DIABETES MELLITUS

This study tests whether giving the antibiotic vancomycin directly into the bone (intraosseous) during diabetic foot amputation works better than the standard IV method to prevent surgical site infections. It includes 40 adults with diabetes who need a below-knee amputation. Rese…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This large study tested whether evolocumab (Repatha), a cholesterol-lowering injection, could reduce major cardiovascular events like heart attacks, strokes, or death in over 12,000 adults at high risk but without a prior heart attack or stroke. Participants received either evolo…

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into…

This study tested whether adding a smartphone app with short videos on mental health, diet, exercise, and insulin adjustment to standard care could improve blood sugar control and birth weight in pregnant women with diabetes. Over 600 women participated. The goal was to see if th…

This early-phase study tested whether a single infusion of donor stem cells could help repair damaged blood vessels in 26 adults with type 2 diabetes and symptomatic heart disease. Researchers measured blood vessel function and looked for signs of repair in the lab. The goal was …

This study followed 543 adults aged 18-60 who had bariatric surgery at four hospitals in Norway. Each hospital used a different surgical method, allowing researchers to compare how well each approach helped with weight loss and type 2 diabetes remission. The goal was to find whic…

This study tested a next-generation automated insulin delivery system in 48 adults with type 2 diabetes aged 16–70. The goal was to see if the smart algorithm could keep blood sugar in a safer range, reducing both low and high blood sugar events. Participants used a continuous gl…

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This study tested a device called VasQ that wraps around a surgically created blood vessel connection (fistula) used for dialysis in people with kidney failure. The device is designed to improve blood flow and reduce complications. 144 patients received the device and were follow…

This study tested whether a mobile app helps elderly people (70+) with diabetes better control their blood sugar, maintain physical function, and improve quality of life. Sixty participants were split into two groups: one used the app, the other did not. The app was designed to b…

This study looked at whether giving diabetes patients who are at risk for food insecurity money to buy fruits and vegetables, along with nutrition education, can improve their blood sugar control and reduce emergency room visits. Over 2,000 adults participated, with one group rec…

This study tested whether a continuous glucose monitor (CGM) that alerts nurses to high or low blood sugar can help surgical patients with diabetes keep their glucose levels in a safe range. About 200 adults with diabetes who had surgery wore the Dexcom G7 device for up to 10 day…

This study looked at whether keeping blood sugar very low (under 130 mg/dL) is better than standard control (130-180 mg/dL) for non-critically ill patients with diabetes in the hospital. Researchers tracked 600 patients for complications like death, severe low blood sugar, infect…

This early study tested whether transplanting insulin-making islet cells could help people with type 1 diabetes who already had a kidney transplant. Only 3 patients took part, and they stayed on anti-rejection drugs. The goal was to see if the procedure was safe and could reduce …

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested a special educational tool for parents of children under 6 with type 1 diabetes. The goal was to see if the tool could help parents better control their child's blood sugar and prevent serious events like low blood sugar or ketosis. The study enrolled 24 childre…

This study tested a fiber-enriched, low-sodium liquid formula as the sole nutrition for 32 tube-fed nursing home residents with diabetes. Over three months, researchers measured changes in blood sugar, blood pressure, and nutritional status. The goal was to see if this special fo…

This study tested a telenursing program that gave health education and lifestyle advice to 70 adults with type 2 diabetes in Bangladesh. Participants used their smartphones to get support from nurses on diet, exercise, and medication. The goal was to see if this approach could im…

This study tested whether joining a peer support group helps people with diabetes better follow their medication plan, take care of themselves, and understand their condition. 120 adults with diabetes were split into two groups: one that joined a peer support group and one that c…

This pilot study tested whether combining financial navigation (help with costs) and peer support (connecting with others) can help adults with diabetes better manage their condition. 61 participants were randomly assigned to receive either financial navigation alone or financial…

This study tested whether levodopa, a drug used for Parkinson's disease, can help people with diabetes who have early signs of eye damage (diabetic retinopathy). The goal was to find the best dose and understand how it works to improve the retina's electrical signals. 230 adults …

This study looked at 100 liver transplant patients with diabetes to see if dapagliflozin or sitagliptin is better at reducing liver fat and improving body composition. Participants took one of the two drugs for 12 months. The goal was to find a safer and more effective way to man…

