University Of Missouri-columbia

This study tests a 'Drinking Dashboard' that gives young adults weekly personalized feedback on their alcohol use and blackout risks. Participants are 18–30 years old who binge drink and have had alcohol-induced memory loss in the past month. The goal is to see if this simple too…

This trial tests whether a smart sensor system, combined with health education delivered via tablet, can reduce disability and improve quality of life for older adults living in rural areas. Participants are 65 or older, have some difficulty with daily tasks, and live in a rural …

This study tests a program called 'Disfrutando' designed to help people with type 2 diabetes, especially those in high-burden communities, better manage their condition. The program focuses on practical self-management skills and addressing social factors that make diabetes harde…

This study tested whether a dietary supplement called phosphatidylserine can improve blood flow in people with type 2 diabetes. 36 adults took either the supplement or a placebo for 4 weeks. Researchers measured blood flow in the leg and arm to see if the supplement helped blood …

This study tested whether amiloride, a drug that blocks sodium channels, can improve artery stiffness and blood vessel function in people who are overweight and insulin resistant. 137 men and women (pre- and postmenopausal) took either amiloride or a placebo daily for 6 months. T…

This study tested a new system called the Opioid Rapid Response System (ORRS) that uses a smartphone app to train and alert everyday people to respond to opioid overdoses with the life-saving drug naloxone. Over 700 adults from communities using the PulsePoint app took part. The …

This study looked at whether a 4-week behavioral sleep program could improve both sleep and thinking in 62 older adults with chronic insomnia. Participants learned sleep habits, relaxation, and adjusted their bedtimes. The researchers measured sleep changes and daily thinking per…

This study tested two different drugs used to reverse the effects of a muscle relaxant (rocuronium) after elective spine surgery. The goal was to see if one drug (sugammadex) causes less urinary retention (trouble urinating) than the standard combination (neostigmine/glycopyrrola…

This study tested whether a remote cognitive strategy training program (CO-OP) is feasible for people with Post-COVID syndrome who have memory or thinking problems. 65 participants learned a step-by-step problem-solving method (Goal-Plan-Do-Check) to improve daily activities. The…

This study tested a metacognitive strategy training approach called CO-OP to help people who had a stroke improve their ability to perform daily activities and reduce motor impairment. Seventy-two adults who had a stroke within the past 9 months were randomly assigned to either t…

This study tested whether giving a single dose of pregabalin (Lyrica) before ureteroscopy—a surgery for kidney stones that often leaves a temporary stent in the ureter—can reduce pain and the need for opioid painkillers afterward. 118 adults were randomly assigned to receive eith…

This study tested whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce pain in women with fibromyalgia. 131 women with both conditions received either CBT-I or sleep hygiene education. Researchers measured sleep quality, pain sensitivity, and bra…

This study investigates whether sex and obesity influence how blood vessels respond to low oxygen levels, a key factor in sleep apnea. Researchers will compare healthy-weight and obese men and women to see if differences in vessel constriction and dilation help explain why women …

This study tested a special belt that uses electrical currents to measure lung function in 30 obese patients during laparoscopic surgery. The goal was to see if the belt could set the breathing machine pressure better than standard methods. The results may help improve breathing …

This study worked with 42 Cherokee citizens to design a program that strengthens community connections and shares cultural knowledge. The goal was to see if this approach could help lower blood pressure and improve mental well-being. The project had two phases: first gathering he…

This study looked at how the drug Palynziq, which lowers phenylalanine levels in the blood, affects the brain and thinking abilities in adults with phenylketonuria (PKU). Six participants who were already taking Palynziq underwent brain scans and cognitive tests to measure change…

This study looked at how a night of restricted sleep changes blood flow to the brain in healthy adults. Sixteen men and women had their brain blood flow measured after normal sleep and after limited sleep. Researchers wanted to see if the effect was stronger in men. The goal was …

This completed early-phase study at the University of Missouri looked at how low oxygen (hypoxia) changes blood flow in 31 healthy adults. Researchers gave participants either a beta-blocker (propranolol) or a placebo to see if the nervous system plays a role in sex-related diffe…