INSULIN RESISTANCE

This study looked at whether a ketogenic, low-calorie diet can reduce harmful gut-related toxins in the blood and improve insulin resistance in prediabetic obese adults aged 18-40. Ninety participants were split into three groups: a keto low-calorie diet, a normal low-calorie die…

This study tested whether inositol, a natural supplement, can lower high testosterone levels in women with Polycystic Ovary Syndrome (PCOS). 154 women with PCOS took different doses of inositol to see which dose works best. The goal is to improve hormone balance and reduce sympto…

This study tested whether eating only during a 10-hour window each day (and fasting for 14 hours) while choosing foods that are less calorie-dense can improve insulin resistance and reduce body weight. Forty older adults with obesity and insulin resistance participated. Researche…

This study tested a program that used financial rewards and text messages to encourage physical activity in 75 teens and young adults (ages 13-22) with prediabetes or type 2 diabetes. Participants wore a Fitbit to track their steps and moderate-to-vigorous activity. The goal was …

This study looked at 192 women with PCOS to see which treatment works best for improving insulin resistance, weight, and menstrual cycles. Participants were randomly assigned to take metformin, inositol, follow a calorie-restricted diet, or combine all three for 12 weeks. The goa…

This study tested whether amiloride, a drug that blocks a sodium channel (ENaC), can improve artery function and reduce stiffness in overweight adults with insulin resistance. The trial included 137 pre- and postmenopausal women and age-matched men. Researchers measured arterial …

This study looked at whether eating honey every day can improve insulin resistance in obese women who are at risk for diabetes. Twenty women took part, and researchers measured things like blood sugar, insulin, and body fat. The goal was to see if honey could be a simple way to h…

This study looked at whether taking a natural plant supplement called phytosterol can help people with nonalcoholic fatty liver disease (NAFLD). 27 adults took the supplement for 3 months. Researchers measured changes in liver enzymes, cholesterol, insulin, and inflammation. The …

This study looked at how well adults with obesity or complicated overweight can stick with different very-low-calorie ketogenic diets. Participants chose one of four diet types, ranging from natural foods to meal replacements, and followed a 26-week program. The goal was to see w…

This study looked at whether taking a Cistanche deserticola extract along with aerobic exercise for 18 weeks can improve body composition, insulin resistance, and inflammation in men with central obesity (excess belly fat). 125 Chinese men aged 50-55 with a large waist and high B…

This study looked at whether drinking a carbohydrate-rich beverage two hours before heart surgery could reduce insulin resistance—a condition where the body struggles to use insulin, leading to high blood sugar and slower recovery. Fifty adults undergoing cardiac surgery with a h…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 adolescents aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. The goal was to…

This study looked at whether taking fish oil supplements while exercising can lower inflammation linked to obesity. Overweight adults with high triglycerides and prediabetes took fish oil and followed an exercise program for several weeks. Researchers measured changes in blood ma…

This study tested whether colchicine, a common anti-inflammatory medicine, could improve metabolism in people with obesity who have high inflammation and high insulin levels but not yet high blood sugar. About 152 adults and teens took colchicine or a placebo daily for 12 weeks. …

This study tested whether taking a mangosteen supplement (500 mg twice daily) alongside the common diabetes drugs sitagliptin and metformin could improve blood sugar control in people newly diagnosed with type 2 diabetes. A total of 47 adults completed the 12-week trial. Research…

This study tested whether the drug metformin helps improve fertility-related hormones and reduce inflammation in women with Polycystic Ovary Syndrome (PCOS). 110 women with PCOS took metformin for 8 weeks and provided blood samples and symptom reports at the start and end. The go…

This study looked at whether eating sorghum rice instead of white rice for one week could improve health markers in people with prediabetes. Twenty-six police officers with prediabetes were split into two groups: one ate sorghum rice, the other white rice. Researchers measured ch…