This study tested a web-based app called Mobile Diabetes Detective (MoDD) in 248 adults with type 2 diabetes. The app helps users identify problems with blood sugar control and suggests better behaviors. Researchers measured changes in blood sugar (HbA1c), problem-solving skills,…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This pilot study tested whether using smart insulin pens together with continuous glucose monitors (CGMs) can improve blood sugar control in adults with type 2 diabetes. Thirty participants used these devices to track their glucose levels and insulin doses. The goal was to see if…

This study looked at how well the Xience Sierra drug-coated stent works in a broad group of heart disease patients, including those with diabetes or prediabetes. Over 1,700 participants received the stent during a routine procedure to open blocked arteries. Researchers tracked he…

This study tested whether a virtual weight control program combined with a continuous glucose monitor could help adults with type 2 diabetes lower their blood sugar levels. 152 overweight or obese adults with type 2 diabetes participated. The program used the WW (Weight Watchers)…

This study tested a small, wearable sensor that sits just under the skin and measures blood sugar continuously for up to 5 days in adults with diabetes. 247 participants wore the sensor along with a standard monitor and took fingerstick tests to compare accuracy. The goal was to …

This study tested the safety and effectiveness of the Omnipod 5 SmartAdjust 2.0 system, an automated insulin pump, in 48 people aged 2 to 70 with type 1 or type 2 diabetes. The system uses a continuous glucose monitor to automatically adjust insulin delivery. The main goals were …

This study tested whether adding a community health worker to the diabetes care team helps children with type 1 diabetes. The health worker provided home visits, social support, and help with setting health goals. The study included 84 children and looked at blood sugar control, …

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve kidney, heart, and pancreas function in teens aged 12-21 with type 2 diabetes and obesity. Researchers measured blood flow to the kidneys, kidney filtering ability, and insulin production b…

This study looked at whether alerts from continuous glucose monitors (CGMs) help hospital patients with type 1 or 2 diabetes manage their blood sugar better. Over 500 adults who needed intensive insulin therapy took part. The main goal was to see if alerts increased the time bloo…

This early study tested a device that uses mild electric pulses to regenerate the lining of the upper small intestine in 20 adults with type 2 diabetes. The goal was to see if the procedure is safe and could help lower blood sugar. Participants were on 2-3 diabetes pills and had …

This early-phase study tested whether a new type of immune cell, called a tolerogenic dendritic cell, is safe for people with type 1 diabetes. The cells were made from each patient's own blood and designed to calm the immune system attack on the pancreas. 32 participants received…

This completed study tested whether a diabetes-specific tube-feeding formula (Nutren Diabetes) can control blood sugar as well as another formula (Fresubin Diabetes) in diabetic patients who have trouble swallowing. 233 adults aged 18-90 took part, receiving tube feeding for up t…

This study tested whether babies with a rare, permanent form of diabetes caused by specific gene changes could switch from daily insulin injections to an oral pill called glibenclamide. Nineteen infants took part. The goal was to see if the pill could control their blood sugar an…

This study tested whether taking aspirin twice a day (200 mg total) works better than the standard once-daily dose (100 mg) to prevent another heart attack, stroke, or urgent heart procedure in diabetic patients who recently had a heart attack. About 2,500 participants were follo…

This study looked at whether people with diabetes and a high risk of bleeding can safely stop taking two blood thinners (DAPT) just one month after getting a special stent, instead of the usual six months. Doctors used a special camera (OCT) to check if the artery had healed enou…

This study looked at whether adding vitamin B12 to the diabetes drug dapagliflozin improves blood sugar control in people with type 2 diabetes. Eighty volunteers took either dapagliflozin alone or dapagliflozin plus vitamin B12 for 12 months. Researchers measured HbA1c levels to …

This study tested two antibiotic gels (metronidazole and minocycline) in 380 adults with both diabetes and gum disease. Participants received deep cleaning alone or with one or both gels. Researchers checked gum pocket depth and gum color/texture at 7 and 15 days to see which tre…

