DIABETES MELLITUS

This study tested if babies with a rare, permanent form of diabetes caused by specific genetic mutations could safely switch from daily insulin injections to an oral pill called glibenclamide. It involved 19 infants and young children to see if the pill could control their blood …

This study tested a new liquid nutrition formula designed for diabetic patients who cannot eat by mouth and need tube feeding. Researchers compared it to an existing formula to see if it was just as good at controlling blood sugar levels. Over 200 adult patients with diabetes par…

This study tested different ways to help doctors provide better care for older adults with diabetes. Researchers gave some doctors feedback reports on their patients' test results and care, while other clinics also received a dedicated diabetes nurse to help coordinate care. The …

This small, completed study tested if a clinical trial could be run remotely to find the best personalized drug plan for protecting the kidneys of people with type 2 diabetes. Twelve participants tried a drug called empagliflozin at home, and based on their kidney test results, s…

This early-phase study tested the safety of a new cell therapy for people with type 1 diabetes. Doctors took cells from 32 patients, modified them in a lab, and gave them back. The goal was to see if these 'tolerogenic' cells could teach the immune system to stop attacking the pa…

This study tested whether taking a low dose of aspirin twice a day is better than once a day at preventing future heart attacks, strokes, or other serious heart problems in people with diabetes or obesity who recently had a heart attack or chest pain. Researchers enrolled over 2,…

This study tested whether a special liquid diet, high in fiber and low in salt, could help manage diabetes in nursing home residents who are fed through a tube. For three months, 32 participants received this formula as their only source of nutrition. Researchers then checked if …

This study tested whether adding a vitamin B12 supplement to a standard diabetes medication (dapagliflozin) helps control blood sugar better. It involved 80 people with type 2 diabetes who were already taking the medication. Researchers compared blood sugar levels over one year b…

This study tested a new way to help older adults manage their diabetes. It compared a painless, wearable glucose monitor paired with a smartphone app against the traditional finger-prick method. The goal was to see if the tech-based approach made it easier for 60 participants to …

This study tested whether adding antibiotic gels to a standard dental cleaning improves gum health for people with diabetes who have periodontitis (serious gum disease). 380 patients were divided into four groups to compare cleaning alone versus cleaning plus one or two different…

This study tested whether two simple exercise programs could help people with type 2 diabetes. Researchers compared a specific foot-ankle exercise routine, a walking program, and standard education to see which best improved foot nerve health, stress, and quality of life over 12 …

This study tested whether specially trained community health workers could help young adults from underrepresented minority groups start and keep using diabetes technology like continuous glucose monitors and insulin pumps. For 9 months, 119 participants were randomly assigned to…

This study tested a new endoscopic procedure that aims to regenerate the lining of the small intestine to help control type 2 diabetes. Researchers enrolled 20 adults whose diabetes wasn't well-controlled on 2-3 non-insulin medications. The main goal was to check if the procedure…

This small, early-stage study tested whether taking high doses of omega-3 fatty acids and vitamin D is safe and might help people with type 1 diabetes. The goal was to see if these supplements could protect the body's remaining insulin-producing cells, potentially slowing the dis…

This study tested whether a mobile phone app called Mobile Diabetes Detective (MoDD) could help adults with type 2 diabetes. The app was designed to teach problem-solving skills for daily diabetes management. Researchers wanted to see if using the app led to better blood sugar co…

This study tested whether special alerts from continuous glucose monitors help hospitalized diabetes patients manage their blood sugar better. Researchers enrolled 533 adults with type 1 or type 2 diabetes who needed intensive insulin therapy while in the hospital. They compared …

This study tested a new way to decide which older adults should get extra help from a care coordinator. Researchers wanted to see if asking people about their own difficulties managing care was better at preventing emergency room visits and hospital stays than the usual method, w…

This study tested the safety and effectiveness of an updated automated insulin pump system for people with type 1 or type 2 diabetes. It involved 48 participants, from children to adults, who used the system for several weeks to see if it could keep their blood sugar in a healthy…

This trial tested whether a new minor procedure called the 'inforatio technique' could help diabetic foot ulcers heal faster. One hundred patients with these hard-to-heal sores were randomly assigned to receive either standard wound care alone or standard care plus this new techn…

