Could Twice-Daily aspirin save diabetic hearts?

NCT ID NCT02520921

Completed Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether taking aspirin twice a day (200 mg total) works better than the standard once-daily dose (100 mg) to prevent another heart attack, stroke, or urgent heart procedure in diabetic patients who recently had a heart attack. About 2,500 participants were followed for 18 months. The goal was to see if splitting the dose reduces ischemic events without causing more bleeding.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aspirin (enteric coated)
What this could lead to: If successful, this could show that a simple change in aspirin dosing reduces the risk of repeat heart attacks or strokes in diabetic patients.
What could go wrong: This is a completed Phase 4 trial, but the benefit may be small and bleeding risk could increase with higher total aspirin dose. Results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

acute coronary syndrome coronary artery disorder diabetes mellitus Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE CORONARY SYNDROME CORONARY ARTERY DISEASE DIABETES MELLITUS OBESITY

Contacts and locations

Locations

Department of Cardiology - Lariboisiere Hospital

Paris, 75010, France

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