This study tested a medication called tirzepatide in children and teenagers aged 10 to 17 with type 2 diabetes. Participants were already taking metformin or insulin but still had high blood sugar. The goal was to see if tirzepatide could safely lower blood sugar levels better th…

This completed study tested a comprehensive strategy to help manage high blood pressure and diabetes in primary care clinics in Brazil. Over 5,800 adult patients from resource-limited areas took part. The strategy included telehealth tools, education for healthcare workers, and s…

This pilot study tested whether high doses of omega-3 fatty acids (fish oil) and vitamin D are safe and can help preserve insulin production in people with type 1 diabetes. The trial included 27 participants, both children and adults, who had diabetes for up to 10 years. Research…

This study tested whether using Zoom for doctor visits (telecare) works as well as in-person visits for managing diabetes. 780 adults with diabetes in Hong Kong were assigned to either video consultations or usual face-to-face care. Researchers tracked blood sugar (HbA1c) and cho…

This study tested a new way to help people aged 60 and older with type 2 diabetes manage their condition. Instead of traditional finger-prick blood tests, participants wore a non-invasive sensor on their wrist to track glucose levels. They also received personalized coaching via …

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study looked at whether measuring ferritin (a marker of iron stores) in early pregnancy can help predict which women will later develop gestational diabetes. Researchers followed 556 pregnant women, measuring their ferritin and other blood markers early on. The goal was to s…

This completed trial tested how accurately the True Vie I3 continuous glucose monitor measures blood sugar levels in 159 adults with type 1 or type 2 diabetes. Participants wore the device while researchers compared its readings to standard lab measurements. The goal was to see i…

This study tested several simple bedside tests—like ankle and toe blood pressure measurements and handheld Dopplers—to see how well they detect poor leg circulation (peripheral arterial disease) in 604 people with diabetes. The results were compared to advanced imaging scans (CTA…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study tested whether a structured educational program could help people with diabetes prevent foot ulcers. 42 adults with diabetes attended two specialist-led sessions or received standard care. The education group showed better foot care knowledge and habits, and no one dev…

This study tested custom-made insoles for people with diabetic foot to see if they improve balance and walking. Twenty-five participants aged 40 to 65 with early-stage diabetic foot issues were included. The insoles were designed using pressure measurements to offload high-pressu…

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This study tested a new method called inforatio to help heal diabetic foot ulcers. The technique involves making small cuts in the wound to trigger the body's natural healing response. 100 adults with diabetes and foot ulcers that had not healed for at least 6 weeks took part. Th…

This study tested whether Baduanjin, a traditional Chinese exercise that combines gentle movements with mindful breathing, can help people with type 2 diabetes. 42 adults aged 50-60 with diabetes for 5-10 years took part. Researchers measured changes in blood sugar, quality of li…

This study tested a program where community health workers helped young adults (ages 18-35) from underrepresented minority groups with type 1 diabetes start using devices like continuous glucose monitors and insulin pumps. Over 9 months, 119 participants were randomly assigned to…

This study tested whether foot-ankle exercises and walking exercises can reduce foot nerve pain, stress, and improve quality of life in people with type 2 diabetes. 375 adults with diabetes were split into three groups: foot-ankle exercises, walking exercises, or standard care. T…

This study tested whether gargling with hawthorn vinegar, black mulberry syrup, or green tea could improve oral health and quality of life in 120 adults with diabetes who had mouth sores (mucositis). Participants used one of the three gargles three times a day for 14 days alongsi…

This study tested whether training healthcare providers to prescribe continuous glucose monitors (CGMs) increases their use among patients with type 2 diabetes. Researchers trained clinic staff at three community health centers serving a mostly Hispanic/Latino population. They th…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This completed study looked at how well Danish hospitals followed official guidelines for managing blood sugar in people with diabetes who had major, non-cardiac surgery. Researchers reviewed records from over 13,000 patients treated between 2017 and 2023. They focused on whether…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study looked at how different ways of taking a blood sample from a finger affect blood sugar readings in people with diabetes. Researchers compared the first and second drops of blood, and also tested with and without squeezing the finger. The goal was to find the most accur…

This study checks if a program called COPE helps Navajo people with diabetes and related health problems. The program uses community health workers to support patients and connect them with doctors. Researchers compared nearly 29,000 people who took part in COPE with those who di…

