Can vyvanse curb Post-Surgery binge eating? new trial aims to find out

NCT ID NCT04599504

Completed Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This study tests whether the medication lisdexamfetamine (Vyvanse) can help people who experience loss-of-control eating after bariatric surgery and didn't improve with earlier treatments. About 60 adults who had gastric bypass or sleeve gastrectomy will receive either the drug or a placebo daily for several months. Researchers will track changes in eating episodes and body mass index to see if the medication offers real benefits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lisdexamfetamine (Vyvanse)
What this could lead to: If it works, this could offer a medication option to help people who struggle with loss-of-control eating after bariatric surgery, potentially improving their weight outcomes.
What could go wrong: This is a small, early-stage trial with only 60 participants, so results may not apply to everyone. The medication may cause side effects or not work better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

binge eating disorder Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOSS-OF-CONTROL EATING OBESITY & OVERWEIGHT

Contacts and locations

Locations

Yale School of Medicine

New Haven, Connecticut, 06519, United States

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