Food supplements that curb appetite show promise in small study

NCT ID NCT07448519

Completed Symptom relief Sponsor: Queen Mary University of London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether special food supplement capsules that release nutrients in the lower gut can increase appetite-regulating hormones and reduce food intake. Twenty adults with obesity took either the active supplement or a placebo on two separate days. The supplement increased levels of hormones that signal fullness and reduced calorie intake at lunch in female participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Colonic-delivered DIM and Perilla oil
What this could lead to: If it works, this could lead to a natural supplement that helps control appetite and reduce calorie intake in people with obesity.
What could go wrong: This was a small, early study with only 20 participants, so results may not apply to everyone. The supplement only showed effects in female volunteers, and long-term safety and effectiveness are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APPETITE REGULATION OBESITY & OVERWEIGHT

Contacts and locations

Locations

Wingate Institute of Neurogastroenterology

London, E1 2AJ, United Kingdom

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