This study looked at whether a 12-week program combining strength and endurance exercises could help women with insulin resistance improve how their bodies use insulin and keep blood vessels healthy. About 49 women aged 25-45 with insulin resistance but not diabetes took part. Th…

This study looked at whether antioxidants in orange juice can help the body respond better to insulin. Overweight but otherwise healthy women drank either orange juice or a similar-tasting drink without the antioxidants every day for three months. Researchers measured insulin sen…

This study tested whether a daily chromium picolinate supplement could reduce the severity of acanthosis nigricans (dark, thick skin patches) and improve insulin resistance in 90 adolescents aged 12-18. Participants took either chromium or a placebo for 24 weeks. Researchers meas…

This small study looked at whether sourdough bread made with a longer fermentation time (which increases natural acids) could help control blood sugar spikes in adults with prediabetes. Five participants ate different sourdough breads and had their blood sugar measured afterward.…

This study measured levels of a protein called betatrophin in 90 adolescent girls with and without PCOS. Researchers wanted to see if betatrophin is linked to insulin resistance and body weight in PCOS. The goal was to better understand the metabolic issues behind PCOS, not to te…

This study examined 158 adults aged 55-69 to see if certain immune system markers are linked to insulin resistance, a condition that can lead to diabetes. Researchers measured various immune cells and other blood markers to find patterns that might help identify people at risk. T…

This study tested whether a blood protein called PTX3 can predict how much weight people lose and how their metabolism improves after gastric bypass surgery. Researchers followed 23 adults with obesity for 6 months after surgery. The goal was to see if PTX3 levels before surgery …

This study looked at 106 teenage girls (70 with PCOS and 36 healthy) to see if vitamin D levels are linked to belly fat and metabolic problems like insulin resistance. Researchers measured blood vitamin D, sugar, insulin, cholesterol, and belly fat using ultrasound. The goal was …

This study tested a new computer method to check insulin resistance in real time for very sick patients in the ICU. Researchers used continuous glucose monitors to track blood sugar changes and built an algorithm to measure insulin resistance without invasive tests. The study inc…

This study looked at how trans fats from dairy products and from industrial sources affect insulin resistance in 66 obese women. The goal was to see if these different types of trans fats have different effects on the body's ability to use insulin. Participants underwent tests to…

This study looked at how two different but equally healthy diet plans affect insulin levels and other markers of metabolic health in adults who are overweight or at risk for insulin resistance. Researchers measured changes in blood sugar control, cholesterol, and metabolism over …

This study looked at how different insulin levels impact blood sugar in 18 adults with overweight, insulin resistance, and non-alcoholic fatty liver disease (NAFLD). Participants underwent two procedures where insulin was either kept steady or slowly reduced, and researchers meas…

This study looked at how not getting enough sleep changes two key hormones, cortisol and testosterone, and whether these changes lead to insulin resistance, a major cause of type 2 diabetes. Researchers studied 40 healthy men aged 22-45 to measure these effects, along with mood, …

This study aimed to uncover the genetic and lifestyle factors that cause pre-diabetes to turn into type 2 diabetes. Over 1,700 healthy adults aged 18 to 55 underwent detailed tests of how their bodies handle sugar and store fat. Researchers hope these findings will lead to better…

This study looked at how physical fitness helps children ages 8 to 17 process a high-fat meal. Researchers measured fitness with a treadmill test and checked blood markers after the meal. The goal was to see if fitter kids have better fat metabolism and lower insulin resistance.

