University Of Missouri-columbia

This study tests a simplified, accelerated HIV care model called ACCELERATE. It combines rapid telehealth appointments, a pre-approved HIV medication, and a free 30-day starter supply to help people with HIV who have fallen out of care get back on track. The goal is to see if thi…

This study tests whether giving a standard amount of IV fluid (Lactated Ringer's solution) before anesthesia can prevent low blood pressure during cystoscopy. About 100 adults having elective cystoscopy will receive the fluid bolus, and researchers will track how many experience …

This study planned to test whether a 14-day ketogenic diet before heart bypass surgery could reduce confusion and memory loss in adults aged 60 and older. The diet was thought to lower brain inflammation and improve brain cell health. However, the study was withdrawn before any p…

This study tests whether giving a mix of three drugs (methadone, dexmedetomidine, and ketamine) during complex spine surgery can lower pain and reduce the need for opioid painkillers afterward. About 248 adults aged 18-79 having surgery on three or more spine levels will take par…

This study tests whether remote monitoring through a secure app can safely replace in-person follow-up visits after wrist fracture surgery. Researchers will compare recovery, satisfaction, and complication rates between 160 adults who use virtual check-ins and those who attend st…

This study tests whether virtual reality (VR) meditation can improve sleep and reduce anxiety in people with chronic pain and insomnia. About 30 adults with both conditions for at least 6 months will use VR meditation and track their sleep, pain, and mood. The goal is to see if t…

This study tests an intensive group physical therapy program for children aged 7-17 with cerebral palsy who can walk. The program focuses on improving muscle strength, walking speed, and daily activities like climbing stairs. Researchers will measure changes in strength, balance,…

This registry follows patients who receive donor cartilage or meniscus transplants for joint defects in the knee, hip, ankle, or shoulder. Researchers are collecting long-term data on pain, function, and whether the grafts need revision or fail over time. The goal is to understan…

This study looks at how high-protein drinks affect certain blood cells (monocytes and platelets) that may play a role in heart disease. Ten healthy adults will drink either a low-protein, high-protein, or leucine-added meal, and researchers will check their blood for changes in c…

This study looks at how fat tissue takes up sugar in people with obesity, comparing those with normal blood sugar to those with insulin resistance. Researchers will use labeled sugar infusions and PET scans to measure sugar uptake in fat and muscle. The goal is to understand why …

This study looks at why sleep apnea raises the risk of diabetes. Overweight adults with and without sleep apnea will have their blood sugar control measured. Some will receive CPAP, some will get extra oxygen at night, and others will get a sham treatment. The goal is to find out…

This study looks at whether wearable technology, like the Oura Ring, can help measure stress and burnout in nurses. Fifty nurses from intensive care and surgical units will wear the rings and fill out surveys for 10 weeks. The goal is to see if workload and stress levels are link…

This study is testing whether a Mediterranean-style low-carb diet that reduces calories can lower insulin and testosterone levels in overweight or obese women with insulin resistance. Eight premenopausal women aged 21-45 will follow the diet to lose about 5% of their body weight.…

This early study tests whether sirolimus, an FDA-approved drug, can improve blood flow to the brain in healthy adults with a genetic risk for Alzheimer's disease. Researchers will use MRI scans to measure changes after 4 weeks of daily low-dose sirolimus. The study also explores …

This study aimed to see if a mix of telehealth and in-person physical therapy helps children with moderate to severe disability improve their home function better than in-person therapy alone. It planned to include children aged 2-17 and measure changes in daily living skills and…

This study looks at how different patterns of cannabis use (like how often, how long, and what type) affect anesthesia needs and inflammation in people having lumbar spine surgery. Researchers will measure the amount of anesthesia and pain medication needed during surgery, as wel…

This study looks at how eating a diet rich in pulses—like beans, lentils, and peas—affects the gut microbiome, feelings of fullness, and appetite hormones. Researchers are enrolling 44 overweight or obese adults who will follow a high-pulse diet for four weeks. The goal is to see…

This study looks at how insulin in the brain changes blood flow and nerve signals in healthy adults aged 18-45. Researchers will measure blood flow in the brain and legs, as well as nerve activity. The goal is to understand basic body functions, not to treat any disease.