Radioactive sugar tracer reveals hidden metabolic pathways in obesity
NCT ID NCT07690176
First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time
Summary
This study investigates how the body processes glucose after a high-sugar meal in lean individuals and those with obesity. Participants drink a tiny, safe amount of radioactive glucose so researchers can trace exactly where the sugar goes—into breath, urine, or stool—and measure whether a lesser-known pathway (the polyol pathway) is more active in obesity. The goal is to understand fundamental differences in glucose metabolism that could explain why obesity increases the risk of diabetes and other metabolic disorders.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- low-glycemic breakfast with 14C-glucose microtracer
- What this could lead to
- If successful, this could reveal why obesity alters glucose processing, potentially pointing to new targets for managing or preventing metabolic disease.
- What could go wrong
- This is a small, early-stage observational study (24 people) that measures metabolic pathways, not clinical outcomes. Results may not apply to broader populations or lead directly to treatments.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Wageningen University and Research
RECRUITINGWageningen, 6708 WD, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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