication for adults aged 65 and older with severe obesity and related health problems like type 2 diabetes, high blood pressure, sleep apnea, and knee arthritis. Sixty patients chose e…

This study looked at over 11,500 adults with overweight or obesity who used a breath acetone sensor and mobile app to track weight and learn healthy habits. Researchers analyzed existing data to see how much weight users lost after 12, 24, 52, and 104 weeks. The goal was to under…

This completed study looked at how intermittent fasting and the Mediterranean diet affect body composition and nutrition knowledge in 100 overweight or obese adults. Participants followed one of the two diets for a set period. The goal was to see which approach leads to better we…

This study looked at whether taking a protein supplement on fasting days during a 4-week alternate-day fasting program could help young men with overweight lose fat while keeping muscle. Twenty-six men aged 21 to 35 either ate a small meal (400-600 kcal) or the same meal plus a w…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested a 12-week diet and lifestyle program called the SWW Method in 85 women aged 35-75. The program included intermittent fasting, a high-protein diet, and other healthy habits. Researchers measured changes in blood sugar, weight, and other markers to see if it could…

This study tested whether a dietary supplement called NatureU Burn, made from African mango seed extract and inulin, can increase feelings of fullness after a sugary drink. Fourteen healthy adults took either glucose alone or glucose plus the supplement, then rated their fullness…

This study looked at whether taking Korean ginseng extract daily for eight weeks could reduce fatigue and improve exercise performance in healthy adults aged 20 to 50. Sixty participants were randomly assigned to receive either the ginseng extract or a placebo. The researchers me…

This study looked at whether changing how often women eat (meal frequency) can improve their confidence and reduce stress while dieting. It involved 72 women aged 25-55 who had a history of losing and regaining weight (weight cycling) and were overweight or obese. The goal was to…

This study looked at whether standing on a vibrating platform while doing foot exercises could improve ankle strength, balance, and body awareness in overweight and obese young adults. Twenty-six people took part in supervised sessions three times a week for eight weeks. The resu…

This study looked at whether adding TECAR therapy or shock wave therapy to standard treatment (complex decongestive therapy) could better reduce leg swelling in severely obese women with lymphedema. Forty-five women took part, receiving one of three treatments over four weeks. Re…

This study tested a new hand position called the 'hook technique' to see if it helps doctors give oxygen more effectively to obese patients (BMI 30-40) using one hand. 375 adults took part, and the researchers measured chest rise, oxygen levels, and other signs of good breathing.…

This study tested whether special food supplement capsules that release nutrients in the lower gut can increase appetite-regulating hormones and reduce food intake. Twenty adults with obesity took either the active supplement or a placebo on two separate days. The supplement incr…

This study looked at whether a 4-week mindful eating program could help adults with obesity reduce hedonic hunger—the desire to eat for pleasure, not just fuel. 82 participants either followed a weight loss diet alone or added weekly mindful eating sessions. Researchers measured …

This small study tested whether gummy candies made with maqui berry could help overweight adults control their blood sugar after eating a carb-rich meal. Ten participants ate white bread alone, or with maqui berry gummies, and had their blood sugar and antioxidant levels measured…

This completed pilot study tested a 6-week web-based program called Mind Your Heart in 37 adults who were university employees. The program combined DASH diet education with mindful eating training to improve eating habits and health measures like blood pressure and cholesterol. …

This study analyzed health records from over 450,000 adults with obesity and type 2 diabetes to see if adding a GLP-1 or SGLT2 drug early improves survival and kidney health. Researchers compared those who added the other drug class within 90 days to those who added a different d…

This study looked at 40 adults who had sleeve gastrectomy surgery for obesity. Researchers measured blood levels of fractalkine, a protein involved in inflammation, before and three months after surgery. The goal was to see how fractalkine levels change and whether those changes …

This study looked at whether adding moderate aerobic exercise during Ramadan fasting helps overweight adults lose more fat and improve heart health compared to fasting alone. Twenty-eight participants were split into two groups: one only fasted, the other fasted and exercised fiv…

