New bone graft could cut infection in severe leg breaks
NCT ID NCT07227493
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at a new bone graft material called Fibergraft Aeridyan Matrix for treating open pilon fractures, which are severe breaks in the lower leg that often get infected or don't heal well. Researchers will follow 45 adults who need bone grafting as part of their standard care, using extra CT scans at 6 and 12 months to check healing. The goal is to see if this material reduces infection and helps bones heal better than current methods.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fibergraft Aeridyan Matrix (bioactive glass and collagen bone graft substitute)
- What this could lead to
- If successful, this could provide a better way to treat severe open leg fractures, reducing infection and helping bones heal without needing a second surgery.
- What could go wrong
- This is a small, early observational study with only 45 people, so results may not apply to everyone. The bone graft might not work as well as hoped, and infection or poor healing are still possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for OPEN PILON FRACTURES are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Missouri - Columbia
RECRUITINGColumbia, Missouri, 65201, United States