New endoscopic combo procedure aims to tackle obesity without surgery

NCT ID NCT07612527

Recruiting now Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This Phase 2 trial tests a minimally invasive endoscopic procedure for weight loss in 10 adults with obesity (BMI 30-40, or 27-29.9 with related health issues). The procedure combines two techniques: one to reduce appetite by ablating part of the stomach lining, and another to slow digestion by cutting a muscle in the stomach. The goal is to achieve significant weight loss without the need for surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Endoscopic procedure (gastric fundal mucosal ablation and bariatric endoscopic antral myotomy)
What this could lead to: If successful, this could offer a less invasive, lower-cost alternative to surgery for weight loss in people with obesity.
What could go wrong: This is a very small early-phase trial with only 10 participants, so results may not apply widely. The procedure is new and its long-term safety and effectiveness are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARIATRIC ENDOSCOPY OBESITY & OVERWEIGHT

Contacts and locations

Locations

Kar-Alaini hospital (Cairo Univeristy hospital)
RECRUITING

Cairo, Egypt

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