This study looked at how drinking beverages with different sweeteners—low-calorie sweetener (sucralose), refined sugar (sucrose), or natural fruit juice—affects blood sugar levels and gut health in healthy adults. 42 people took part, drinking one type of sweetened drink daily fo…

This study aimed to find the smallest amount of fatty acids that can temporarily cause mild insulin resistance in healthy volunteers. Nine participants received a fat infusion to see how it affects their body's ability to use insulin. The results will help design future studies o…

This study looked at 48 non-diabetic adults with obstructive sleep apnea to see if those with low oxygen levels (hypoxia) have greater insulin resistance in the liver and fat tissue. Researchers measured how the body makes new fats and stored fat in the liver using special scans …

This study looked at whether a short therapy program for depression could help prevent type 2 diabetes in teenage girls at high risk. Researchers tested a cognitive-behavioral therapy group against a health education group in 147 girls aged 12-17 with depressive symptoms and a fa…

This study looked at how one session of exercise affects the brain's ability to respond to insulin in adults aged 40 to 80 who are overweight or obese. Researchers measured brain blood flow and thinking skills before and after exercise. The goal is to understand how exercise migh…

This study examined 549 older adults (65+) to see if metabolic syndrome is connected to vitamin D levels, even in those without vitamin D deficiency. Researchers used surveys and blood tests to gather data. The goal was to better understand these relationships, not to test a trea…

This study looked at how certain immune cells, called eosinophils, interact with fat tissue in people with obesity and insulin resistance. Four participants provided fat biopsies and blood samples to measure immune cell levels and markers of inflammation. The goal was to better u…

This study looked at whether a drug called diazoxide, which lowers high insulin levels, can change how the liver handles fat and sugar in people with overweight or obesity who have or are at risk for non-alcoholic fatty liver disease (NAFLD). Twenty-four adults took either a low …

This study looked at how resistance exercise (like weight lifting) improves insulin sensitivity and muscle health in people with insulin resistance and obesity. Researchers measured changes in muscle strength, insulin response, and body composition in 58 adults aged 50-75. The go…

This study looked at how different exercise intensities change levels of ghrelin, a hormone that controls hunger, in 40 adults with obesity and prediabetes. Researchers measured ghrelin in the blood and checked appetite, insulin sensitivity, and blood vessel function. The goal wa…

This study looked at whether sleeping longer (over 7 hours a night) can improve how the body processes sugar in people with obesity and early signs of insulin resistance. 31 participants were split into two groups: one aimed to sleep more, the other kept their usual sleep habits.…

This study looked at whether the brain's central clock (the suprachiasmatic nucleus) works differently in people with insulin resistance or type 2 diabetes. Researchers used advanced MRI scans to measure brain activity in response to light in 28 obese adults. The goal was to bett…

This study looked at 146 healthy women of African, African-American, and white backgrounds to see if risk factors for diabetes and heart disease differ by race. Participants completed several visits including blood tests, glucose tolerance tests, body fat measurements, and meal t…

This study looked at 150 adults to see if two simple, low-cost blood tests (TGI and TGI-BMI) can accurately detect insulin resistance, a key risk factor for type 2 diabetes and heart disease. Researchers compared these tests to the standard but more complex HOMA-IR test. They fou…

This study tested whether a personalized lifestyle program could help people with obesity and related conditions like prediabetes or high blood pressure improve their insulin resistance. Forty adults received either nutrition or exercise counseling first, and if they didn't impro…

This study tested whether metformin, a common diabetes drug, can slow aging in healthy adults aged 40 to 75. Researchers gave metformin or a placebo to 101 participants for 12 weeks to see how it affected insulin sensitivity, blood sugar control, and mitochondrial function. The g…

This study looked at whether 3 weeks of alternate-day fasting helps the heart use a special fuel called ketones more efficiently compared to a typical Western diet. Sixteen adults aged 55-70 with obesity and insulin resistance underwent PET scans and lab tests after each diet per…

This study looked at whether a protein called IRAP, found in the blood, can be used as a marker for insulin sensitivity (how well the body uses insulin). Researchers measured IRAP levels in 21 healthy adults during a special test called a hyperinsulinemic-euglycemic clamp, which …

This study looked at whether certain immune cells can make the body less responsive to insulin, a hormone that controls blood sugar. Researchers took blood samples from 30 adults and tested how their immune cells affected liver cells in a lab. The goal was to better understand ho…