This completed study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. 78 adults were divided into three groups: those with sleep apnea, those with diabetes or high blood pressure, and healthy people.…

This study tested a Turkish version of a questionnaire that helps people with diabetes take better care of their feet to prevent ulcers. Researchers interviewed 202 adults with diabetes to see if the tool was accurate and reliable. The tool covers daily foot care, checking for ea…

This completed study looked at whether the Dexcom G7 continuous glucose monitor stays accurate in diabetes patients who have poor blood circulation during hospital stays. Researchers compared CGM readings to standard finger-stick blood tests in 60 adults undergoing surgery or in …

This study used ultrasound to measure how much fluid remains in the stomach after standard preoperative fasting in 592 adults scheduled for elective surgery. Researchers compared diabetic and non-diabetic patients to see if diabetes affects stomach emptying. The goal is to help t…

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar, weight, and kidney function for up to a year after leaving the hospital. The goal was to learn how COVID-19 affects long-term diabetes control and to…

This study tested a computer tool that helps doctors classify the type of diabetes in adults diagnosed before age 50. Researchers interviewed 21 patients and staff to see if the tool was useful and acceptable. The goal is to gather initial data for a future, larger trial.

This study followed 99 people who had both an operable pancreatic tumor and diabetes for one year after surgery. Researchers tracked their fatigue, blood sugar control, diabetes self-care, and quality of life to understand how these factors change over time. The goal was to learn…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This study looked at the gut bacteria of 200 heart attack patients, comparing those with high blood sugar to those with normal levels. Researchers collected stool samples before treatment and again at 6 and 12 months to see if changes in gut bacteria relate to survival. The goal …

This pilot study tested whether continuous glucose monitors (CGMs) can help manage blood sugar in hospitalized adults with diabetes. Forty patients wore a Dexcom G6 device during their hospital stay to track glucose levels. The goal was to see if CGM could reduce dangerous low or…

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This pilot study tested a new program to help prevent low blood sugar (hypoglycemia) in people with diabetes who take medications that can cause it. The program included a patient survey and a toolkit for doctors. The study involved 35 patients and their primary care providers at…

This study looked at whether giving metoclopramide, a drug that speeds up stomach emptying, helps diabetic patients have less stomach fluid before surgery. 60 adults having elective surgery were checked with ultrasound to measure stomach contents. The goal was to see if the drug …

This study tested five different blood glucose meters in 501 adults with type 1 or type 2 diabetes who use insulin. Participants used multiple devices to see how accurate and reliable each meter is in real-world conditions. The goal was to help people with diabetes and their doct…

This study explored why some people with latent (inactive) tuberculosis (TB) are more likely to develop active TB. Researchers looked at 626 people in South India to see how malnutrition, diabetes, and worm infections might change the body's response to TB. Participants gave bloo…

This study tested whether a rapid DNA sequencing method (mNGS) could better identify bacteria in diabetic foot ulcers compared to standard lab cultures. 44 adults with diabetes and an infected foot ulcer had tissue samples analyzed using both methods. The goal was to see if this …

This completed study tested two strategies to improve diabetes care in older adults: giving doctors regular feedback on their patients' diabetes control, and assigning a diabetes resource nurse to coordinate care. About 1,891 people aged 65 and older with diabetes and Medicare to…

This study looked at how the experimental diabetes drug HRS-7535 behaves in people with mild or moderate liver impairment compared to those with normal liver function. Twenty-four adults completed the trial, which measured drug levels in the blood and checked for side effects. Th…

This study tested a special imaging method (SPECT/CT) to measure blood flow in the leg muscles of people with peripheral arterial disease (PAD) and diabetes. Researchers compared these images to those from healthy volunteers to see how treatment affects muscle blood flow. The goa…

This study measured three substances in the blood (endocan, alarin, and galanin-like peptide) in people with and without diabetic retinopathy, an eye complication of diabetes. Researchers compared these levels across different stages of the disease and looked at how they relate t…

This study tested whether taking acetaminophen (like Tylenol) interferes with a new continuous glucose monitor called Biolinq. Thirty-one adults with diabetes wore the Biolinq sensor and a standard CGM for three days. On day three, they took acetaminophen and researchers compared…