This study tested whether adding omentopexy — stitching the omentum to the stomach — during sleeve gastrectomy changes stomach shape and emptying. Thirty-six adults having weight-loss surgery were randomly assigned to get the extra stitch or not. Researchers measured stomach angl…

This early-stage study tested a single injection of petrelintide, a potential weight-management drug, in 48 adults with a BMI of 27 or higher. Researchers wanted to see if using different concentrations of the drug changed how the body processes it or affected safety. Participant…

This study analyzed health records of over 200,000 adults with obesity and type 2 diabetes to see if taking GLP-1 drugs (like Ozempic) before a cancer diagnosis is linked to better survival and fewer complications after cancer. The researchers compared GLP-1 users to those on oth…

This study looked at how a single dose of the drug VCT220 behaves in people with moderate kidney problems compared to those with healthy kidneys. Researchers measured drug levels in the blood and checked for side effects. The goal is to find the right dose for people with kidney …

This study looked at whether two different doses of dietary supplements (DIM and Perilla oil) delivered to the lower gut can reduce appetite and food intake in adults with obesity. Sixteen participants fasted, took capsules, and had blood tests and hunger ratings over 8 hours. Th…

This study tested a web-based tool called WeDosify that helps doctors manage dosing of the weight-loss drug semaglutide for adults with overweight or obesity. Twenty participants who had recently started semaglutide used the tool over three months. The main goal was to see how ma…

This study looked at 150 adults with normal weight, overweight, or obesity to see if a nutrition plan based on both genes and body measurements works better than one based only on body measurements. Participants followed a six-month diet program, and researchers tracked changes i…

This study looked at 30 adults with overweight or obesity and at least one heart risk factor. Researchers wanted to see if losing at least 10% of body weight could improve heart structure and function. They used heart scans and blood tests to measure changes. The goal was to bett…

This study followed 22 adults with obesity who went through a standard diet program, starting with a very-low-calorie diet and then a regular weight loss diet with counseling. Researchers measured weight loss, body fat distribution, glucose metabolism, and inflammation over 12 mo…

This study looked at whether a 12-week walking program could change brain structure in 22 overweight adults who also had headaches. Participants either followed a diet plus walking or diet alone. Researchers measured brain gray and white matter volumes with MRI scans before and a…

This study from the University of Pisa examined how a very low calorie ketogenic diet (VLCKD) affects body weight and energy use over time in 17 people with obesity. Participants followed the diet and were then monitored for changes in body composition and 24-hour metabolism. The…

This completed study in Spain looked at 821 first-year university students to see how their physical activity and sitting habits relate to obesity and muscle health risks. Researchers used questionnaires to measure activity levels and sitting time, and body mass index (BMI) to cl…

This completed study looked at how tirzepatide, a weight-loss drug, works in real-world settings for two groups: people who regained weight after gastric sleeve surgery, and those preparing for obesity surgery. Researchers tracked weight and metabolic changes over 6 months in 254…

This study looked at 40 people with severe obesity who had laparoscopic sleeve gastrectomy, a type of weight-loss surgery. Researchers measured levels of a protein called isthmin in the blood before surgery and three months after. The goal was to see if isthmin, which is linked t…

This study looked at how sleep quality, when people eat, and gut bacteria are linked to obesity. Researchers tested a mobile app to help people make healthier lifestyle changes. The study included 133 adults with different body weights, including some with sleep apnea. The goal w…

This study looked at whether a simple CT scan before weight-loss surgery can help predict when the original surgical plan might need to change during the operation. Researchers reviewed data from 288 adults who had planned gastric bypass surgery, comparing those whose surgery cha…

This early-stage trial tested whether a new probiotic bacterium called Phascolarctobacterium faecium is safe and well-tolerated when taken daily as a pill for 15 days. Twenty adults—some with normal weight and some with overweight or early blood sugar issues—participated. Researc…

This study tested whether giving two weight-loss drugs, cagrilintide and semaglutide, in one combined injection works as well as giving them separately. Forty adults with overweight or obesity received weekly injections for 22 weeks. The main goal was to see how the drugs' levels…