This small pilot study tested whether helping people with diabetes manage their medical costs and connecting them with a supportive peer could improve their health. 61 adults with diabetes who reported financial stress were randomly assigned to receive either financial help alone…

This study tested if diabetic patients at high risk of bleeding could safely stop taking two blood-thinning drugs (DAPT) early after getting a heart stent. Doctors used a high-resolution scan (OCT) to check if the artery had healed enough one month after the procedure. If it had,…

This study looked at a community health program called COPE that has been running in the Navajo Nation since 2009. It aimed to see if the program helped people with diabetes better manage their condition by improving blood sugar, blood pressure, and other health measures. Researc…

This study tested whether a virtual weight management program, combined with a continuous glucose monitor, could help adults with type 2 diabetes better control their blood sugar. 152 participants were assigned to either try this digital program or continue with their usual care …

This study tested whether regular video call check-ups with healthcare providers could help people with diabetes better manage their condition. It involved 780 adults in Hong Kong who had diabetes and were already seeing a doctor regularly. Researchers measured things like averag…

This study looked at whether weight-loss surgery (sleeve gastrectomy) could improve the health of the pancreas, kidneys, and heart in young people (ages 12-21) with type 2 diabetes. Researchers measured organ function in about 50 participants before and after surgery to understan…

This study compared two common diabetes pills, dapagliflozin and sitagliptin, in 100 people with diabetes who had received a liver transplant. The main goal was to see which drug was better at reducing fat buildup in the new liver and improving body composition (like reducing bel…

This study tested whether stem cells from healthy donors could help repair damaged blood vessels in people with both diabetes and symptomatic heart disease. Researchers compared the effects of a single infusion of these cells against a placebo in 26 participants. The main goal wa…

This study tested a new computer tool for doctors. The tool automatically flags patients with chronic diseases who may also be struggling with needs like stable housing, food, or transportation. Doctors could then refer these patients to community organizations for help, aiming t…

This study tested a new, multi-part strategy to help people better manage high blood pressure and diabetes in Brazil's public health clinics. It involved nearly 6,000 patients and compared new methods—like telehealth tools, text messages, and extra training for doctors—to standar…

This study tested whether practicing Baduanjin, a traditional Chinese exercise, could help people with type 2 diabetes better manage their condition. Researchers worked with 42 adults who had diabetes for 5-10 years to see if the gentle movements could lower stress hormones, impr…

This study tested whether adding a trained community health worker to a child's diabetes care team could help improve their blood sugar control. It involved 84 children with poorly controlled type 1 diabetes. The community worker provided personalized support for one year, helpin…

This small, completed pilot study tested if using newer technology could help people with type 2 diabetes manage their condition better from home. Researchers gave 30 participants smart insulin pens and continuous glucose monitors (CGMs) and used telemedicine for check-ins, compa…

This study tested a new support program for clinics to improve care for adults with multiple long-term conditions like HIV, diabetes, and high blood pressure. Over 1,800 participants in South Africa either received standard care or the new ENHANCE program, which included special …

This study tested a medication called tirzepatide in children and teenagers (ages 10-17) whose type 2 diabetes was not well-controlled with standard treatments like metformin or insulin. Over 60 weeks, researchers compared the drug to a placebo to see if it could better lower blo…

This study tested how well a new, under-skin glucose monitor works when people take acetaminophen (like Tylenol). 31 adults with diabetes wore the new monitor and a standard one for three days. On the final day, they took acetaminophen so researchers could check if the painkiller…

This study tested how well a new continuous glucose monitor (CGM) called the True Vie I3 tracks blood sugar levels in people with diabetes. 159 adults with type 1 or type 2 diabetes who use insulin wore the device for up to 15 days. Researchers compared the monitor's readings to …

This study tested a new, faster method to identify the specific bacteria causing infections in diabetic foot ulcers. Researchers compared the new test to standard lab cultures in 44 participants to see if getting results quicker could help doctors choose the best antibiotics soon…

This study tested a new wearable glucose monitor that sticks to the skin like a patch. 247 adults with diabetes wore the device for up to a week to see how accurately it measured blood sugar compared to standard fingerstick tests and lab equipment. The goal was to gather data to …

This study tested whether measuring iron levels in the blood early in pregnancy can predict which women will later develop gestational diabetes. Researchers followed 556 pregnant women, comparing iron markers between those who developed diabetes and those who didn't. The goal is …

