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New clinic program aims to tackle multiple chronic diseases in south africa

NCT ID NCT06248190

Completed Disease control Sponsor: University of KwaZulu Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health education materials, and home visits from community health workers. The goal was to see if this approach could improve detection of new conditions, treatment changes, and control of existing conditions compared to usual care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
health system intervention (clinical decision support tool, health education, training, and community health worker visits)
What this could lead to
If successful, this approach could help primary care clinics better manage patients with multiple chronic conditions like HIV, high blood pressure, and diabetes, leading to improved health outcomes.
What could go wrong
This is a completed implementation study, not a drug trial. The results may not apply to other settings or countries, and the intervention requires significant training and resources to maintain.

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Conditions

The condition(s) this trial relates to.

asthma Depression depressive disorder diabetes mellitus HIV infectious disease hypertensive disorder Multiple Chronic Conditions myocardial infarction stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA DEPRESSION DIABETES MELLITUS HIV INFECTIONS HYPERTENSION MYOCARDIAL INFARCTION STROKE

Contacts and locations

Locations

  • Caluza Clinic

    Pietermaritzburg, South Africa

  • Delft CHC

    Cape Town, Western Cape, 7700, South Africa

  • Dr Abdurahman CHC

    Cape Town, Western Cape, 7700, South Africa

  • DuNoon CHC

    Cape Town, Western Cape, 7700, South Africa

  • Durbanville CHC

    Cape Town, Western Cape, 7700, South Africa

  • Eastwood Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Elsies CHC

    Cape Town, Western Cape, 7700, South Africa

  • Esigodini Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Gcumisa Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Gomane Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Gugulethu CHC

    Cape Town, Western Cape, 7700, South Africa

  • Gustrouw CDC

    Cape Town, Western Cape, 7700, South Africa

  • Hanover Park CHC

    Cape Town, Western Cape, 7700, South Africa

  • Heideveld CHC

    Cape Town, Western Cape, 7700, South Africa

  • Howick Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Impilwenhle Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Injabulo Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Kleinvlei CHC

    Cape Town, Western Cape, 7700, South Africa

  • Kraaifontein CHC

    Cape Town, Western Cape, 7700, South Africa

  • Macassar CDC

    Cape Town, Western Cape, 7700, South Africa

  • Mafatini Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Michael M

    Cape Town, Western Cape, 7700, South Africa

  • Mitchells Plain CHC

    Cape Town, Western Cape, 7700, South Africa

  • Mphophomeni Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Ndaleni Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Northdale Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Pata Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Retreat CHC

    Cape Town, Western Cape, 7700, South Africa

  • Richmond Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Songonzima Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Vanguard CHC

    Cape Town, Western Cape, 7700, South Africa

  • Willowfontein CHC

    Pietermaritzburg, KwaZulu-Natal, South Africa

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