This study tested a program called ImPart-Multi, where a trained helper (lay navigator) coached Black patients with chronic kidney disease and their care partners on how to work together when making health decisions. 22 patients and their care partners joined, and patients comple…

This completed study looked at how physical activity, life satisfaction, and medication adherence are related in 82 older Turkish adults (65+) with chronic conditions like high blood pressure or diabetes. Researchers used surveys to measure each factor. The goal was to understand…

This study explored whether malnutrition makes it harder for foot sores to heal in people with diabetes. Researchers followed 75 patients with type 1 or 2 diabetes who had a foot sore for 1 to 24 months. They measured how many sores healed and checked for signs of malnutrition. T…

This study tested a set of strategies to help community health centers routinely identify and act on social needs (like food or housing insecurity) for patients with or at risk for diabetes. Researchers used a tool built into electronic health records to collect this information.…

This study looked at how different shoe fit guidelines affect pressure inside the shoe for people with diabetes and nerve damage. Researchers measured foot pressure while 26 participants walked in standardized shoes with different toe gap sizes. The goal was to see which fit guid…

This study looked at whether viral infections and diabetes in pregnant women are linked to congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future lar…

This study tested whether regular meetings between different types of doctors could work well in a hospital to help people with diabetes and other chronic conditions. 55 patients joined, and researchers tracked how often the meetings happened, if doctors followed the recommendati…

This completed study looked at how muscle size and strength change in older adults with type 2 diabetes during bed rest and exercise. Researchers studied 95 participants to find targets for future treatments to prevent muscle loss and disability. The goal is to improve health and…

This completed study followed 1,290 adults with type 1 or type 2 diabetes for two years. Researchers tracked mental health issues like depression, anxiety, and eating problems alongside daily blood sugar levels using smartphone surveys and continuous glucose monitors. The goal wa…

This completed study looked at 542 adults to see if having more leg fat is linked to a lower risk of type 2 diabetes, and whether belly fat plays a role in that link. Researchers used body scans and statistical models to explore these connections separately for men and women. The…

This pilot study tested whether giving financial rewards for walking and healthy food could help low-income adults with obesity or diabetes. Eight participants were split into two groups: one received incentives, the other did not. The goal was to see if this approach could reduc…

This completed study looked at 58 adults with diabetes to find out which physical symptoms most affect their balance. Participants did a simple stepping test and answered questions about their daily activity. The goal was to understand the connection, not to test a treatment.

This study looked at 278 diabetic patients to see if the same staph bacteria found in their noses also appear in their foot ulcers. Researchers compared the genetic fingerprints of the bacteria to understand the link. The goal was to learn more about infection risks, not to test …

This study looked at whether web-based childbirth education helps pregnant women bond with their baby and feel less fear about giving birth. 120 pregnant women in Turkey took part. The researchers measured attachment and fear levels using questionnaires. The goal was to see if on…

This pilot study tested a quality improvement process called CUSP to help community mental health staff deliver better care for cardiovascular risk factors like high blood pressure, diabetes, and high cholesterol. The study included 85 staff and patients from psychiatric rehabili…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This completed study looked at gut bacteria in 90 adults with obesity, type 2 diabetes, or neither. Researchers collected samples from the small intestine and colon during routine endoscopies. They compared these to stool samples to see which bacteria are linked to metabolic heal…

This study looked at how pressure on the soles of the feet relates to balance in 32 adults with diabetic foot. Participants stood on special pressure mats and balance boards under different conditions. The goal was to find patterns that could help prevent foot ulcers and falls.

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This study tested a clinical decision support tool that helps doctors identify social needs—like food, housing, or transportation—in African American patients with chronic diseases such as diabetes or heart failure. The tool uses a social risk score to flag patients who may need …

This study looked at whether using telemedicine (video or phone consultations) can help people in rural communities with leg wounds get specialist care more quickly. Researchers compared the time from when a wound was found to when a specialist saw the patient, either through tel…

This completed study in Cameroon followed 406 adults with and without type 2 diabetes for one year. Researchers tested blood and stool samples at four time points to see if diabetes increases the risk of malaria and other parasitic infections. The goal is to understand how non-co…