Fat Tissue's role in blood sugar: new study targets obesity mystery

NCT ID NCT02994459

Ongoing Knowledge-focused Sponsor: University of Missouri-Columbia Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how fat tissue takes up sugar in people with obesity, comparing those with normal blood sugar to those with insulin resistance. Researchers will use labeled sugar infusions and PET scans to measure sugar uptake in fat and muscle. The goal is to understand why some obese individuals stay metabolically healthy while others do not. A small weight-loss program is included for obese participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: diet-induced weight loss
What this could lead to: If successful, this study could clarify why some people with obesity maintain normal blood sugar, potentially guiding personalized treatments for metabolic health.
What could go wrong: This is an observational study with a small sample size (90 participants). It does not test a new drug or therapy, so direct patient benefits are not expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glucose metabolism disease obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLUCOSE METABOLISM DISORDERS

Contacts and locations

Locations

Washington University School of Medicine

St Louis, Missouri, 63110, United States

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