New bone graft could cut infection in severe leg breaks
NCT ID NCT07227493
First seen Nov 12, 2025 · Last updated Jun 20, 2026 · Updated 28 times
Summary
This study looks at a new bone graft material called Fibergraft Aeridyan Matrix for treating open pilon fractures, which are severe breaks in the lower leg that often get infected or don't heal well. Researchers will follow 45 adults who need bone grafting as part of their standard care, using extra CT scans at 6 and 12 months to check healing. The goal is to see if this material reduces infection and helps bones heal better than current methods.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Missouri - Columbia
RECRUITINGColumbia, Missouri, 65201, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Fibergraft Aeridyan Matrix (bioactive glass and collagen bone graft substitute)
What this could lead to
If successful, this could provide a better way to treat severe open leg fractures, reducing infection and helping bones heal without needing a second surgery.
What could go wrong
This is a small, early observational study with only 45 people, so results may not apply to everyone. The bone graft might not work as well as hoped, and infection or poor healing are still possible.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.