Sugar showdown: natural vs. refined vs. fake sweeteners – which spikes blood sugar?

NCT ID NCT07194772

First seen Nov 01, 2025 · Last updated Jun 05, 2026 · Updated 30 times

Summary

This study looked at how drinking beverages with different sweeteners—low-calorie sucralose, refined sugar, or natural fruit juice—affects blood sugar control and gut health in healthy adults. Over three weeks, 42 participants drank one type of sweetened drink daily. Researchers measured blood sugar and insulin responses, as well as changes in gut bacteria and inflammation markers. The goal was to understand real-world effects of common sweeteners on metabolism.

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Contacts and locations

Locations

  • Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa

    Ottawa, Ontario, K1S 5S9, Canada

Conditions

The condition(s) this trial relates to.

glucose intolerance Insulin Resistance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.