New combo pill aims to melt fat, not muscle, in weight loss

NCT ID NCT07446998

Recruiting now Disease control Sponsor: Veru Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 02, 2026 · Updated 4 times

Summary

This Phase 2b trial tests whether adding enobosarm (a muscle-preserving drug) to semaglutide (a weight-loss drug) helps older adults lose more fat and keep muscle. About 200 people aged 65 and older who are overweight or obese will take both drugs or semaglutide alone. The goal is to see if the combo improves weight loss and physical function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: enobosarm (a selective androgen receptor modulator) combined with semaglutide (a GLP-1 drug for weight loss)
What this could lead to: If successful, this combination could help people lose fat while keeping muscle, improving physical function and weight management.
What could go wrong: This is an early Phase 2b study with only 200 participants. The drug combination may not work as hoped or could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HOMA-IR MOBILITY DISABILITY OBESITY & OVERWEIGHT

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

ALSA Research
RECRUITING

New York, New York, 10016, United States
Centennial Medical Group (CMG)
RECRUITING

Columbia, Maryland, 21045, United States
Coastal Research Institute, LLC
RECRUITING

Fayetteville, North Carolina, 28304, United States
DM Clinical - Dallas
RECRUITING

Irving, Texas, 75061, United States
DM Clinical - Seattle
RECRUITING

Seattle, Washington, 98122, United States
DM Clinical Research - MIA
RECRUITING

Doral, Florida, 33166, United States
DM Clinical Research - Phoenix
RECRUITING

Phoenix, Arizona, 85012, United States
IMIC Research a Rovia Clinical Research Company
RECRUITING

Miami, Florida, 33176, United States
Paramo Health
RECRUITING

Miami, Florida, 33175, United States
Paramo Health
RECRUITING

Miami, Florida, 33176, United States
Pennington Biomedical Research Center
RECRUITING

Baton Rouge, Louisiana, 70808, United States
SKY Integrative Medical Center
RECRUITING

Ridgeland, Mississippi, 39157, United States
UD Research
WITHDRAWN

Atlanta, Georgia, 30342, United States
Universal Axon Clinical Research (Rovia - UACR)
RECRUITING

Doral, Florida, 33166, United States

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