University Of Missouri-columbia

This study compares a new type of breathing device (biphasic cuirass ventilator) to standard non-invasive ventilation in 50 high-risk patients who are about to have their breathing tube removed. The goal is to see if the new device can reduce the number of patients who need to be…

This phase 1 trial tests whether sirolimus (rapamycin), an FDA-approved medication, can improve blood flow and energy use in the brains of women aged 45 to 65 who carry the ApoE4 gene — a gene that raises the risk of developing Alzheimer's disease. Participants are randomly assig…

This study tests a remote, 12-week program called PREP for teens with cerebral palsy and their caregivers. The program helps families set activity goals and overcome barriers at home, school, and in the community. Researchers will see if the program is practical and liked by fami…

This study looks at whether a type of talk therapy for insomnia (CBT-I) can also improve markers of metabolic syndrome, like blood sugar and insulin resistance. Twenty adults with insomnia and higher body weight will be randomly assigned to CBT-I or basic sleep tips for 5 weeks. …

This study looks at how beta-cells (which make insulin) respond to growth hormone in people with prediabetes. Researchers will measure insulin release in 10 adults with impaired fasting glucose or impaired glucose tolerance. The goal is to better understand what raises the risk o…

This early-phase study will test how insulin given as a nasal spray affects nerve activity and blood flow in the brain and legs. Researchers will compare 64 adults with obesity and insulin resistance to healthy-weight individuals. The goal is to understand how obesity changes the…

This early study tests whether a drug called gemtesa (used for overactive bladder) can improve blood vessel function in women aged 18 to 70. Researchers want to see if targeting beta3 receptors in blood vessels can help them relax and improve blood flow. The trial involves 60 hea…