Do men and Women's blood vessels react differently to low oxygen? a study investigates
NCT ID NCT05219799
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This study examines whether sex and obesity influence how blood vessels widen in response to low oxygen levels. Researchers will infuse several drugs into the forearm artery of 72 healthy volunteers to block or stimulate specific nerve signals, measuring changes in blood flow. The goal is to uncover key mechanisms behind sex differences in vascular function, which may inform future treatments for obesity-related health issues.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Propranolol, isoproterenol, phentolamine, and norepinephrine infused into the forearm artery
- What this could lead to
- If successful, this could help explain why men and women differ in blood vessel responses during low oxygen, potentially guiding future treatments for conditions like obesity-related vascular problems.
- What could go wrong
- This is an early-phase, small study (72 participants) focused on basic mechanisms, not a treatment trial. Results may not translate to real-world health outcomes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Missouri
RECRUITINGColumbia, Missouri, 65211, United States
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