Could a worm enzyme soothe diabetic nerve damage?
NCT ID NCT07475065
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether an oral supplement called DLBS1033 (made from earthworm proteins) can reduce nerve damage symptoms in adults with diabetic polyneuropathy. Thirty-four people with type 2 diabetes will receive either the supplement or a placebo for 28 days, alongside standard care. Researchers will measure changes in neuropathy severity, inflammation, and nerve growth factors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- DLBS1033 (lumbrokinase)
- What this could lead to
- If it works, this could point toward a new add-on treatment to ease nerve pain and improve nerve health in people with diabetic polyneuropathy.
- What could go wrong
- This is a small, early-phase trial with only 34 participants and a short 28-day treatment period. Results may not apply to everyone, and the supplement may not prove effective.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dr. Moewardi Regional General Hospital
Surakarta, Central Java, 57143, Indonesia
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