New drug combo aims to cut opioid use after spine surgery
NCT ID NCT07365800
First seen Jan 28, 2026 · Last updated Jun 22, 2026 · Updated 23 times
Summary
This study tests whether giving a mix of methadone, dexmedetomidine, and ketamine during complex spine surgery can reduce pain and the need for opioid painkillers afterward. About 248 adults having surgery on three or more spine levels will take part. The goal is to see if this combination offers better pain control with fewer opioid-related risks.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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University Hospital
Columbia, Missouri, 65212, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
methadone, dexmedetomidine, and ketamine combination
What this could lead to
If it works, this could offer a way to manage pain after spine surgery with fewer opioids, lowering the risk of addiction and side effects.
What could go wrong
This is a Phase 4 study, so the drugs are already approved, but the combination may not work better than standard care, and each drug has its own risks like sedation or heart issues.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.