This was a small, early-stage study to see if paying people makes it easier for them to adopt healthy habits. Researchers worked with 8 adults from a low-income community who were at risk for obesity and diabetes. They tested if offering money for walking and to buy healthy food …

This study tested whether watching online childbirth preparation videos could help pregnant women feel less fearful about giving birth and more connected to their unborn babies. Researchers worked with about 120 pregnant women, giving half of them access to a series of educationa…

This study tested a new imaging method to see if it could measure blood flow in the feet. Researchers compared scans from 34 healthy people and patients with diabetes and clogged leg arteries. The goal was to see if this scan could show how well a procedure to open blocked arteri…

This study aimed to find out if certain substances in the blood are linked to the severity of diabetic eye damage. Researchers compared blood samples and detailed eye scans from 90 adults, including people with and without diabetes. The goal was to see if measuring these blood ma…

This study aimed to understand how common health problems like malnutrition, diabetes, and worm infections might increase the risk of latent tuberculosis (TB) becoming active. Researchers in India enrolled 626 people with and without latent TB to measure how often these other con…

This study aimed to understand which diabetes symptoms most affect a person's balance. Researchers tested 58 adults with diabetes using walking and balance tasks and questionnaires. The goal was to identify key factors that increase fall risk to help guide better prevention and r…

This study compared how well five different brands of home blood glucose monitors worked for people with diabetes. It involved 501 adults with type 1 or type 2 diabetes who already used insulin and checked their blood sugar regularly. The goal was to see how accurate and reliable…

This study aimed to understand how mental health conditions like depression and anxiety affect blood sugar control in people with type 1 or type 2 diabetes. Researchers followed 1,290 participants for two years, using smartphone surveys and glucose monitors to track daily moods, …

This research study aimed to understand if viruses in pregnant women, especially those with diabetes, might increase the risk of heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to look for viruses and the body's immune response to them. …

This pilot study tested a new quality improvement program to help mental health providers better manage heart disease risk factors in their patients. Researchers worked with 85 participants from community mental health organizations to see if the program improved care for conditi…

This study aimed to understand if having type 2 diabetes changes a person's risk of getting malaria and other parasitic worm infections. Researchers in Cameroon followed 406 adults, some with diabetes and some without, for one year. They tested blood and stool samples regularly t…

This French research study aimed to understand the role of gut bacteria in obesity and type 2 diabetes. Researchers collected and analyzed bacteria samples from the small intestine and colon of 90 participants, including people with obesity, obesity plus diabetes, and a control g…

This study aimed to understand the link between how pressure is distributed on the soles of the feet and a person's balance when they have diabetic foot complications. Researchers measured 32 adults with early-stage diabetic foot using special pressure mats and balance boards und…

This study looked at 542 adults to understand how body fat location relates to type 2 diabetes. Researchers investigated whether having more fat in the legs might lower diabetes risk, and if belly fat plays a role in this connection. They also examined if this relationship works …

This study tested a new system to help community health centers ask patients about life challenges—like housing, food, or transportation—that can affect diabetes. Researchers worked with 30 clinics to see if training them to collect this information and connect patients to helpfu…

This study tested whether regular meetings between different types of doctors could work well in a hospital setting to coordinate care. It involved 55 patients who have diabetes along with at least one other chronic heart, lung, or kidney condition. The main goal was to see if th…

This study aimed to understand why muscle loss speeds up in older adults with type 2 diabetes or after a hospital stay. Researchers studied 95 older adults to examine how the body processes nutrients for muscle building under these conditions. The goal was to identify new biologi…

This study looked at how a potential new diabetes medication, HRS-7535, is processed by the body and how safe it is in people with mild to moderate liver problems compared to people with normal liver function. It involved 24 adults to measure the drug's levels in the blood and ch…

This study looked back at the health records of nearly 1 million Canadian adults to understand how the COVID-19 pandemic affected their regular care for long-term conditions like diabetes, heart failure, and depression. Researchers compared the number of doctor visits, tests, and…

This study aimed to understand the connection between inflammation and common health conditions like heart disease and diabetes. Researchers compared 150 adults with these conditions to healthy volunteers using blood tests, questionnaires, and special body scans. The goal was to …